tPA is a thrombolytic agent widely used in clinical settings. While double gene co-integration into organisms can produce synergistic effects and improved expression levels of the target gene, there are few reports detailing the co-integration of the and genes and an increased expression level of tPA. In order to study this, we obtained monoclonal goat mammary epithelial cell lines with / double gene integration and we analyzed the tPA expression level of single and double gene integration cells.
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