A high-performance non-enzymatic electrochemical hydrazine sensor based on NiCoS porous sphere.

A non-enzymatic electrochemical sensor-NiCoS/GCE was constructed for sensitive and selective detection of hydrazine (NH), which was designed based on porous nanostructure and synthesized through a facile hydrothermal method. The nanocomposite has been characterized using a series of characterizations such as X-ray powder diffraction (XRD), scanning electron microscopic (SEM), transmission electron microscopy (TEM), showing the porous NiCoS sphere was made of interconnected nanoparticles with porous structure. Electrochemical measurements revealed that the porous NiCoS sphere based sensor exhibited an excellent voltammetric response towards the NH oxidation with a wide linear range of 1.

State-Based Liver Distribution: Broad Sharing With Less Harm to Vulnerable and Underserved Communities Compared With Concentric Circles.

Allocation of livers for transplantation faces regulatory pressure to move toward broader sharing. A current proposal supported by the United Network for Organ Sharing Board of Directors relies on concentric circles, but its effect on socioeconomic inequities in access to transplant services is poorly understood. In this article, we offer a proposal that uses the state of donation as a unit of distribution, given that the state is a recognized unit of legal jurisdiction and socioeconomic health in many contexts.

Electrostatic assembly of gold nanoparticles on black phosphorus nanosheets for electrochemical aptasensing of patulin.

An aptamer based impedimetric assay for the mycotoxin patulin (PAT) is described. A glassy carbon electrode (GCE) was modified with black phosphorus nanosheets (BP NSs) and modified with PAT aptamer by electrostatic attraction. Detection is based on the variations of electron transfer resistance at the modified electrode surface.

An experimental study to quantify road greenbelts and their association with PM concentration along city main roads in Nanjing, China.

Air pollution is an important environmental and health concern all over the world and PM is one of the most important constituents of air pollution. In urban area with high population density, vehicles contribute a big portion of PM. The effect of vegetations along road, i.

Beta cell secretion of miR-375 to HDL is inversely associated with insulin secretion.

Extracellular microRNAs (miRNAs) are a new class of biomarkers for cellular phenotypes and disease, and are bioactive signals within intercellular communication networks. Previously, we reported that miRNAs are secreted from macrophage to high-density lipoproteins (HDL) and delivered to recipient cells to regulate gene expression. Despite the potential importance of HDL-miRNAs, regulation of HDL-miRNA export from cells has not been fully studied.

[Clinical characteristics of hepatic flare and efficacy of antiviral therapy in pregnant women with chronic hepatitis B virus infection].

To analyze the clinical characteristics of hepatic flare and evaluate efficacy of antiviral treatment in pregnant women with chronic HBV infection. A single-center, open-label, prospective study was conducted, and pregnant women with chronic HBV infection were enrolled. Liver function, HBV serum markers and HBV DNA of pregnant women with chronic HBV infection were reviewed during every 4 to 12 weeks of gestation period.

[Considerations of using oral nucleos(t)ide analogues to interrupt mother-to-child transmission in HBV carrier pregnant woman with high viral load].

The main transmission route of chronic hepatitis B virus infection is mother-to-child transmission of hepatitis B virus and the main cause of combined immune prophylaxis failure in neonates at the end of pregnancy is high viral load. Moreover, oral administration of nucleos(t)ide analogues (NAs) during the second and third trimesters of pregnancy can significantly reduce or even completely block mother-to-child transmission of HBV. This article focuses on the necessity and feasibility of oral NAs antiviral therapy for HBV carrier pregnant woman with high viral load, and the issues commences at the time of medication and viral load thresholds.

A case report of a giant mature teratoma of the thyroid gland in a young girl.

Rationale: Teratomas are extremely rare in the thyroid gland. A cervical teratoma presenting as a cystic or mixed thyroid lesion can be easily confused with a thyroglossal duct cyst. It is difficult for pediatricians to differentiate between these 2 types of lesions.

Ectopic expression of the AaFUL1 gene identified in Anthurium andraeanum affected floral organ development and seed fertility in tobacco.

Anthurium andraeanum is a high-grade potted flower that enjoys global popularity. Its floral organs have been substantially modified, and its ornamental value is based on its petaloid bracts. MADS-box gene products are important transcription factors that control plant development.

Hydrophilic Nanocomposite Functionalized by Carrageenan for the Specific Enrichment of Glycopeptides.

A hydrophilic nanocomposite was synthesized by an easy route to improve glycopeptides enrichment efficiency. This new composite, prepared with a method based on electrostatic interaction, was demonstrated to be efficient for immobilization of carrageenan on graphene oxide/poly(ethylenimine) support (denoted as GO-PEI-Carr). Carrageenan, which has a large number of hydroxyl groups and is fully negatively charged, is a new modified phase of hydrophilic materials in glycoproteomics.

Effects of Nitrogen Dioxide on Biochemical Responses in 41 Garden Plants.

Nitrogen dioxide (NO₂) at a high concentration is among the most common and harmful air pollutants. The present study aimed to explore the physiological responses of plants exposed to NO₂. A total of 41 plants were classified into 13 functional groups according to the Angiosperm Phylogeny Group classification system.

Dual inhibition of endothelial miR-92a-3p and miR-489-3p reduces renal injury-associated atherosclerosis.

Background And Aims: Cardiovascular disease (CVD) is the leading cause of death in chronic kidney disease (CKD) patients, however, the underlying mechanisms that link CKD and CVD are not fully understood and limited treatment options exist in this high-risk population. microRNAs (miRNA) are critical regulators of gene expression for many biological processes in atherosclerosis, including endothelial dysfunction and inflammation. We hypothesized that renal injury-induced endothelial miRNAs promote atherosclerosis.

WITHDRAWN: Effects of cancer-associated point mutations on the structure, function, and stability of succinate dehydrogenase A.

This article has been withdrawn by the authors. Some of the SDHA enzyme activity data were flawed and were not performed and analyzed correctly. The withdrawing authors are in the process of correcting the data and re-evaluating them for resubmission.

Whole Exome Sequencing Identifies a Novel Pathogenic RET Variant in Hirschsprung Disease.

Hirschsprung disease is a birth defect characterized by complete absence of neuronal ganglion cells from a portion of the intestinal tract. To uncover genetic variants contributing to HSCR, we performed whole exome sequencing on seven members of an HSCR family. With the minor allele frequency (MAF) calculated by gnomAD, we finally filtered a total of 1,059 rare variants in this family (MAF < 0.

A Silicon-tipped Fiber-optic Sensing Platform with High Resolution and Fast Response.

In this article, we introduce an innovative and practically promising fiber-optic sensing platform (FOSP) that we proposed and demonstrated recently. This FOSP relies on a silicon Fabry-Perot interferometer (FPI) attached to the fiber end, referred to as Si-FOSP in this work. The Si-FOSP generates an interferogram determined by the optical path length (OPL) of the silicon cavity.

Wavelength tuning and power enhancement of an intracavity Nd:GdVO-BaWO Raman laser using an etalon.

We report the wavelength tuning, linewidth narrowing and power enhancement of a continuous-wave intracavity Raman laser by incorporating solid etalons in the high-Q fundamental resonator. With a-cut Nd:GdVO and a-cut BaWO serving as the laser and Raman crystals respectively, tilting of a 50 μm-thick etalon in the high-Q fundamental cavity enabled the fundamental to be tuned from 1061.00 nm to 1065.

Human PAH is characterized by a pattern of lipid-related insulin resistance.

Background: Pulmonary arterial hypertension (PAH) is a deadly disease of the small pulmonary vasculature with an increased prevalence of insulin resistance (IR). Insulin regulates both glucose and lipid homeostasis. We sought to quantify glucose- and lipid-related IR in human PAH, testing the hypothesis that lipoprotein indices are more sensitive indices of IR in PAH.

Bmo-miR-79 downregulates the expression of BmEm4 in the silkworm, Bombyx mori.

MicroRNA is an important regulation factor in insect development and metamorphosis. It has been reported that E(spl)m4 is a miRNA-targeted gene, as well as the target of the Notch signaling pathway in Drosophila. The expression of E(spl)m4 can be regulated by microRNA and further affect the neural development of Drosophila.

beRBP: binding estimation for human RNA-binding proteins.

Identifying binding targets of RNA-binding proteins (RBPs) can greatly facilitate our understanding of their functional mechanisms. Most computational methods employ machine learning to train classifiers on either RBP-specific targets or pooled RBP-RNA interactions. The former strategy is more powerful, but it only applies to a few RBPs with a large number of known targets; conversely, the latter strategy sacrifices prediction accuracy for a wider application, since specific interaction features are inevitably obscured through pooling heterogeneous datasets.

A Stellar Imaging Error Correction Method Based on an Ellipsoid Model: Taking Ziyuan 3-02 Satellite Data Analysis as an Example.

Stellar point image coordinates are one of the important observations needed for high-precision space attitude measurement with a star sensor. High-coupling imaging errors occur under dynamic imaging conditions. Using the results of preliminary star point extraction from star sensor imaging data combined with a superimposed time series, we analyze the relative motion and trajectory based on the star point image, establish an image error ellipsoid fitting model based on the elliptical orbit of a satellite platform, and achieve geometric error correction of a star sensors' image star point using multi-parameter screening of the ambiguous solutions of intersection of the elliptic equations.

A Pilot Study on Parameter Setting of VisiTag™ Module during Pulmonary Vein Isolation.

Objectives: To identify optimal predefined criteria (OPC) for filters of the VisiTag™ module in the CARTO 3 system during pulmonary vein isolation (PVI).

Methods: Thirty patients with atrial fibrillation (AF) who experienced PVI first were enrolled. PVI was accomplished by using a Thermocool SmartTouch catheter.

Patterns of olfactory dysfunction in chronic rhinosinusitis identified by hierarchical cluster analysis and machine learning algorithms.

Background: Olfactory dysfunction is a common symptom of chronic rhinosinusitis (CRS). We previously identified several cytokines potentially linked to smell loss, potentially supporting an inflammatory etiology for CRS-associated olfactory dysfunction. In the current study we sought to validate patterns of olfactory dysfunction in CRS using hierarchical cluster analysis, machine learning algorithms, and multivariate regression.

Cancer-specific expression quantitative loci are affected by expression dysregulation.

Expression quantitative trait loci (eQTLs) have been touted as the missing piece that can bridge the gap between genetic variants and phenotypes. Over the past decade, we have witnessed a sharp rise of effort in the identification and application of eQTLs. The successful application of eQTLs relies heavily on their reproducibility.

Chronic rhinosinusitis in elderly patients is associated with an exaggerated neutrophilic proinflammatory response to pathogenic bacteria.

Background: Potential effects of aging on chronic rhinosinusitis (CRS) pathophysiology have not been well defined but might have important ramifications given a rapidly aging US and world population.

Objective: The goal of the current study was to determine whether advanced age is associated with specific inflammatory CRS endotypes or immune signatures.

Methods: Levels of 17 mucus cytokines and inflammatory mediators were measured in 147 patients with CRS.

Preparation of Ag@zeolitic imidazolate framework-67 at room temperature for electrochemical sensing of hydrogen peroxide.

In this work, a novel non-enzymatic hydrogen peroxide sensor, Ag@zeolitic imidazolate framework-67 (Ag@ZIF-67)/glassy carbon electrode (GCE), was fabricated by a simple method at room temperature. The morphology and structure of Ag@ZIF-67 were investigated by scanning electron microscopy, transmission electron microscopy, energy dispersive spectroscopy, Fourier transform infrared spectroscopy, powder X-ray diffraction, atomic absorption spectrophotometry, and N2 absorption isotherms, which indicated that core-shell Ag@ZIF-67 was successfully synthesized with a porous rhombic dodecahedron structure. Electrochemical investigations demonstrated that the Ag@ZIF-67/GCE had strong electrocatalytic activity towards hydrogen peroxide reduction with a low detection limit of 1.