3D bioprinting of prefabricated artificial skin with multicomponent hydrogel for skin and hair follicle regeneration.

The timely management of large-scale wounds and the regeneration of skin appendages constitute major clinical issues. The production of high-precision and customizable artificial skin via 3D bioprinting offers a feasible means to surmount the predicament, within which the selection of bioactive materials and seed cells is critical. This study is aimed at employing skin stem cells and multicomponent hydrogels to prefabricate artificial skin through 3D bioprinting, which enables the regeneration of skin and its appendages.

Mechanistic insights into the role of EGLN3 in pulmonary vascular remodeling and endothelial dysfunction.

Endothelial dysfunction is a pivotal initiating factor in vascular remodeling in pulmonary hypertension. EGLN3, a hypoxia response factor, plays a significant role in cell proliferation and angiogenesis, which are closely related to the pathophysiological conditions of pulmonary hypertension. This study investigates the potential involvement of EGLN3 in the injury response of pulmonary vascular endothelial cells and its contribution to the development of pulmonary arterial hypertension.

Caffeine ameliorates metabolic-associated steatohepatitis by rescuing hepatic Dusp9.

Caffeine (CAFF) is abundant in black coffee. As one of the most widely consumed beverages globally, coffee has been the focus of increasing clinical and basic research, particularly regarding its benefits in alleviating metabolic dysfunction-associated steatotic liver disease (MASLD). However, the therapeutic effects of CAFF on metabolic-associated steatohepatitis (MASH) and the underlying mechanisms remain unclear.

MMP8-mediated vascular remodeling in pulmonary hypertension.

Pulmonary arterial hypertension (PAH) is a vascular remodeling disease that impacts the cardiopulmonary system. Due to the currently limited understanding of vascular remodeling, a cure for PAH remains elusive. This study highlights the critical role of the STAT1 (signal transducer and activator of transcription 1)/MMP8 (matrix metallopeptidase 8)/DRP1 (dynamin-related protein 1) axis in vascular remodeling and the pathogenesis of pulmonary hypertension.

A hybrid recommendation algorithm based on user nearest neighbor model.

In the realm of e-commerce, personalized recommendations are a crucial component in enhancing user experience and optimizing sales efficiency. To address the inherent sparsity challenge prevalent in collaborative filtering algorithms within personalized recommendation systems, we propose a novel hybrid e-commerce recommendation algorithm based on the User-Nearest-Neighbor model. By integrating the user nearest neighbor model with other recommendation algorithms, this approach effectively mitigates data sparsity and facilitates a more nuanced understanding of the user-product relationship, consequently elevating recommendation quality and enhancing user experience.

PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids.

Background: PRM1201 is a traditional medicine with beneficial effects against colorectal cancer (CRC) metastasis. However, the underlying mechanism of this action remains to be determined.

Hypothesis: Remodeling microbiota and short-chain fatty acids (SCFAs) metabolism might be a potential mechanism to explain the anti-metastatic action of PRM1201, as this gut-microbiota dependent effect involves downregulation of histone deacetylation and EMT.

Simulation and calibration of radiation monitoring of nuclear power plant containment sump waste liquid.

Waste liquid stored in the containment sumps of nuclear power plants may contain a variety of radionuclides. Real-time monitoring of containment sump waste liquid can ensure that accidents, such as leakage of cooling water, can be avoided. This paper presents the design of a radioactive monitoring system for waste liquid in a containment sump.

A Fast-Charge Graphite Anode with a Li-Ion-Conductive, Electron/Solvent-Repelling Interface.

Graphite has been serving as the key anode material of rechargeable Li-ion batteries, yet is difficultly charged within a quarter hour while maintaining stable electrochemistry. In addition to a defective edge structure that prevents fast Li-ion entry, the high-rate performance of graphite could be hampered by co-intercalation and parasitic reduction of solvent molecules at anode/electrolyte interface. Conventional surface modification by pitch-derived carbon barely isolates the solvent and electrons, and usually lead to inadequate rate capability to meet practical fast-charge requirements.

exonic mutations induce abnormal biochemical activities and result in GCK-MODY.

Glucokinase-maturity-onset diabetes of the young (GCK-MODY; MODY2) is a rare genetic disorder caused by mutations in the glucokinase () gene. It is often under- or misdiagnosed in clinical practice, but correct diagnosis can be facilitated by genetic testing. In this study, we examined the genes of three patients diagnosed with GCK-MODY and tested their biochemical properties, such as protein stability and half-life, to explore the function of the mutant proteins and identify the pathogenic mechanism of GCK-MODY.

Effectiveness and safety analysis of Danggui Shaoyao Powder for the treatment of non-alcoholic fatty liver disease: study protocol for a randomized, double-blind, placebo-controlled clinical trial.

Background: The incidence of non-alcoholic fatty liver disease (NAFLD) has been on the rise in recent years, and there are no effective drugs to treat NAFLD; therefore, effective prevention and treatment of NAFLD have become a new challenge. Danggui Shaoyao Powder (DGSY) is a classic prescription commonly used in clinical practice and has been shown to reduce hepatic steatosis in patients with NAFLD. In addition, previous studies have shown that DGSY can alleviate hepatic steatosis and inflammation in NAFLD mice.

Clinical characteristics of a male child with non-classic lipoid congenital adrenal hyperplasia and literature review.

Background: Lipoid congenital adrenal hyperplasia (LCAH) is a rare and severe disorder that is caused by mutations in the steroidogenic acute regulatory protein (StAR). Non-classic LCAH is defined as late-onset glucocorticoid deficiency and even complete male external genitalia in 46,XY individuals. However, to date, few cases of non-classic LCAH have been reported.

meningitis after operative neurosurgery: A case report and review of literature.

Background: (), which causes central nervous system infections in adults, is very rare. It is also relatively difficult to culture mycoplasma and culturing requires special media, resulting in a high rate of clinical underdiagnosis. Therefore, clinicians often treat patients based on their own experience before obtaining pathogenic results and may ignore infections with atypical pathogens, thus delaying the diagnosis and treatment of patients and increasing the length of hospital stay and costs.

Incoherent coded aperture correlation holographic imaging with fast adaptive and noise-suppressed reconstruction.

Fast and noise-suppressed incoherent coded aperture correlation holographic imaging is proposed, which is utilized by employing an annular sparse coded phase mask together with adaptive phase-filter cross-correlation reconstruction method. Thus the proposed technique here is coined as adaptive interferenceless coded aperture correlation holography (AI-COACH). In AI-COACH, an annular sparse coded phase mask is first designed and generated by the Gerchberg-Saxton algorithm for suppressing background noise during reconstruction.

Characteristics and source apportionment of PM in Jiaxing, China.

Herein we investigated the morphology, chemical characteristics, and source apportionment of fine particulate matter (PM) samples collected from five sites in Jiaxing. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showed that soot aggregates and coal-fired fly ash were generally the most abundant components in the samples. All the samples were analyzed gravimetrically for mass concentrations and their various compositions were determined.

A meta-analysis: Evaluation of safety and efficacy of the epidermal growth factor receptor-tyrosine kinase inhibitor monotherapy versus platinum-based doublets chemotherapy in East Asia.

Objective: Several clinical trials have shown that advanced nonsmall cell lung cancer (NSCLC) patients can benefit from treatment with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) monotherapy than receiving platinum-based doublets chemotherapy in the first-line treatment of advanced NSCLC; the objective of this study was to evaluate whether patients could be treated with EGFR-TKI for advanced NSCLC in the first-line setting.

Patients And Methods: A literature search was conducted on the Cochrane Controlled Trials Register Databases, MEDLINE, EMBASE, Web of Science databases, and Chinese Biomedical Literature Database without exclusion of material published in any language. We performed a meta-analysis of five randomized studies that compared EGFR-TKI with platinum-based doublets chemotherapy for the patients of advanced NSCLC in the first-line setting.

Jejunojejunal intussusception after Roux-en-Y gastric bypass in a situs inversus totalis patient: A case report.

Introduction: Situs inversus totalis (SIT) is an uncommon clinical manifestation. Patients with SIT typically have malformation in the thorax and abdomen. The incidence of SIT ranges from 1/10,000 to 1/20,000 (Al-Jumaily and Hoche.

Delayed recovery from paralysis associated with plasma cholinesterase deficiency.

Introduction: This case was to describe a patient presented a 6 h length of apnea associated with low cholinesterase activity.

Case Description: A 32 years old female patient (body weight 50 kg, height 160 cm) was admitted to the hospital for laparoscopy combined with hysteroscopy exploration. The preoperative interrogation revealed no significant personal or family history of adverse reaction to anesthetics.

Anesthetic management for cesarean section in a patient with uncorrected double-outlet right ventricle.

Background: We describe the anesthetic management for cesarean section in a pregnant woman with uncorrected double-outlet right ventricle. The anesthetic method, treatment of complications and lessons are discussed.

Case Presentation: A 28-year-old woman visited our emergency room for progressive dyspnea and recurrent hemoptysis at 30 weeks' gestation.