Publications by authors named "Sheng Di Chen"
Background: Little is known about the impact of the COVID-19 pandemic on patients with Parkinson's disease (PD) at different stages of the pandemic. This study aims to assess the lives and disease status of PD patients during the zero-COVID policy period and after ending the zero-COVID policy.
Methods: This multicenter cross-sectional study included two online surveys among PD patients in China, from May 30 to June 30 in 2022 and from January 1 to February 28 in 2023, respectively.
Alzheimer's disease (AD) is the most common form of dementia and numerous studies reported a higher prevalence and incidence of AD among women. Although women have longer lifetime, longevity does not wholly explain the higher frequency and lifetime risk in women. It is important to understand sex differences in AD pathophysiology and pathogenesis, which could provide foundation for future clinical AD research.
View Article and Find Full Text PDFThe impact of coronavirus disease 2019 (COVID-19) pandemic on patients with neurodegenerative diseases and the specific neurological manifestations of COVID-19 have aroused great interest. However, there are still many issues of concern to be clarified. Therefore, we review the current literature on the complex relationship between COVID-19 and neurodegenerative diseases with an emphasis on Parkinson's disease (PD) and Alzheimer's disease (AD).
View Article and Find Full Text PDFBackground: Language deficits frequently occur during the prodromal stages of Alzheimer's disease (AD). However, the characteristics of linguistic impairment and its underlying mechanism(s) remain to be explored for the early diagnosis of AD.
Methods: The percentage of silence duration (PSD) of 324 subjects was analyzed, including patients with AD, amnestic mild cognitive impairment (aMCI), and normal controls (NC) recruited from the China multi-center cohort, and the diagnostic efficiency was replicated from the Pitt center cohort.
Background: Alzheimer's disease (AD) is the most common neurodegenerative disease and its pathogenesis is still unclear. There is dysbiosis of gut microbiota in AD patients. More importantly, dysbiosis of the gut microbiota has been observed not only in AD patients, but also in patients with mild cognitive impairment (MCI).
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- Genetic factors significantly influence the risk and progression of Parkinson's disease (PD), but little research has been done on how these factors affect progression specifically in Chinese patients.
- The study analyzed genetic variants (single nucleotide polymorphisms) in a cohort of Chinese PD patients, comparing results with a separate PPMI cohort, and assessed progression through various scales using advanced statistical models.
- Findings indicated that the rs1799836 variant is linked to cognitive decline and overall symptom progression in Chinese patients, while another variant, rs12456492, is associated with motor symptom progression, suggesting ethnic variations in these genetic influences on PD.
Background: Immune system dysfunction has been proven to be an important pathological event in Alzheimer's disease (AD). Mild cognitive impairment (MCI), as a transitional stage between normal cognitive function and AD, was an important research object for the screening of early diagnostic markers and therapeutic targets for AD. However, systematic assessment of peripheral immune system changes in MCI patients and consistent analysis with that in the CNS were still lacking.
View Article and Find Full Text PDFShort-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota through fermentation of dietary fiber. SCFAs participate a number of physiological and pathological processes in the human body, such as host metabolism, immune regulation, appetite regulation. Recent studies on gut-brain interaction have shown that SCFAs are important mediators of gut-brain interactions and are involved in the occurrence and development of many neurodegenerative diseases, including Alzheimer's disease.
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- Alzheimer's disease (AD) is primarily characterized by Tau pathology, and the study aims to explore the role of immune system dysfunction in its progression by identifying key immune hub genes correlated with different Braak stages.
- The researchers analyzed 60 samples from a dataset, employed various analytical tools to screen and validate immune core genes, and assessed the relationship between these genes and immune cell infiltration.
- They identified seven immune core genes, with KRAS and PIK3R1 showing a strong link to Tau and Aβ pathology, while also noting an increase in ImmuneScore and specific immune cell types corresponding to advancing Braak stages.
Background: Tai Chi has been shown to improve motor symptoms in Parkinson's disease (PD), but its long-term effects and the related mechanisms remain to be elucidated. In this study, we investigated the effects of long-term Tai Chi training on motor symptoms in PD and the underlying mechanisms.
Methods: Ninety-five early-stage PD patients were enrolled and randomly divided into Tai Chi (n = 32), brisk walking (n = 31) and no-exercise (n = 32) groups.
Monoamine oxidase-B (MAO-B) inhibitors are commonly used for the symptomatic treatment of Parkinson's disease (PD). MAO-B inhibitor monotherapy has been shown to be effective and safe for the treatment of early-stage PD, while MAO-B inhibitors as adjuvant drugs have been widely applied for the treatment of the advanced stages of the illness. MAO-B inhibitors can effectively improve patients' motor and non-motor symptoms, reduce "OFF" time, and may potentially prevent/delay disease progression.
View Article and Find Full Text PDFAltered Local Brain Amplitude of Fluctuations in Patients With Myotonic Dystrophy Type 1.
Front Aging Neurosci
December 2021
This study is aimed at investigating the characteristics of the spontaneous brain activity in patients with myotonic dystrophy type 1 (DM1). A total of 18 patients with DM1 and 18 healthy controls (HCs) were examined by resting-state functional MRI. Combined methods include amplitude of low-frequency fluctuations (ALFFs), the fractional amplitude of low-frequency fluctuations (fALFFs), and Wavelet transform-based ALFFs (Wavelet-ALFFs) with standardization, percent amplitude of fluctuation (PerAF) with/without standardization were applied to evaluate the spontaneous brain activity of patients with DM1.
View Article and Find Full Text PDFMRCG: A MRI Retrieval Framework With Convolutional and Graph Neural Networks for Secure and Private IoMT.
IEEE J Biomed Health Inform
February 2023
In the context of Industry 4.0, the medical industry is horizontally integrating the medical resources of the entire industry through the Internet of Things (IoT) and digital interconnection technologies. Speeding up the establishment of the public retrieval database of diagnosis-related historical data is a common call for the entire industry.
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- - The study surveyed 434 Chinese clinicians using a 21-item questionnaire to gather their opinions on diagnosing and managing functional movement disorders (FMD), revealing that over 80% view atypical movement, multiple somatizations, and emotional issues as crucial for diagnosis.
- - A significant portion of respondents (75%) indicated that standard neurological tests should be done to exclude organic causes, with many also believing factors like previous organic diagnosis and evidence of physical injury strongly influence non-FMD diagnoses.
- - Results showed a broad inclination among clinicians to refer patients to neuropsychiatrists (77.4%) and psychologists experienced with FMD, but highlighted gaps in guidelines and training, prompting calls for more research and clearer practice protocols in China
Article Synopsis
- * The analysis of 8,097 AD patients revealed that those with AD had a reduced risk for several cancers, with an overall hazard ratio of 0.822 for developing cancers.
- * While lung cancer and prostate/testicular cancers showed a lower risk in AD patients, an increased risk of lymphoma was noted, indicating a complex relationship between AD and cancer.
Article Synopsis
- Freezing of gait (FOG) is a common but poorly understood symptom in Parkinson's disease (PD), with prevalence rates reported between 5% to 85.9%.
- A systematic review and meta-analysis of 66 studies found that approximately 50.6% of 9072 PD patients experienced FOG, with higher rates in advanced stages of the disease.
- The findings suggest that FOG is often underestimated in clinical settings, highlighting the need for more precise assessment tools like specialized FOG questionnaires rather than general clinical questions.
Article Synopsis
- The heritability of familial late-onset Alzheimer's disease (FLOAD) is largely uncertain, with limited genetic profiles available; a study examined 90 FLOAD cases compared to 101 normal controls within the Chinese Han population.
- Targeted sequencing revealed lower mutation rates in the APP and PSEN genes, while the ε4 genetic risk factor was found to be more prevalent in FLOAD cases.
- Notably, novel pathogenic mutations, particularly frame-shift and nonsense mutations, were linked to FLOAD, impacting ACE protein levels without altering APP processing, supported by data from the Alzheimer's disease Neuroimaging Initiative (ADNI) database.
Article Synopsis
- The study investigates the differences in clinical features between male and female Parkinson's disease (PD) patients who carry the LRRK2 G2385R genetic variant.
- It analyzes data from 613 PD patients, focusing on cognitive impairment in males and autonomic dysfunction in females, showing that carriers of the variant have a lower risk of these conditions.
- Results indicate that females without the G2385R variant may have lower risks for daily living impairment and excessive daytime sleepiness but a higher risk for mood disorders compared to males.
In the past decade, numerous studies have demonstrated the close relationship between gut microbiota and the occurrence and development of Alzheimer's disease (AD). However, the specific mechanism is still unclear. Both the neuroinflammation and systemic inflammation serve as the key hubs to accelerate the process of AD by promoting pathology and damaging neuron.
View Article and Find Full Text PDFWe investigated the effects of botulinum toxin on gait in Parkinson's disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.
View Article and Find Full Text PDFParkinson's disease (PD) is a common neurodegenerative disease in the middle-aged and the elderly. Symptoms of autonomic dysfunctions are frequently seen in PD patients, severely affecting the quality of life. This review summarizes the epidemiology, clinical manifestations, and treatment options of autonomic dysfunctions.
View Article and Find Full Text PDFCSF1R-related leukoencephalopathy is a rare white-matter encephalopathy characterized by motor and neuropsychiatric symptoms due to colony-stimulating factor 1 receptor (CSF1R) gene mutation. Few studies have investigated the intrinsic brain alternations of patients with CSF1R-related leukoencephalopathy. We aim to evaluate the structural and functional changes in those patients.
View Article and Find Full Text PDFBackground: Paroxysmal kinesigenic dyskinesia is a spectrum of involuntary dyskinetic disorders with high clinical and genetic heterogeneity. Mutations in proline-rich transmembrane protein 2 have been identified as the major pathogenic factor.
Objectives: We analyzed 600 paroxysmal kinesigenic dyskinesia patients nationwide who were identified by the China Paroxysmal Dyskinesia Collaborative Group to summarize the clinical phenotypes and genetic features of paroxysmal kinesigenic dyskinesia in China and to provide new thoughts on diagnosis and therapy.