Mortality-related risk factors of carbapenem-resistant Enterobacteriaceae infection with focus on antimicrobial regimens optimization: a real-world retrospective study in China.

Objectives: To determine the mortality-related risk factors for carbapenem-resistant Enterobacteriaceae (CRE) infection in hospitalized patients and to compare the clinical efficacy of different antimicrobial regimen.

Methods: Data were retrospectively collected from a 3,500-bed regional medical center between January 2021 and June 2022. Mortality-related risk factors were analyzed by the Cox proportional regression model for multivariate analysis.

Integrated Network Pharmacology and Transcriptomics Analysis to Elucidate the Mechanism of Huoxue Tongluo Qiwei Decoction in the Treatment of Erectile Dysfunction in Spontaneously Hypertensive Rats through Angii-Activated Pkcε Pathway.

Background And Aim: As a classical formula to invigorate blood circulation, Huoxue Tongluo Qiwei Decoction (HTQD) can effectively treat hypertensive erectile dysfunction (ED), but its exact mechanism of action is not yet clear. The goal of this research was to explore the potential mechanism of HTQD in improving hypertensive erectile dysfunction in rats through transcriptomics, network pharmacology, and associated animal experimentations.

Methods: The HTQD chemical constituents were screened using high-performance liquid chromatography- tandem mass spectrometry (HPLC-MS/MS).

Correction: DNAH11 compound heterozygous variants cause heterotaxy and congenital heart disease.

[This corrects the article DOI: 10.1371/journal.pone.

Bioinformatics Combined With Experimental Modeling to Study the Molecular Mechanism of Xuefu Zhuyu Decoction to Improve Erectile Dysfunction Associated With Asthma in Rats.

Asthma is associated with chronic systemic inflammation, and inflammatory factors can damage vascular endothelial cells, thus impairing erectile function (ED). Xuefu Zhuyu decoction (XFZYD) can inhibit inflammation and promote angiogenesis, which in turn improves asthma as well as ED, but its exact mechanism of action is not yet clear. This study investigates the mechanism underlying the beneficial effect of XFZYD on asthma-associated ED.

Pilot-scale experimental study on the enhanced natural attenuation of complex organic contaminants based on the recharge of electron acceptors.

Anaerobic biodegradation plays a crucial role in attenuating organic contaminants in natural aquifers, where the concentration and type of electron acceptors directly determine the stages and rates of degradation progress. In this study, nitrate depletion was monitored in a simulated pilot-scale aquifer contaminated with toluene and trichloroethylene, while sulfate became the new periodic electron acceptor, accompanied by a decrease in the contaminant attenuation rate. Consequently, nitrate was injected into the contaminated plume in stages, and the hydro- and biochemical impacts were further monitored.

Triglyceride Glucose Index and the Risk of Diabetic Nephropathy in Patients with Type 2 Diabetes: A Meta-Analysis.

Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in patients with type 2 diabetes mellitus (T2DM). This meta-analysis aims to evaluate the association between the triglyceride glucose (TyG) index, a novel marker reflecting insulin resistance, and the risk of developing DN in patients with T2DM. We conducted a comprehensive literature search in PubMed, Embase, and Web of Science databases up to May 12, 2024.

Genus-wide analysis of antagonism toward and plant pathogens and the contribution of cellulases to the antagonism.

Parasitism is an important lifestyle in the genus but has not been studied in a genus-wide way toward and hosts. Our approach screened a genus-wide set of 30 species in dual culture assays with two soil-borne and three plant-parasitic species and used exo-proteomic analyses, with the aim to correlate antagonism with potential strategies for attacking and . The spp.

Unlocking the potential of surface modification with phosphate on ball milled zero-valent iron reactivity:Implications for radioactive metal ions removal.

Numerous investigations have illuminated the profound impact of phosphate on the adsorption of uranium, however, the effect of phosphate-mediated surface modification on the reactivity of zero-valent iron (ZVI) remained enigmatic. In this study, a phosphate-modified ZVI (P-ZVI) was prepared with a facile ball milling strategy, and compared with ZVI, the U(VI) removal amount (435.2 mg/g) and efficiency (3.

Enhanced Uranium Extraction via Charge Dynamics and Interfacial Polarization in MoS/GO Heterojunction Electrodes.

The removal of uranyl ions (UO ) from water is challenging due to their chemical stability, low concentrations, complex water matrix, and technical limitations in extraction and separation. Herein, a novel molybdenum disulfide/graphene oxide heterojunction (MoS/GO-H) is developed, serving as an effective electrode for capacitive deionization (CDI). By combining the inherent advantages of electroadsorption and electrocatalysis, an innovative electroadsorption-electrocatalysis system (EES) strategy is introduced.

Co-migration behavior of toluene coupled with trichloroethylene and the response of the pristine groundwater ecosystems - A mesoscale indoor experiment.

Experimental scale and sampling precision are the main factors limiting the accuracy of migration and transformation assessments of complex petroleum-based contaminants in groundwater. In this study, a mesoscale indoor aquifer device with high environmental fidelity and monitoring accuracy was constructed, in which dissolved toluene and trichloroethylene were used as typical contaminants in a 1.5-year contaminant migration experiment.

Core-Shell MnFe Nanocatalyst Derived from Prussian Blue Analogs for Peroxymonosulfate Activation: Nonradical Mechanism and Bimetallic Valence Cycle.

Sulfamethazine (SAT) is widely present in sediment, soil, rivers, and groundwater. Unfortunately, traditional water treatment technologies are inefficient at eliminating SAT from contaminated water. Therefore, developing an effective and ecologically friendly treatment procedure to effectively remove SAT is critical.

Growth, Enzymatic, and Transcriptomic Analysis of Deletion Reveals a Major Regulator of Plant Biomass-Degrading Enzymes in .

The regulation of plant biomass degradation by fungi is critical to the carbon cycle, and applications in bioproducts and biocontrol. is an important plant biomass degrader, enzyme producer, and biocontrol agent, but few putative major transcriptional regulators have been deleted in this species. The .

YBX1 promotes type H vessel-dependent bone formation in an m5C-dependent manner.

RNA-binding proteins (RBPs) interact with RNA and ubiquitously regulate RNA transcripts during their life cycle, playing a fundamental role in the progression of angiogenesis-related diseases. In the skeletal system, endothelium-dependent angiogenesis is indispensable for bone formation. However, the role of RBPs in endothelium-dependent bone formation is unclear.

Ceftazidime-avibactam versus polymyxins in treating patients with carbapenem-resistant Enterobacteriaceae infections: a systematic review and meta-analysis.

Objective: Carbapenem-resistant Enterobacteriaceae (CRE) pose a significant threat to human health and have emerged as a major public health concern. We aimed to compare the efficacy and the safety of ceftazidime-avibactam (CAZ-AVI) and polymyxin in the treatment of CRE infections.

Methods: A systematic review and meta-analysis was performed by searching the databases of EMBASE, PubMed, and the Cochrane Library.

Natural phosphorus-ferromanganese ore-based composites for the simultaneous remediation of arsenic- and lead-co-contaminated groundwater: synergistic effectiveness, kinetics, and mechanisms.

Natural phosphorus-ferromanganese ore (NPO-NFMO) based composites by mechanical ball milling method, applying for the simultaneous remediation of arsenic (As) and lead (Pb) co-contaminated groundwater. Kinetic behavior adopted pseudo-second-order adsorption mechanism attaining equilibrium in 120 min over a wide pH range (2.0-6.

Identification of novel compound heterozygous variants in the gene of a Chinese family with left-right asymmetry disorder.

Most internal organs in humans and other vertebrates exhibit striking left-right asymmetry in position and structure. Variation of normal organ positioning results in left-right asymmetry disorders and presents as internal organ reversal or randomization. Up to date, at least 82 genes have been identified as the causative genetic factors of left-right asymmetry disorders.

Genetically predicted hypertension, antihypertensive drugs, and risk of erectile dysfunction: a Mendelian randomization study.

Background: The causal relationship between hypertension, antihypertensive drugs and the risk of erectile dysfunction is still uncertain. We performed a univariable and multivariable Mendelian randomization study to investigate whether they are causally related to erectile dysfunction.

Methods: Genetic variants associated with blood pressure were derived from the genome-wide association study meta-analysis of the UK Biobank and International Consortium of Blood Pressure ( = 757,601).

Cardioprotective effect of curcumin on myocardial ischemia/reperfusion injury: a meta-analysis of preclinical animal studies.

This meta-analysis aimed to determine the efficacy of curcumin in preventing myocardial ischemia/reperfusion (I/R) injury in animal models. Studies published from inception to January 2023 were systematically searched in databases including PubMed, Web of Science, Embase, China's National Knowledge Infrastructure (CNKI), Wan-Fang database, and VIP database (VIP). The SYRCLE's RoB tool was used to determine methodological quality.

Characteristics of persulfate gel materials in groundwater remediation: Column and tank experiments investigations.

Using persulfate and environment-friendly gel solution as raw materials, persulfate gel sustained-release material (PGSR) and persulfate gelatin gel sustained-release material (G-PGSR) were developed. The main purpose of this study was to evaluate the potential of PGSR and G-PGSR in sustained release, migration and removal performance through column and tank experimental investigations. Results showed that the maximum release rates of PGSR and G-PGSR in water columns were 1.

A novel thermosensitive persulfate controlled-release hydrogel based on agarose/silica composite for sustained nitrobenzene degradation from groundwater.

The increasing risk of organic contamination of groundwater poses a serious threat to the environment and human health, causing an urgent need to develop long-lasting and adaptable remediation materials. Controlled-release materials (CRMs) are capable of encapsulating oxidants to achieve long-lasting release properties in aquifers and considered to be effective strategies in groundwater remediation. In this study, novel hydrogels (ASGs) with thermosensitive properties were prepared based on agarose and silica to achieve controlled persulfate (PS) release.

Efficient utilization of biogenic manganese oxides in bioaugmentation columns for remediation of thallium(I) contaminated groundwater.

Little attention has been paid to the in situ-generated biogenic manganese oxides (BMnOx) for practical implementation in continuous groundwater remediation systems. The enrichment effects of manganese oxidizing bacteria (MOB) in bioaugmentation columns and the in situ-generated BMnOx for continuous thallium(I) (Tl(I)) removal from groundwater were investigated. Results indicated that Pseudomonas Putida MnB1 (strain MnB1) attached on the groundwater sediments (GS) can achieve a maximum of 97.