Publications by authors named "Sheng Chen Han"
Purpose: To investigate the effect of recombinant human parathyroid hormone (rhPTH) biocomposite on bone-to-tendon interface (BTI) healing for surgical repair of a chronic rotator cuff tear (RCT) model of rabbit, focusing on genetic, histologic, biomechanical and micro-computed tomography (CT) evaluations.
Methods: Sixty-four rabbits were equally assigned to the 4 groups: saline injection (group A), nanofiber sheet alone (group B), rhPTH-soaked nanofiber sheet (nanofiber sheet was soaked with rhPTH, group C), and rhPTH biocomposite (rhPTH permeated the nanofiber sheet by coaxial electrospinning, group D). The release kinetics of rhPTH (groups C and D) was examined for 6 weeks in vitro.
Article Synopsis
- The study investigates the effectiveness of bioactive scaffolds that deliver growth factors over time to improve the healing of the bone-to-tendon interface (BTI) after rotator cuff repair.
- Conducted on 50 rabbits with chronic rotator cuff tears, the research compares outcomes between groups receiving saline, scaffolds without growth factors, and scaffolds with growth factors.
- Results show that scaffolds with growth factors led to significantly better healing, with higher mRNA expression of important collagen types, improved matrix formation, and stronger mechanical properties at the BTI compared to the other treatments.