[A prognosis scale for functional outcome at discharge after endovascular thrombectomy in the carotid artery territory].

Objective: To develop a method for early (24 hrs after intervention) prognosis of functional outcome at discharge in patients after endovascular thrombectomy (EVT) in anterior cerebral circulation based on NIHSS.

Material And Methods: A retrospective analysis of endovascular treatment in 362 acute stroke patients (189 men, 173 women, median age 69 years) with anterior circulation large vessel occlusion was performed in the regional vascular centers of St. Petersburg.

[Retrospective analysis of endovascular thrombectomy in anterior cerebral circulation out of 6-hours «therapeutic window» in regional vascular centers of Saint-Petersburg].

Objective: Based on a retrospective analysis, to evaluate technical results and functional outcomes at discharge after endovascular thrombectomy (EVT) in anterior circulation out of 6-hours «therapeutic window» in patients with stroke.

Material And Methods: The retrospective analysis of EVT in 594 acute stroke patients (303 male, 291 female, median age 69 years) with the anterior circulation large vessel occlusion was performed. EVT was carried out before 6 hrs in 550, later in 44 patients.

[Outcomes of endovascular thrombectomy for acute stroke in regional vascular centers of a metropolis (St.-Petersburg)].

Aim: To assess technical results and close functional outcomes of acute ischemic stroke (AIS) in patients treated with endovascular thrombecomy (ET) in regional vascular centers (RVC) of St-Petersburg.

Material And Methods: Retrospective analysis of 183 patients with AIS, including 143 patients with AIS due to a large intracranial vessel occlusion in anterior (AC) and 25 patients in posterior cerebral (PC) circulation, 15 with isolated extracranial carotid occlusion treated in 6 RVC in 2017 was performed. All patients underwent ET.

[Changes in the efficacy of vasoconstrictor stimuli in acute and chronic hypotension in the microcirculatory bed of rat skeletal muscle].

Microvascular diameters in m. extensor hallucis proprius of rats were measured by the image split method. The baseline diameters and responses to the electrical stimulation (20 Hz, 10 s) of the sympathetic tract were obtained in arterioles i.

[Constrictor reaction to transmural electric stimulation of the isolated femoral artery and its branches in chronic arterial hypotension].

Chronic regional arterial hypotension in the hind limbs of rats was produced by narrowing of the abdominal aorta. 14-19 days later the femoral artery and its main branches were isolated and perfused in vitro with oxygenated Krebs' solution. It was shown that constrictor responses to transmural electrical stimulation decreased 14-30 days after the constriction of the aorta, however, 90 days after the operation the responses were identical to those in the control.

[Changes in the microcirculatory bed and tissue metabolism in chronic regional arterial hypotension].

Blood pressure was reduced in the hind part of rats by narrowing the aorta in regions distal to renal artery ostium. Resetting of microcirculatory bed (m. extensor hallicis propius) was revealed in arterial hypotension, characterized by resistance vessel dilatation ensuring the decrease in hydravlic resistance, thus facilitating blood supply and tissue metabolism normalization, irrespective of marked reduction in perfusion pressure.

[Effect of long-term arterial hypotension on the relative volume of functioning capillaries in working skeletal muscles].

In control rats, the relative red cell volume, mirroring the number of the functioning capillaries, was substantially greater in the soleus than in the gastrocnemius muscle, while the rise of this parameter seen during contraction of both the muscles, provoked by stimulation of the sciatic nerve, amounted to 37 and 54%, respectively. Fourteen days and 3-4 months after abdominal aorta constriction by a metal spiral, that produced a 30-50% lowering of the blood pressure in the vessels of the animal's body posterior, contractions of the gastrocnemius muscle did not provoke any increase in the relative red cell volume, whereas contractions of the soleus muscle were accompanied by a marked elevation of the relative red cell volume. It is assumed that the mechanisms underlying the working hyperemia of the gastrocnemius and soleus muscles are different.

[Relative volume of open capillaries in the skeletal muscles of rats with chronic local arterial hypotension].

A modification of Pickworth's method for detection of open capillaries was used. The modification is based on freezing an organ in situ with liquid propane, cooled with liquid nitrogen, followed by lyophilization of the preparation and its fixation in gaseous formaldehyde. It was shown in rat experiments that the number of functioning capillaries in m.

[Orthostatic circulatory instability: role of deconditioning of resistance vessels].

One of the effects of weightlessness on the circulatory system, i.e. reduction of the tension distending resistance vessels due to the loss of hydrostatic pressure, was simulated.

[Neurohistochemical and ultrastructural study of the adrenergic innervation of the wall of the rat posterior vena cava during chronic venous hypertension caused by experimental oleothorax].

Chronic venous hypertension in rats was provoked by injection of polymethyloxane into the pleural cavity. Hypertrophy of muscular tissue was accompanied by reconstitution of adrenergic nervous structures. In the early stages (up to 40 days), the changes in the latter are reactive in nature: first there occurs a weakening of luminescence, rare-fraction of the network and then "hyperneuria".

[Ultrastructure of the wall of the femoral artery in rats with chronic regional arterial hypotension].

In experiments on rats a lowering of the arterial pressure in the vessels of the body posterior was attained by occlusion of the aorta distally to the ostia of renal arteries. Twelve days after the operation there occurred a significant thinning out of the muscle layer and intermuscular septa in the wall of the femoral artery. Also, there was a disappearance of extracellular matrix vesicles usually seen in great numbers in tunica media of the artery.

[Improvement in the histochemical method of detecting open capillaries].

A modification of Pickworth's method for detection of open capillaries is described. The special feature of this method consists in freezing the organ in situ with liquid propane, cooled with liquid nitrogen, with the subsequent lyophilization of the preparation and its fixing in gazeous formaldehyde. The slides were stained strictly according to Pickworth.

[Relative volume of functioning capillaries in the skeletal muscle in regional hypotension].

Experiments on rats demonstrated that one month after the reduction of pressure in the vessels of the hind part of the body caused by narrowing of the abdominal aorta lumen the number of functioning capillaries in the gastrocnemius and the soleus muscles was practically the same as in control animals. These results allowed the authors to assume that a decrease of the hydraulic resistance of the resistive vessels in the area of chronic local arterial hypotension was not connected with an increase in the number of parallelly functioning vessels.

[Volume rigidity of the capacitance vessels of rats in local arterial hypotension].

It was shown in experiments on rats that reduction of arterial pressure in the vessels of the posterior extremity for a period of up to three months was accompanied by a decrease of the volume stiffness of the capacitance vessels of this area.