Publications by authors named "Shen-Tao Wang"
Article Synopsis
- Cisplatin induces acute kidney injury (AKI) through mitochondrial damage and apoptosis, necessitating effective treatments.
- The compound (+)-14,15-Dehydrovincamine, derived from Vincamine, has been found to significantly improve mitochondrial function and reduce apoptosis in renal tubular cells affected by cisplatin-induced AKI.
- The protective mechanism of (+)-14,15-Dehydrovincamine involves inhibiting the JNK/Mff/Drp1 pathway, which helps maintain mitochondrial stability and reduces cell death during AKI.
Depression, one of the most common comorbidities with osteoarthritis (OA), affects patient prognosis and quality of life. It also increases the overall burden of disease. This subgroup of patients has not been effectively managed in clinical settings.
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- Knee osteoarthritis (KOA) leads to pain and reduced quality of life, and resistance training is suggested to combat muscle weakness in affected patients.
- This study aims to assess the impact of varying degrees of blood flow restriction (BFR) during low-load resistance training on pain, function, and overall quality of life in KOA patients.
- Participants will be randomly divided into groups with different levels of BFR and will engage in strength training over 12 weeks, with outcomes measured to determine the most effective approach for improving symptoms and function.