Unraveling Dynamic Structural Evolution of Single Atom Catalyst Surface-Enhanced Infrared Absorption Spectroscopy.

Metal-nitrogen-carbon (M-N-C) single-atom catalysts (SACs) have been widely applied in catalyzing electrochemical redox reactions. However, their long-term catalytic stabilities greatly limit their practical applications. This work investigates the dynamic evolution of two model Cu-N-C SACs with different Cu-N coordinations, namely the Cu/N-C and Cu/N-C, in electrochemical CO reduction reaction (CORR), based on a collection of characterizations including attenuated total reflectance surface-enhanced infrared absorption spectroscopy, X-ray absorption spectroscopy, electron paramagnetic resonance spectroscopy and ultraviolet-visible spectroscopy, complemented by theoretical calculations.

Self-luminescent dual-ligand metal-organic framework based electrochemiluminescence probes for organophosphorus pesticides determination.

In this study, a signal amplification strategy was developed, which tris (2, 2'-bipyridyl) ruthenium (II) (Ru(bpy)) was incorporated as a guest molecule into the preparation system of lanthanide-based metal-organic framework (MOF). This strategy relied on strong electrostatic interactions and coordination competition to influence the growth process of the MOF, resulting in the firm immobilization of Ru(bpy) within the MOF structure. The spatial confinement effect of the MOF effectively improved the efficiency of electron transfer in the electrochemiluminescence (ECL) reaction.

Fructose induces inflammatory activation in macrophages and microglia through the nutrient-sensing ghrelin receptor.

High fructose corn syrup (HFCS) is a commonly used sweetener in soft drinks and processed foods, and HFCS exacerbates inflammation when consumed in excess. Fructose, a primary component of HFCS; however, it is unclear whether fructose directly activates inflammatory signaling. Growth hormone secretagogue receptor (GHSR) is a receptor of the nutrient-sensing hormone ghrelin.

Knockdown gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation.

Doxorubicin (DOX) is a prevalent chemotherapeutic drug for treating several malignancies. However, the mechanisms of DOX induced cardiac toxicity is not fully understood. Previous studies have demonstrated that autophagy activation is essential in DOX-induced cardiac toxicity.

Comparison and prediction of shallow groundwater nitrate in Shaying River basin based on urban distribution using multiple machine learning approaches.

Groundwater, a pivotal water resource in numerous regions worldwide, confronts formidable challenges posed by severe nitrate pollution. Traditional research methodologies aimed at addressing groundwater nitrate contamination frequently struggle to accurately depict the intricate conditions of the groundwater environment, particularly when dealing with high variability and nonlinear data. However, the advent of machine learning (ML) has heralded an innovative approach to simulating groundwater dynamics.

Increases in the susceptibility of human endometrial CD4 T cells to HIV-1 infection post-menopause are not dependent on greater viral receptor expression frequency.

Epidemiological evidence suggests that post-menopausal women are more susceptible to HIV infection following sexual intercourse than are younger cohorts for reasons that remain unclear. Here, we evaluated how menopause-associated changes in CD4 T cell numbers and subsets as well as HIV coreceptor expression, particularly CCR5, in the endometrium (EM), endocervix (CX), and ectocervix (ECX) may alter HIV infection susceptibility. Using a tissue-specific mixed cell infection model, we demonstrate that while no changes in CD14 macrophage infection susceptibility were observed, CD4 T cell HIV-1 infection frequency increases following menopause in the EM, but not CX nor ECX.

Hypothyroidism induced by excessive-iodine is associated in humans with altered hsa-miR-199a-5p/HIF-1α axis and thyroglobulin.

The adverse effect of excessive iodine intake has attracted extensive attention. However, the role of excessive iodine on hypothyroidism and detailed mechanism are not exactly known. Studies have shown that miRNAs are crucial to the occurrence and development of hypothyroidism.

Aging Selectively Alters PRR and ISG Expression in Endo- and Ecto-Cervical Stromal Fibroblasts From the Human Female Reproductive Tract.

Problem: Aging alters immune function in women and can lead increased risk of infections, particularly in the female reproductive tract (FRT).

Method Of Study: To determine how aging affects innate immune responses in the cervical stroma of the FRT, we isolated endocervical (CX) and ectocervical (ECX) stromal fibroblasts and determine if their expression of multiple pattern recognition receptors (PRRs) and responses to viral stimulation varied with menopause and age.

Results: Constitutive expression of most PRRs did not vary with age or menopausal status in either cell type.

Proteinase K impact on anaerobic co-digestion of modified biodegradable plastic and food waste: Step-by-step analysis with microorganism.

This study was designed to explore the key impact of Proteinase K (PK) on every step of anaerobic co-digestion. The results of step-by-step experiments indicated that PK promoted the hydrolysis of biodegradable plastic by initiating self-hydrolysis reactions, directly promoting the hydrolysis step of anaerobic co-digestion. Subsequently, PK indirectly promoted the acidogenesis and acetogenesis steps by impacting the proliferation of acid-producing bacteria.

Potentiating CAR-T cell function in the immunosuppressive tumor microenvironment by inverting the TGF-β signal.

The immunosuppressive tumor microenvironment represents a key challenge for chimeric antigen receptor (CAR) T cells in solid tumors and includes the production of the inhibitory cytokine transforming growth factor β (TGF-β), which limits CAR-T cell persistence and function. Current strategies involving the blockade of TGF-β signaling have little benefit for solid tumor treatment. Here, we demonstrate a novel inverted cytokine receptor (ICR)-modified CAR-T cell strategy not only TGF-β signal blockade but also antitumor efficacy enhancement.

Effective Improvement of Thermodynamics and Kinetics of BiVO Photoanode via CuI for Photoelectrochemical Water Oxidation.

The preparation of durable and efficient photoanodes for photoelectrochemical water oxidation is of great importance in promoting the development of green hydrogen production and artificial photosynthesis. Here, n-type BiVO was combined with p-type CuI to construct a CuI/BiVO (CIB-1) p-n heterojunction photoanode. The composite photoanode effectively overcame the drawbacks of BiVO, such as low separation and injection efficiency of photogenerated electron-hole pairs.

Foliar application of zinc and selenium regulates cell wall fixation, physiological and gene expression to reduce cadmium accumulation in rice grains.

Zinc (Zn) and selenium (Se) are beneficial elements for crops, enhancing crop quality and alleviating heavy metal toxicity. However, there is limited research on the role of foliar Zn and Se in the mechanism of reducing cadmium (Cd) uptake in crops. A field experiment was conducted to investigate the effect on subcellular distribution, leaf antioxidant enzyme activities, and the transcriptional regulation in the process of Cd accumulation of rice grains after foliar applications of Zn, Se, and their mixed solutions (ZnSe).

Real-world outcomes in patients with brain metastases secondary to HR+/HER2- MBC treated with abemaciclib and local intracranial therapy.

Background: Real-world data are limited for patients with brain metastases secondary to metastatic breast cancer (MBC) and treated with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i). This study describes real-world outcomes in patients with hormone receptor-positive, human epidermal growth factor 2-negative (HR+/HER2-) MBC with brain metastases diagnosis before abemaciclib initiation.

Patients And Methods: A nationwide electronic health record-derived de-identified MBC database (January 2011-December 2021) was assessed retrospectively.

The influence of genotype makeup on the effectiveness of growth hormone therapy in children with Prader-Willi syndrome.

Background: Prader-Willi syndrome (PWS) is a rare multisystemic hereditary illness. Recombinant human growth hormone (rhGH) therapy is widely recognized as the primary treatment for PWS. This study aimed to examine how different PWS genotypes influence the outcome of rhGH treatment in children with PWS.

Impact of aging on the frequency, phenotype, and function of CD4+ T cells in the human female reproductive tract.

Since CD4+ T cells are essential for regulating adaptive immune responses and for long lasting mucosal protection, changes in CD4+ T cell numbers and function are likely to affect protective immunity. What remains unclear is whether CD4+ T cell composition and function in the female reproductive tract (FRT) changes as women age. Here we investigated the changes in the composition and function of CD4+ T cells in the endometrium (EM), endocervix (CX), and ectocervix (ECX) with aging.

La@BC500-SO system for removal of sulfonamide antibiotics in water.

Sulfonamide antibiotics (SAs) widely used have potentially negative effects on human beings and ecosystems. Adsorption and advanced oxidation methods have been extensively applied in SAs wastewater treatment. In this study, compared with Al@BC500 and Fe@BC500, La@BC500 for activating persulfate (SO) had the best effect removal performance of sulfadiazine (SDZ) and sulfamethoxazole (SMX).

BF170 hydrochloride enhances the emergence of hematopoietic stem and progenitor cells.

Generation of hematopoietic stem and progenitor cells (HSPCs) ex vivo and in vivo, especially the generation of safe therapeutic HSPCs, still remains inefficient. In this study, we have identified compound BF170 hydrochloride as a previously unreported pro-hematopoiesis molecule, using the differentiation assays of primary zebrafish blastomere cell culture and mouse embryoid bodies (EBs), and we demonstrate that BF170 hydrochloride promoted definitive hematopoiesis in vivo. During zebrafish definitive hematopoiesis, BF170 hydrochloride increases blood flow, expands hemogenic endothelium (HE) cells and promotes HSPC emergence.

Molecular tuning boosts asymmetric C-C coupling for CO conversion to acetate.

Electrochemical carbon dioxide/carbon monoxide reduction reaction offers a promising route to synthesize fuels and value-added chemicals, unfortunately their activities and selectivities remain unsatisfactory. Here, we present a general surface molecular tuning strategy by modifying CuO with a molecular pyridine-derivative. The surface modified CuO nanocubes by 4-mercaptopyridine display a high Faradaic efficiency of greater than 60% in electrochemical carbon monoxide reduction reaction to acetate with a current density as large as 380 mA/cm in a liquid electrolyte flow cell.

Enzyme modified biodegradable plastic preparation and performance in anaerobic co-digestion with food waste.

A modified biodegradable plastic (PLA/PBAT) was developed by through covalent bonding with proteinase K, porcine pancreatic lipase, or amylase, and was then investigated in anaerobic co-digestion mixed with food waste. Fluorescence microscope validated that enzymes could remain stable in modified the plastic, even after co-digestion. The results of thermophilic anaerobic co-digestion showed that, degradation of the plastic modified with Proteinase K increased from 5.

Enhanced adsorption of dye wastewater by low-temperature combined NaOH/urea pretreated hydrochar: Fabrication, performance, and mechanism.

The highly stable biomass structure formed by cellulose, hemicellulose, and lignin results in incomplete conversion and carbonization under hydrothermal conditions. In this study, pretreated corn straw hydrochar (PCS-HC) was prepared using a low-temperature alkali/urea combination pretreatment method. The Mass loss rate of cellulose, hemicellulose, and lignin from pretreated biomass, as well as the effects of the pretreatment method on the physicochemical properties of PCS-HC and the adsorption performance of PCS-HC for alkaline dyes (rhodamine B and methylene blue), were investigated.

Interaction Effects between the Main Components of Protein-Rich Biomass during Microwave-Assisted Pyrolysis.

The interaction effects between the main components (proteins (P), carbohydrates (C), and lipids (L)) of protein-rich biomass during microwave-assisted pyrolysis were investigated in depth with an exploration of individual pyrolysis and copyrolysis (PC, PL, and CL) of model compounds. The average heating rate of P was higher than those of C and L, and the interactions in all copyrolysis groups reduced the max instant heating rate. The synergistic extent () of PC and PL for bio-oil yield was 16.

Co-impacts of cation type and humic acid on migration of polystyrene microplastics in saturated porous media.

The aging process of microplastics (MPs) could significantly change their physical and chemical characteristics and impact their migration behavior in soil. However, the complex effects of different cations and humic acids (HA) on the migration of aged MPs through saturated media are not clear. In this research, the migration and retention of pristine/aged PSMPs (polystyrene microplastics) under combined effects of cations (Na, Ca) (ionic strength = 10 mM) and HA (0, 5, 15 mg/L) were investigated and analyzed in conjunction with the two-site kinetic retention model and DLVO theory.