The nonlinear correlation between total bilirubin and lumbar spine bone mineral density in patients receiving maintenance hemodialysis.

Background: Patients receiving maintenance hemodialysis (MHD) are at increased risk of osteoporosis. The effects of bilirubin on bone metabolism vary among different disease populations. However, the relationship between total bilirubin (TBIL) and bone metabolism in MHD has not been investigated yet.

A ratiometric fluorescence sensor for detection of organophosphorus pesticides based on enzyme-regulated multifunctional Fe-based metal-organic framework.

The residues of organophosphorus pesticides (OPs) are increasing environmental pollution and public health concerns. Thus, the development of simple, convenient and sensitive method for detection of OPs is crucial. Herein, a multifunctional Fe-based MOF with fluorescence, catalytic and adsorption, is synthesized by a simple one-pot hydrothermal method.

A highly selective dual-signal response ratiometric fluorescence sensing strategy for malachite green in fish based on carbon dots/copper nanoclusters nanocomposite.

Malachite green (MG), a widely used antiparasitic agent, poses health risks to human due to its genotoxic and carcinogenic properties. Herein, a stable dual-emission fluoroprobe of carbon dots/copper nanoclusters is prepared for highly selective detection of MG based on the inner filter effect. This probe exhibits characteristic emission bands at 435 and 625 nm when excited at 376 nm.

Advances in Pediatric Toe Transfers.

Microsurgery is undoubtedly the pinnacle of hand surgery. Significant advancement in recent years has stretched the indications for toe-to-hand transfer in both acquired and congenital hand defects to restore function, esthetics, and motion, with minimal morbidity to the donor site. There is no one fixed microsurgical transfer technique but a surgeon's versatility and innovation in using what one could spare because each case is unique.

Covalent organic framework reinforced hollow fiber bar for extraction and detection of bisphenols from beverages.

Bisphenols (BPs) can migrate from packaging materials into foods, resulting in potentially harmful residues. For example, accumulation of BPs is associated with endocrine disorders. Owing to matrix effects, development of an effective and eco-friendly sample pretreatment would be helpful for BPs detection in beverages packed in plastic containers.

Covalent organic framework-sodium alginate-Ca-polyacrylic acid composite beads for convenient dispersive solid-phase extraction of neonicotinoid insecticides in fruit and vegetables.

Neonicotinoids, the fastest-growing class of insecticides, have posed a multi-media residue problem with adverse effects on environment, biodiversity and human health. Herein, covalent organic framework-sodium alginate-Ca-polyacrylic acid composite beads (CACPs), facilely prepared at room temperature, were used in convenient dispersive solid-phase extraction (dSPE) and combined with high-performance liquid chromatography (HPLC) for the detection of five neonicotinoid insecticides (thiamethoxam, acetamiprid, dinotefuran, clothianidin, imidacloprid). CACPs can be completely separated within 1 min without centrifugation.

A colorimetric sensing platform with smartphone for organophosphorus pesticides detection based on PANI-MnO nanozyme.

Organophosphorus pesticides (OPs) are of great concern due to its potential harms on human health and the environment. Herein, a budget-friendly, rapid and convenient colorimetric sensing platform is developed for detection of OPs in the environmental and food samples. The sensing element, PANI-MnO nanozyme with excellent oxidase mimetic activity is synthesized at room temperature, which is able to directly oxidize 3,3,5,5-tetramethylbenzidine (TMB) to generate blue colored oxidized TMB (OxTMB) within 2 min.

Membrane-protected magnetic covalent organic framework for efficient extraction of estrogens in dairy products.

The presence of estrogens residues in dairy products is a growing concern due to their potential health risk. Herein, in this study, we have developed a membrane-protected magnetic solid-phase extraction (MP-MSPE) method that utilized a magnetic adsorbent (FeO@COF-LZU1) with in-situ growth for the efficient extraction of estrone (E1), 17β-estradiol (E2), and estriol (E3). When combined with HPLC-FLD, this method allows for the efficient detection of estrogens in dairy products.

Electrochemical oxidation diminished toxicity of zearalenone significantly, while reduction increased.

Zearalenone (ZEN), one of the most common mycotoxins in cereals, poses a severe health risk to humans. In this study, electrochemical oxidation and reduction degraded ZEN in solution completely within 8 min and 20 min. The structure of ZEN products was elucidated by mass spectrometry (MS), and their toxicity was evaluated by ECOSAR software and cytotoxicity assay.

Fabrication of β-cyclodextrin-polyacrylamide/covalent organic framework hydrogel at room temperature for the efficient removal of triazole fungicides from environmental water.

Triazole is frequently-used fungicide, which can leach into surface water through farmland and cause serious environmental pollution. Continuous exposure to triazole fungicides may cause harm to human health. Herein, β-cyclodextrin-polyacrylamide/covalent organic framework (β-CD-PAAM/TFPB-BD) hydrogel was fabricated at room temperature and used for the efficient removal of triazole fungicides.

Ratio fluorescence test strip visualized by amino-functionalized metal-organic framework for rapid sensing of glyphosate.

As glyphosate is a broad-spectrum herbicide extensively used in agriculture worldwide, rapid glyphosate detection is essential for food safety and human health. Herein, a ratio fluorescence test strip was prepared and coupled with an amino-functionalized bismuth-based metal-organic framework (NH-Bi-MOF) that bonded with copper ion for rapid visualization and determination of glyphosate. NH-Bi-MOF had excellent fluorescence performance, and the copper ion, a Lewis acid, was selected as the quencher.

Bismuth-based metal-organic framework peroxidase-mimic nanozyme: Preparation and mechanism for colorimetric-converted ultra-trace electrochemical sensing of chromium ion.

A colorimetric-electrochemical dual-mode analytical method based on bismuth metal-organic framework nanozyme was developed for label-free and trace/ultra-trace Cr detection. 3D ball-flower shaped bismuth oxide formate (BiOCOOH) was used as the precursor and template to facilely construct the metal-organic framework nanozyme BiO-BDC-NH, which possesses intrinsic peroxidase-mimic activity to effectively catalyze the colorless 3,3',5,5'-tetramethylbenzidine into blue oxidation products in the presence of hydrogen peroxide. Based on Cr to promote the peroxide-mimic activity of BiO-BDC-NH nanozyme, a colorimetric method for Cr detection was developed with the detection limit of 0.

Paper-based analytical device coupled with Bi-MOF: Electric field amplification and fluorescence sensing of glyphosate.

Glyphosate, a potent herbicide wildly used in the world, involves potential hazards to human health by accumulating in the food chain. Due to its absence of chromophores and fluorophores, the rapid visual detection of glyphosate has always been difficult. Herein, a paper-based geometric field amplification device visualized by the amino-functionalized bismuth-based metal-organic framework (NH-Bi-MOF) was constructed for sensitive fluorescence determination of glyphosate.

Magnetic covalent organic frameworks for rapid solid-phase extraction of phthalate esters and bisphenol A in beverage samples.

Phthalate esters (PAEs) and bisphenol A (BPA) are endocrine-disrupting chemicals (EDCs), which are widely used in the production of food plastic packaging and easily migrate to food. Continuous exposure to EDCs may cause harm to human health. Herein, magnetic covalent organic framework TFP-NDA/FeO was synthesized by magnetizing covalent organic framework TFP-NDA through a facile coprecipitation method, and used as an adsorbent for rapid solid-phase extraction of PAEs (diethyl phthalate (DEP), diisobutyl phthalate (DIBP) and dibutyl phthalate (DBP)) and BPA.

Covalent organic framework in situ grown on FeO hollow microspheres for stir bar sorptive-dispersive microextraction of triazole pesticides.

Based on covalent organic framework (COF) 1,3,5-tris-(4-formylphenyl)benzene-benzidine (TFPB-BD) in situ grown on FeO hollow microspheres and combined with gas chromatography-flame thermionic detector, a rapid and simple stir bar sorptive-dispersive microextraction method was developed for the determination of five triazole pesticides (paclobutrazol, hexaconazole, flusilazole, propiconazole, and tebuconazole). The synthesized TFPB-BD/FeO microspheres were characterized by transmission electron microscope, vibrating sample magnetometer, and thermogravimetric analysis, which showed that the material has strong magnetism and higher load capacity of COF. Under optimal conditions, the extraction equilibrium could be achieved within 9 min with detection limits of 0.

Electro-enhanced solid-phase microextraction with membrane protection for enrichment of bisphenols in canned meat.

Bisphenols (BPs), one of the endocrine disrupting chemicals (EDCs), are harmful to health with the potential carcinogenicity, teratogenicity and neurotoxicity. In this paper, we developed an electro-enhanced solid-phase microextraction with membrane protection method to enrich BPs. The extraction time can be shortened to 10 min with the electric field, and the prepared fiber can be repetitively used 100 times with the membrane protection.

Congenital difference of the hand and foot: Pediatric macrodactyly.

Background: Macrodactyly is a very rare congenital difference that affects hands and feet with significant developmental and psychological implications. Macrodactyly is attributed to a somatic mutation in PIK3CA, a component of the mTOR pathway-related overgrowth disorders. Other medical conditions have been associated with macrodactyly (e.

A stack-up electrochemical device based on metal-organic framework modified carbon paper for ultra-trace lead and cadmium ions detection.

A portable device is conducive to the on-site detection of heavy metal ions at trace level in food and the prevention of related food safety issues. In this work, an electrochemical device stacked up with flat electrodes was developed for the detection of Pb and Cd. The top layer of the device is a carbon paper as working electrode, which is modified with amino functionalized cobalt-based metal-organic framework and gold nanoparticles.

A ratio fluorescence sensor based on rhodamine B embedded metal-organic framework for glyphosate detection in agri-food products.

Glyphosate, a broad-spectrum and high-efficiency herbicide, could accumulate in the human body through the consumption of agri-food products. Herein, a ratio fluorescence sensor based on rhodamine B-embedded amino-functionalized iron-based metal-organic framework (MOF, NH-MIL-88(Fe)@RhB) bonded with Cu was developed for rapid detection of glyphosate. The synthesized NH-MIL-88(Fe) was a biconical prism and had a cavity for the embedding of RhB as a reference compound.

Metal-organic framework modified carbon cloth for electric field enhanced thin film microextraction of sulfonamides in animal-derived food.

Sulfonamides (SAs) were widespread in animal-derived food at trace level, which could trigger hazards to human health. Herein, electric field enhanced thin-film microextraction (EE-TFME) was developed based on carbon cloth (CC) modified with metal-organic frameworks (MOFs) for extraction of SAs (sulfadiazine, sulfathiazole, sulfamerazine, sulfadimidine, sulfamethoxazole and sulfisoxazole), which were a series of polar analytes. MIL-101(Cr) was in situ synthesized on CC via hydrothermal reaction and then was used as positive electrode in EE-TFME for adsorption of SAs.

Covalent organic framework modified carbon cloth for ratiometric electrochemical sensing of bisphenol A and S.

A novel ratiometric electrochemical sensor was developed based on a carbon cloth electrodeposited with silver nanoparticles and drop-coated by covalent organic framework (COF-LZU1) for simultaneous determination of bisphenol A (BPA) and bisphenol S (BPS). Carbon cloth exhibited a significantly larger electrochemical active area than common glassy carbon electrodes (27.5 times).

Thumb and first webspace reconstruction in nonsyndromic congenital mitten hand with symbrachydactyly.

Introduction: Nonsyndromic congenital mitten hand with thumb and index finger syndactyly is rare. Reconstruction of this condition is challenging, requiring repositioning of the thumb and creation of a wide and deep first webspace. The aim of this paper is to describe the characteristics of patients with this condition and also to describe our surgical technique.

Covalent organic framework DQTP modified pencil graphite electrode for simultaneous determination of bisphenol A and bisphenol S.

The sensitivity and selectivity of electrochemical analysis are challenging due to the materials used for electrode modification as well as electrical conductivity, catalytic activity and recognition ability of the working electrode. In this work, a portable 3D-printed electrochemical electrode clamp was designed and applied in combination with the developed covalent organic framework (COF DQTP)-modified pencil graphite electrode (DQTP/PGE). The β-ketoenamine-linked COF DQTP synthesized by 1,3,5-triformylphloroglucinol (TP) and 2,6-diaminoanthraquinone (DQ) through solvothermal method is a porous crystalline with excellent conductivity and large periodic π-arrays, coupled with commercial available pencil graphite electrode to fabricate a disposable sensor for simultaneous determination of environmental endocrine disruptors bisphenol A and bisphenol S.

Collaborative compounding of metal-organic frameworks for dispersive solid-phase extraction HPLC-MS/MS determination of tetracyclines in honey.

Metal-organic frameworks (MOFs), a sort of dispersive solid-phase extraction (d-SPE) material, has shown considerable prospects in the pretreatment of food, biological and other complex samples. Herein, we developed a method for compounding MOFs for d-SPE and trace determination of tetracyclines (TCs) in honey. When the compounding ratio of MIL-101 (Cr), MIL-100 (Fe) and MIL-53 (Al) was 7:1:2, adsorption-extraction was effective.