A privacy-preserving and low-cost system for preventing cheats in in-vehicle alcohol detection.

Objectives: Young people are easily impulsive and influenced by their peers, so they lead to a high crash rate than adults when they consume alcohol. To forcibly prevent them from drunk driving is very important. Therefore, an in-vehicle system for preventing cheats in alcohol detection is innovatively designed according to the driving habits in China.

Leaching-Reconstruction Engineering of Anions on Ferronickel Phosphate Promotes the Enhancement of the Oxygen Evolution Reaction.

Electrochemical reconstruction typically generates powerful active sites for the oxygen evolution reaction (OER). However, engineering effective reconstruction strategies to manipulate the in situ formation of desired catalytically active surfaces, generate powerful active sites, and enhance their catalytic performance remains a challenge. Herein, leveraging the oxidation-potential-assisted precipitation etching, a heterostructure of NiFeOOH/NiFe phosphate was meticulously engineered to achieve highly efficient OER.

Distinct pathways for the absorption and metabolism of β-carotene and zeaxanthin in the mouse intestine.

Carotenoids, essential nutrients for eye health, are absorbed in the intestine to support vitamin A homeostasis and provide cellular protection. This process involves the lipid transporters scavenger receptor class B type 1 (SR-B1, encoded by Scarb1 gene) and Niemann-Pick C1-Like 1 (NPC1L1), which load these dietary lipids into the plasma membrane of intestinal enterocytes. However, the precise contribution of these transporters to carotenoid absorption, the putative involvement of Aster proteins in their downstream movement, and the interactions with their metabolizing enzymes, β-carotene oxygenase 1 (BCO1) and β-carotene oxygenase 2 (BCO2), remain incompletely understood.

GhMYB102 affects cotton fibre elongation and secondary wall thickening by regulating GhIRX10 in cotton.

Upland cotton (Gossypium hirsutum) is a principal economic crop and a fundamental raw material for the textile industry. The quality of cotton fibres is significantly influenced by the synthesis of cell wall polysaccharides. This study focuses on GhIRX10, a beta-1,4-xylosyltransferase crucial for xylan backbone synthesis.

Bisabolane Sesquiterpenes with Anti-Chlamydial Activity Isolated from .

are obligate intracellular bacterial pathogens affecting humans and animals, causing miscarriage, stillbirth, or weak fetuses in the late stages of pregnancy of goats and sheep. Because there is no commercial vaccine for chlamydia in animals, drug treatment has become the most effective curative method. Natural products, also known as secondary metabolites, are becoming one of the main sources used in new drug development because of their structural diversity and biodiversity.

In vivo three-photon fluorescence imaging of mouse brain vasculature labeled by Evans blue excited at the NIR-III window.

Multiphoton fluorescence microscopy (MFM), renowned for its noninvasiveness and high spatiotemporal resolution, is extensively applied in brain structure imaging in vivo. Three-photon fluorescence (3PF) imaging, excited at the NIR-III window, can penetrate the deepest mouse cerebrovascular. Evans blue, a substance known for its low toxicity, high water solubility, and resistance to metabolism, is frequently employed to assess blood-brain barrier (BBB) permeability.

Bisphenol A exacerbates colorectal cancer progression through enhancing ceramide synthesis.

Bisphenol A (BPA) is a typical environmental endocrine disruptor which have been broadly confirmed to be associated with malignant tumors, including colorectal cancer (CRC). Lipid metabolism reprogramming performed important biological effects in cancer progression. While the role of lipid metabolism in CRC progression upon BPA exposure remain elusive.

Metal-Free Electrochemical Allylic C-H Aerobic Oxidation.

A scalable and sustainable electrochemical protocol for allylic C-H aerobic oxidation has been developed, enabling the formation of enones without the use of stoichiometric toxic oxidants or metal catalysts and offering an environmentally benign alternative to traditional chemical oxidation techniques. The process has been successfully applied to selectively oxidize a series of natural products and drug molecules, underscoring its potential for widespread adoption in both academic and industrial contexts.

Construction of management tools for early warning of prevacuum steam sterilization failure.

Objective: The aim of this study is to develop a set of management tools for early warning of steam sterilization failure, including a failure risk checklist and a calculation model for assessing early sterilization failure risk, and to verify the early warning effectiveness of the management tools through check experiment.

Methods: This study included two stages. The first stage involved the construction of a failure risk checklist and the development of a computational formula for early sterilization failure risk by expert consultation.

Dual-signal portable microRNA biosensor based on a photothermal/visual strategy induced by cascading amplification techniques and horseradish peroxidase.

MicroRNAs (miRNAs) serve as potential biomarkers for many diseases such as cancer, neurodegenerative diseases and cardiovascular conditions. The portable and accurate detection of miRNA is of great significance for the early diagnosis, treatment optimization and prognostic evaluation of diseases. Herein, a photothermal/visual dual-mode assay for let-7a is developed utilizing oxidized 3, 3', 5, 5' - tetramethylbenzidine (oxTMB) as signal reporter.

C5a-C5aR1 axis mediates lung inflammation and fibrosis induced by single-walled carbon nanotubes via promoting neutrophils recruitment.

A mounting number of studies have been documenting strong pro-inflammatory and pro-fibrotic effects of carbon nanotube (CNT). However, the molecular mechanisms of single-walled CNT (SWCNT)-provoked lung injury remain to be elucidated. Here, we established a mice model of SWCNT-induced lung injury by intratracheal instillation and found that C5a-C5a receptor-1 (C5aR1) signaling was significantly activated along with abundant neutrophils recruitment in lungs at early phase post SWCNT administration, which were positively correlated with early lung inflammation and late pulmonary fibrosis.

Correlating Personality Traits With Acute Stress Responses in Earthquake Simulations: An HRV and RESP Analysis.

Earthquakes, as significant natural disasters, still cannot be accurately predicted today. Although current earthquake early warning systems can provide alerts several seconds in advance, acute stress responses (ASR) in emergency situations can waste these precious escape seconds. To investigate the correlation between personality and ASR, this study collected the temperament and character of all participants using the Chen Huichang-60 Temperament Scale and the DISC Personality Inventory.

Exploring new mechanisms in cancer molecular pathways and pathogenic cell transformation: PIP4K2A as a prognostic marker and therapeutic target in cutaneous malignant melanoma.

Background: Cutaneous malignant melanoma is a very aggressive and metastatic form of skin cancer, typically linked with poor outcomes. Advances in genomic analysis have underscored the crucial role of T cells in tumor immunity. Immune checkpoint inhibitors have notably transformed melanoma treatment by boosting T cell activity.

Identification of as a potential therapeutic target via a novel cuproptosis-related gene signature for the prediction of liver cancer prognosis.

Background: The prognosis for liver cancer (LC) is dismal. Researchers recently discovered cuproptosis, a novel form of controlled cell death whose expression in LC and prognosis are unclear. This study reveals a gene signature to predict LC prognosis.

Multiplatform metabolomic interlaboratory study of a whole human stool candidate reference material from omnivore and vegan donors.

Introduction: Human metabolomics has made significant strides in understanding metabolic changes and their implications for human health, with promising applications in diagnostics and treatment, particularly regarding the gut microbiome. However, progress is hampered by issues with data comparability and reproducibility across studies, limiting the translation of these discoveries into practical applications.

Objectives: This study aims to evaluate the fit-for-purpose of a suite of human stool samples as potential candidate reference materials (RMs) and assess the state of the field regarding harmonizing gut metabolomics measurements.

Identification of KLHL17 as a prognostic marker for prostate cancer based on single-cell sequencing and in vitro/in vivo experiments.

Background: Prostate cancer (PCa) is a leading cause of cancer-related mortality among men, characterized by significant heterogeneity that complicates diagnosis and treatment.

Methods And Results: To enhance our understanding of PCa, we utilized single-cell RNA sequencing (scRNA-seq) data to identify distinct malignant epithelial cell subpopulations and their molecular characteristics. By integrating scRNA-seq data with bulk RNA-seq data, we constructed a prognostic risk score model.

Ziresovir in Hospitalized Infants with Respiratory Syncytial Virus Infection.

Background: Respiratory syncytial virus (RSV) is a leading cause of severe illness in infants, with no effective treatment. Results of a phase 2 trial suggested that ziresovir may have efficacy in the treatment of infants hospitalized with RSV infection.

Methods: In a phase 3, multicenter, double-blind, randomized, placebo-controlled trial conducted in China, we enrolled participants 1 to 24 months of age who were hospitalized with RSV infection.

Effectiveness of Message Framing Interventions on Improving Health Outcomes for Individuals in Diabetes Health Education Communication: A Systematic Review.

Objectives: To identify the effects of message-framing interventions on improving health outcomes of individuals in diabetes health education communication.

Methods: Four electronic databases including Web of Science, PubMed, EMBASE, and the Cochrane Library were the search engines used. The period of literature search was from their inception until December 2023.

Amphiphilic cytokine traps remodel marrow adipose tissue for hematopoietic microenvironment amelioration.

Hematopoietic stem cell transplantation (HSCT) is extensively employed in the treatment of hematological malignancies but is markedly constrained by the paucity of hematopoietic stem/progenitor cells (HSPCs). Recent studies have found that marrow adipose tissue (MAT) acts on hematopoiesis through complicated mechanisms. Therefore, the osteo-organoids fabricated using biomaterials loaded with recombinant human bone morphogenetic protein 2 (rhBMP-2) have been used as models of MAT for our research.

A Novel Plant-Derived Biopesticide Mitigates Root Rot of by Modulating the Rhizosphere Microbiome and Root Metabolome.

root rot caused by the species complex significantly affects the yield and quality of , a valuable medicinal herb. Traditional management primarily relies on chemical fungicides, which have led to pathogen resistance, environmental hazards, and concerns regarding public health and the active components in . This study explores the efficacy of a novel plant-derived biopesticide Shi Chuang Zhi Feng Ning (T1; SCZFN), alongside wettable powder (T2) and a chemical fungicide (T3), in controlling root rot and understanding their impacts on the rhizosphere microbial community and root metabolome.