Signal Transduct Target Ther
December 2022
Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue and cell functions and significant increases in the risks of various aging-related diseases, including neurodegenerative diseases, cardiovascular diseases, metabolic diseases, musculoskeletal diseases, and immune system diseases. Although the development of modern medicine has promoted human health and greatly extended life expectancy, with the aging of society, a variety of chronic diseases have gradually become the most important causes of disability and death in elderly individuals.
View Article and Find Full Text PDFObjective: The aim was to assess the expression levels of SLC7A11 and GPX4 in relation to platinum resistance and prognosis in patients with epithelial ovarian cancer (EOC).
Design: A retrospective cohort study.
Setting: Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
This study aimed to explore whether assisted biomimetic electrostimulation (BES) therapy can improve clinical outcomes in patients with abnormal endometrial receptivity undergoing frozen-thawed embryo transfer (FET) cycles. We retrospectively collected data from 132 patients who underwent FET cycles and divided them into the BES ( = 86) and non-BES (NBES) groups ( = 46). The clinical pregnancy rate (55.
View Article and Find Full Text PDFThe development of unipolar n-type semiconducting polymers with electron mobility (µ ) over 5 cm V s remains a massive challenge in organic semiconductors. Diketopyrrolopyrrole (DPP) has proven to be a successful unit for high-performance p-type and ambipolar polymers. However, DPP's moderate electron-accepting capability leads to the shallow frontier molecular orbital (FMO) levels of the resultant polymers and hence limit the µ in unipolar n-type organic transistors.
View Article and Find Full Text PDFOxygen-containing functional groups are nearly ubiquitous in complex small molecules. The installation of multiple C-O bonds by the concurrent oxygenation of contiguous C-H bonds in a selective fashion would be highly desirable but has largely been the purview of biosynthesis. Multiple, concurrent C-H bond oxygenation reactions by synthetic means presents a challenge, particularly because of the risk of overoxidation.
View Article and Find Full Text PDFWith the development of NK cell-directed therapeutic strategies, the actual effect of NK cells on the cellular SIV DNA levels of the virus in SIV-infected macaques in vivo remains unclear. In this study, five chronically SIV-infected, treatment-naïve rhesus macaques were euthanized, and the blood, spleen, pararectal/paracolonic lymph nodes (PaLNs), and axillary lymph nodes (ALNs) were collected. The distributional, phenotypic, and functional profiles of NK cells were detected by flow cytometry.
View Article and Find Full Text PDFMedicina (Kaunas)
November 2022
: Supernumerary extraocular muscle (SEOM) is extremely rare. The purpose of this paper was to review the clinical characteristics and surgical outcomes of SEOM patients with atypical restrictive strabismus. : A retrospective review was conducted on the data from 12 SEOM cases.
View Article and Find Full Text PDFFront Plant Sci
November 2022
As a fungus with both medicinal and edible value, (F. A. Wolf) Ryvarden & Gilb.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
November 2022
Osteoporotic fractures, also known as fragility fractures, are prevalent in the elderly and bring tremendous social burdens. Poor bone quality, weak repair capacity, instability, and high failure rate of internal fixation are main characteristics of osteoporotic fractures. Osteoporotic bone defects are common and need to be repaired by appropriate materials.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2022
Nearly theoretical 100% atomic utilization (supposing each atom could serve as independent sites to play a role in catalyz) of single-atom catalysts (SACs) makes it highly promising for various applications. However, for most SACs, single-atom sites are trapped in a solid carbon matrix, which makes the inner parts hardly available for reaction. Herein, a hollow N-doped carbon confined single-atom Rh (Rh-SACs/HNCR) is developed via a coordination-template method.
View Article and Find Full Text PDFBackground: The role of CXCL8 and LSECtin in colon cancer liver metastasis and immune checkpoint inhibitors (ICIs) treatment effect were widely recognized. However, the regulatory role of CXCL8 on LSECtin is still unclear.
Methods: The expression of CXCL8 or LSECtin was analyzed by TCGA database, and verified by GES110225 and clinical samples.
Background: miR-145-5P is generally considered as a tumor suppressor at early stage of colorectal cancer, but up-regulation occurs in the progressive and later stages which is associated with metastasis, indicating miR-145-5p may play dual role in colorectal cancer (CRC). To explore the detailed mechanism of miR-145-5p in carcinogenic is of importance.
Methods: The expression pattern of miR-145-5p in CRC patients was downloaded from TCGA database, and the probable mechanism involved in the carcinogenic effect of miR-145-5p was predicted by bioinformatics analysis.
The long-term protective efficacy of neutralizing antibodies (Nabs) against Omicron subvariants after inactivated booster vaccines remains elusive. During the follow-up study, 54 healthy volunteers aged 20-31 years received inactivated CoronaVac booster vaccinations and were monitored for 221 days. The dynamic efficacy and durability of Nab against Omicron subvariants BA.
View Article and Find Full Text PDFCopper zinc tin sulfide (CuZnSnS, CZTS) is attracting interest in photovoltaic applications due to its proper band gap, low cost and low toxicity. It has been found that two phases can be fabricated, kesterite and wurtzite CZTS structures. Though kesterite CZTS is proven to be thermodynamically stable, the free energy difference between kesterite and wurtzite CZTS is rather small.
View Article and Find Full Text PDFTo explore the effect of spacer structure on the adsorption capability of organo-vermiculites (organo-Vts), a series of aza-containing gemini surfactants (5N, 7N and 8N) are applied to modify Na-vermiculite (Na-Vt). Large interlayer spacing, strong binding strength and high modifier availability are observed in organo-Vts, which endow them with superiority for the adsorption of 2-naphthol (2-NP) and bromophenol blue (BPB). The maximum adsorption capacities of 5N-Vt, 7N-Vt and 8N-Vt toward 2-NP/BPB are 142.
View Article and Find Full Text PDFObjective: To develop and optimize a machine learning prediction model for cardiovascular events during exercise evaluation in patients with coronary heart disease (CHD).
Methods: 16,645 cases of cardiopulmonary exercise testing (CPET) conducted in patients with CHD from January 2016 to September 2019 were retrospectively included. Clinical data before testing and data during exercise were collected and analyzed.
Cardiolipin (CL) is a unique, tetra-acylated diphosphatidylglycerol lipid that mainly localizes in the inner mitochondria membrane (IMM) in mammalian cells and plays a central role in regulating mitochondrial architecture and functioning. A deficiency of CL biosynthesis and remodeling perturbs mitochondrial functioning and ultrastructure. Clinical and experimental studies on human patients and animal models have also provided compelling evidence that an abnormal CL content, acyl chain composition, localization, and level of oxidation may be directly linked to multiple diseases, including cardiomyopathy, neuronal dysfunction, immune cell defects, and metabolic disorders.
View Article and Find Full Text PDFMesencephalic astrocyte-derived neurotrophic factor (MANF) is a novel evolutionarily conserved protein present in both vertebrate and invertebrate species. MANF shows distinct structural and functional properties than the traditional neurotrophic factors (NTF). MANF is composed of an N-terminal saposin-like lipid-binding domain and a C-terminal SAF-A/B, Acinus and PIAS (SAP) domain connected by a short linker.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
October 2022
Androgen receptor (AR) signaling is crucial for driving prostate cancer (PCa), the most diagnosed and the second leading cause of death in male patients with cancer in the United States. Androgen deprivation therapy is initially effective in most instances of AR-positive advanced or metastatic PCa. However, patients inevitably develop lethal castration-resistant PCa (CRPC), which is also resistant to the next-generation AR signaling inhibitors.
View Article and Find Full Text PDFIn this paper, an optical fiber sensor is realized with multi-parameter measurement, including magnetic field, temperature and displacement. Then, the implementation of the three-parameter independent measurement was performed. Among of them, one of fiber Bragg gratings (FBG) is coated giant magnetostrictive particle composite (GMPC) to measure the magnetic field, another FBG is used to measure displacement, and a micro-nano fiber structure of single mode fiber (SMF)-tapering seven core fiber (T-MCF-7)-SMF (S-TM7-S) is applied to measure temperature.
View Article and Find Full Text PDFBackground: Colorectal cancer (CRC) is one of the most common digestive system tumors worldwide. Hypoxia and immunity are closely related in CRC; however, the role of hypoxia-immune-related lncRNAs in CRC prognosis is unknown.
Methods: Data used in the current study were sourced from the Gene Expression Omnibus and The Cancer Genome Atlas (TCGA) databases.
Objectives: To investigate the function and regulatory mechanisms of delphinidin in the treatment of hepatocellular carcinoma.
Methods: HepG2 and HuH-7 cells were treated with different concentrations of delphinidin. Cell viability was analysed by 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.
In recent years, deep-learning-based motor imagery (MI) electroencephalography (EEG) decoding methods have shown great potential in the field of the brain-computer interface (BCI). The existing literature is relatively mature in decoding methods for two classes of MI tasks. However, with the increase in MI task classes, decoding studies for four classes of MI tasks need to be further explored.
View Article and Find Full Text PDFAdjusting the local coordination environment of single-atom electrocatalysts is a viable way to improve catalytic performance. The diversity of coordination geometric structures is limited to the traditional in-plane configuration, with only a little consideration paid to out-of-plane configurations due to the lack of suitable carriers and fabrication methods. This study reports out-of-plane coordination of Co-based single-atom catalysts mediated by the conjugated bipyridine-rich covalent organic framework (COF).
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