Unveiling the potential of biomechanics in pioneering innovative strategies for cancer therapy.

Mechanical force transmission is pivotal in tumor biology, profoundly affecting cancer cell behaviors such as proliferation, metastasis, and resistance to therapy. To explore novel biomechanical-based therapeutic strategies for cancer treatment, this paper deciphers the advances in biomechanical measurement approaches and the impact of biomechanical signals on fundamental oncological processes such as tumor microenvironment remodeling, angiogenesis, metastasis, and drug resistance. Then, the mechanisms of biomechanical signal transduction of tumor cells are demonstrated to identify novel targets for tumor therapy.

Enhancing diagnosis prediction with adaptive disease representation learning.

Diagnosis prediction predicts which diseases a patient is most likely to suffer from in the future based on their historical electronic health records. The time series model can better capture the temporal progression relationship of patient diseases, but ignores the semantic correlation between all diseases; in fact, multiple diseases that are often diagnosed at the same time reflect hidden patterns that are conducive to diagnosis, so predefined global disease co-occurrence graph can help the model understand disease relationships. But it may contain a lot of noise and ignore the semantic adaptation of the disease under the diagnosis target.

A dual gene-activated dermal scaffolds loaded with nanocomposite particles expressing of VEGF and aFGF: Promoting wound healing by early vascularization.

The urgent need to enhance the early vascularization of dermal substitutes to improve their repair efficiency in skin defect wound presents a significant challenge. This study investigated the impact of dual gene-activated scaffolds (DGAS-M), which combined nanocomposite particles (NPs) encapsulating plasmid DNA (pDNA) of VEGF and aFGF, with the aim of enhancing early vascularization and vascular maturation. In this study, we used the liposomes to encapsulate pDNA and loaded on PLGA knitted mesh-reinforced collagen/chitosan scaffolds (PLGAm/CCS) to prepare DGAS-M.

Effect of food loop and duodenal stump fixation on clinical outcomes in patients undergoing radical gastrectomy with Roux-en-Y reconstruction for distal gastric cancer: a single-center propensity score matching analysis.

Objective: This study aimed to evaluate the safety and reliability of an innovative technique-fixation of the food loop and duodenal stump-by investigating its impact on postoperative complications and overall survival (OS) in patients undergoing distal gastrectomy with Roux-en-Y reconstruction.

Methods: A retrospective analysis was conducted on patients who underwent radical distal gastrectomy and Roux-en-Y reconstruction at Suzhou Ninth People's Hospital between January 2012 and December 2023. Patients were divided into with duodenum fixation and without duodenum fixation groups based on whether food loop and duodenal stump fixation was performed during surgery.

Boundary-Enhanced -Net for Simultaneous Four-Chamber Segmentation in Transthoracic Echocardiography.

The heart, responsible for circulating blood throughout our body, contains four chambers. Existing analysis methods primarily focus on one single ventricle. Transthoracic echocardiography provides real-time estimations of cardiac function and enables comprehensive observations of the entire heart, especially through the apical 4-chamber view.

Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus.

Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus (T2DM), which is characterized by suppressed osteoblast function and disrupted bone microarchitecture. In this study, we utilized male C57BL/6 J mice to investigate the role of SIRT3 in T2DM. Decreased SIRT3 expression and impaired mitochondrial quality control mechanism are observed in both in vitro and in vivo models of T2DM.

Design, synthesis and biological evaluation of pyrrolopyrimidine urea derivatives as novel KRAS inhibitors for the treatment of cancer.

The KRAS mutation, which occurs in approximately 14 % of lung adenocarcinomas, has recently become a crucial target for therapy via small molecules that covalently bind to the mutated cysteine. In this study, a novel series of pyrrolopyrimidine derivatives was rationally designed and synthesized, employing a structure-based drug design strategy. Through structure-activity relationship (SAR) analysis, compound SK-17 emerged as a direct and highly potent inhibitor of KRAS.

Supplementary Hesperidin Alleviated CPT-11-Induced Diarrhea by Modulating Gut Microbiota and Inhibiting the IL-17 Signaling Pathway.

Irinotecan (CPT-11) is a chemotherapy agent commonly used for the treatment of gastrointestinal tumors, with diarrhea being a frequent adverse effect. Hesperidin is a flavonoid abundant in citrus fruits and has shown potential in managing CPT-11-induced diarrhea (CID). However, the mechanisms underlying its effects remain unclear.

Anion Adsorption at the Inner-Helmholtz Plane Directs Cathode Electrolyte Interphase Formation.

Constructing a stable cathode-electrolyte-interphase (CEI) on cathode surface constitutes the foundation of realizing high-voltage Li-ion batteries, yet its formation, a highly heterogeneous process involving irreversible reactions between electrolyte components and cathode materials, remains poorly understood. Herein, combining multiple in situ/operando interfacial characterization techniques, we establish the correlation between interfacial structure and interphasial chemistry, and reveal the key role played by adsorptive behavior of various electrolyte components in the inner-Helmholtz plane during CEI formation. Quartz crystal microbalance equipped with dissipation modification detects that difluorooxalatoborate (DFOB) anion preferentially adsorbed on LiCoO tends to expel carbonate solvents from the adsorption layer, thus suppressing their electrochemical decomposition at high voltages and leading to a more compact CEI derived from anions with limited contribution from organic ingredients.

Composite Engineering Facilitates High-Performance CuSe-GeTe Thermoelectrics.

CuSe has emerged as a promising thermoelectric material due to its low lattice thermal conductivity, high Seebeck coefficient, and high peak figure of merit () at elevated temperatures. However, its performance is limited by a high intrinsic carrier concentration and low carrier mobility. In this work, we investigate CuSe-based composites to overcome these challenges by introducing GeTe as compound phase to optimize carrier concentration, enhance mobility, and promote phonon scattering.

Development and functional validation of a disulfidoptosis-related gene prognostic model for lung adenocarcinoma based on bioinformatics and experimental validation.

Background: Disulfidoptosis is increasingly linked to cancer progression, yet its immunological impacts and prognostic value in lung adenocarcinoma (LUAD) remain poorly understood. This study aims to delineate the predictive significance of disulfidoptosis-related genes (DRGs) in LUAD, their potential as therapeutic targets, and their interaction with the tumor microenvironment.

Methods: We analyzed the expression profiles of 23 DRGs and survival data, performing consensus clustering to identify molecular subtypes.

Characteristic Thinning of Temporal Parafoveal Retinal Thickness in Patients With Intermittent Exotropia.

Purpose: To quantitatively compare the temporal parafoveal retinal thickness between intermittent exotropia (IXT) and healthy controls using optical coherence tomography, exploring the relationship between retinal structural changes and retinal correspondence.

Design: Cross-sectional study.

Methods: Twenty basic type IXT with an exodeviation angle of 35 prism diopters (PD) were compared with 20 age-matched healthy controls.

Botulinum Toxin Injection With Reduced Volume in the Absence of Electromyographic Assistance for Acute Acquired Comitant Esotropia of 25 Prism Diopters or Less.

Purpose: To evaluate the effectiveness and safety of botulinum toxin type A (BTXA) injection with reduced volume without electromyographic guidance for the treatment of acute acquired comitant esotropia (AACE) of 25 prism diopters (PD) or less.

Methods: The authors reviewed the medical records of 60 patients with AACE of 25 PD or less, including 40 patients treated with BTXA injections (BTXA group) and 20 patients treated with Fresnel prism (Fresnel prism group). Patients in the BTXA group were injected with 5 to 6.

Making stereopsis related to the ability of ocular deviation: a new paradigm for assessment of intermittent exotropia.

Aim: To investigate the underlying factors by establishing a new paradigm for assessing control ability under stereopsis testing conditions.

Methods: This was a prospective observational study. We evaluated the control ability of intermittent exotropia (IXT) patients in three conditions: natural 2D optotype viewing, 2D optotype viewing with polarized glasses, and 3D optotype viewing with polarized glasses.

CircMETTL6 Suppresses Ovarian Cancer Cell Growth and Metastasis Through Inhibition of GDF15 Transcription by Disrupting the NONO-POLR2A Complex.

Circular RNAs (circRNAs) are a distinctive class of non-coding RNAs with covalent closed-loop structure, lacking 5' caps and 3' poly(A) tails. These molecules are prevalent in eukaryotes and play key roles in cancer. Here, the function of a new circRNA, circMETTL6, in ovarian cancer is identified and investigated.

Horizontal rectus muscle insertion sites in patients with infantile esotropia and acute acquired concomitant esotropia.

Purpose: To investigate the characteristics of horizontal rectus muscle insertion sites in patients with infantile esotropia (IE) and acute acquired concomitant esotropia (AACE).

Methods: The medical records of 166 IE patients and 261 AACE patients who underwent horizontal rectus muscle surgeries were reviewed retrospectively, including age at surgery, spherical equivalent (SE), and angle of esodeviation at near and distance. The limbus-insertion distances (LID) and widths of the medial rectus (MR) and lateral rectus (LR) muscles were measured intraoperatively using a caliper.

Zhuyu pill attenuates metabolic-associated fatty liver disease by regulating macrophage polarization through TLR4 signaling pathway.

Background: Metabolic-associated fatty liver disease (MAFLD) is the leading chronic liver disease globally, impacting a large segment of the population. The Zhuyu Pill (ZYP), a traditional Chinese remedy, has been clinically used for treating MAFLD, with its effectiveness demonstrated in both human patients and animal models. However, the underlying mechanisms of how ZYP addresses MAFLD still require further investigation.

Enhancing noise suppression of phase estimation in continuous-variable quantum key distribution with discrete modulation.

Accurately estimating phase is crucial in continuous-variable quantum key distribution systems, directly impacting the final secret key rate. In previous systems that utilize the local local oscillator, phase estimation is closely tied to the amplitude and signal-to-noise ratio (SNR) of the pilot signal. As SNR decreases, so does the accuracy of phase estimation, leading to increased excess noise and a potential loss of the system's secret key rate.

Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis.

mTOR plays a pivotal role in cancer growth control upon amino acid response. Recently, CDK inhibitor P27KIP1 has been reported as a noncanonical inhibitor of mTOR signaling in MEFs, via unclear mechanisms. Here, we find that P27KIP1 degradation via E3 ligase TRIM21 is inhibited by human micropeptide hSPAR through its C-terminus (hSPAR-C), causing P27KIP1's cytoplasmic accumulation in breast cancer cells.

Epigenetic Modifications in HBV-Related Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Hepatitis B virus (HBV) is the main pathogen for HCC development. HBV covalently closed circular DNA (cccDNA) forms extra-host chromatin-like minichromosomes in the nucleus of hepatocytes with host histones, non-histones, HBV X protein (HBx) and HBV core protein (HBc).

Global, regional, and national burden of young COPD, 1990-2021, with forecasts to 2050: a systematic analysis for the global burden of disease study 2021.

Background: Young chronic obstructive pulmonary disease (COPD) refers to people with COPD between the ages of 20 and 50 years. Current epidemiological studies focus on local geography, and there is a lack of global-level analysis. This study provides in-depth analyses of the disease burden of young COPD at global, regional, and national levels.

Energy Aggregation for Illuminating Upconversion Multicolor Emission Based on Ho Ions.

Lanthanide-doped upconversion luminescent nanoparticles (UCNPs) have garnered extensive attention due to their notable anti-Stokes shifts and superior photostability. Notably, Ho-based UCNPs present a complex energy level configuration, which poses challenges in augmenting their luminescence efficiency. Herein, a rational design strategy was used to enhance the upconversion luminescence intensity of Ho ions by improving the photon absorption ability and energy utilization efficiency.

A Powerful Organic Photosensitizer for Effective Treatment of Malignant Tumors Via Activating Antitumor Immunity.

Photodynamic therapy (PDT) has emerged as an innovative approach in cancer treatment, effectively inducing tumor cell death through light-triggered reactive oxygen species (ROS) generation. Additionally, PDT can also trigger antitumor immune responses, thereby reducing the risk of postoperative tumor recurrence. However, the development of highly efficient photosensitizers aimed at activating immune responses for comprehensive tumor eradication remains at an early stage.