Publications by authors named "Shen Shuijuan"

We reported a rare case of peritoneal dialysis-associated peritonitis caused by Weissella confusa. In this case, the symptoms of peritonitis were insidious and atypical, with only turbid peritoneal dialysis effluent and no fever or abdominal pain. The peritoneal dialysis effluent showed slightly elevated leukocytes (predominantly lymphocytes).

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Background: There is still a very high morbidity and mortality rate for patients undergoing peritoneal dialysis (PD). The advanced lung cancer inflammation index (ALI) has been demonstrated to be associated with the prognosis in multiple types of cancers. Like in cancer, systemic chronic low-grade inflammation is one of the distinguishing features of PD patients.

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Article Synopsis
  • This study explores how ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) affects vascular calcification in rats, focusing on its ability to regulate the calcification process.
  • By inducing vascular smooth muscle cell (VSMC) calcification and then overexpressing ENPP1, researchers observed a significant reduction in calcium and phosphorus levels in the aorta.
  • Results suggest that ENPP1 enhances pyrophosphate (PPi) levels and prevents VSMC transformation that leads to calcification, highlighting its potential as a therapeutic target for vascular calcification disorders.*
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Background: Cardiovascular disease (CVD) is an important cause of morbidity and mortality in peritoneal dialysis (PD) patients. Cardiovascular calcification (CVC) is highly prevalent in PD patients and could predict their cardiovascular mortality. Soluble urokinase plasminogen activator receptor (suPAR) is closely associated with coronary artery calcification in hemodialysis patients and is an important predictor of CVD.

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Introduction: Sarcopenia is associated with significant cardiovascular risk, and death in patients undergoing peritoneal dialysis (PD). Three tools are used for diagnosing sarcopenia. The evaluation of muscle mass requires dual energy X-ray absorptiometry (DXA) or computed tomography (CT), which is labor-intensive and relatively expensive.

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Background: Sarcopenia is associated with significant morbidity and mortality in patients undergoing peritoneal dialysis (PD). Three different tools must be applied to measure the three indices for diagnosing sarcopenia. Considering the cumbersome diagnostic steps and multi-layered mechanisms underlying sarcopenia, we combined new biomarker with bioelectrical impedance analysis (BIA) data to predict PD sarcopenia.

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Introduction: The peritoneal dialysis catheter (PDC) can be placed either through the laparoscopic technique, percutaneous technique, or surgical procedures. The utilization of these PDC placement procedures is based on the successful placement and reduced risk of development of complications. The main objective of this study was to compare the complications associated with the laparoscopic technique to those linked to open surgery during PDC placement.

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Background: Cardiovascular events (CVE) are the leading cause of death in peritoneal dialysis (PD) patients. The predictive value of cardiac valve calcification (CVC) for CVE in dialysis patients remains controversial. In particular, such studies are limited in PD patients.

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Article Synopsis
  • The study aimed to create a sensitive test called Kim-1-TRFIA to measure kidney injury molecule-1 (Kim-1) levels, which can help diagnose acute kidney injury (AKI).
  • The method involved using a double-antibody sandwich technique to evaluate Kim-1 concentration in the serum of both healthy individuals and AKI patients, showing significant differences between the two groups.
  • Results indicated that the new test is reliable, with good sensitivity and specificity, and can also help assess the severity of AKI based on Kim-1 levels in the serum.
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The peritoneal dialysis catheter (PDC) can be placed either through the laparoscopic technique, percutaneous technique or surgical procedures. The utilization of these PDC placement procedures is based on successful placement and reduced risk of development of complications. The main objective of this study was to compare the complications associated with laparoscopic vs.

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Objective: To investigate the correlation between serum ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) level and severity of abdominal vascular calcification in end-stage renal disease (ESRD) patients receiving dialysis.

Methods: A total of 124 patients were consecutively enrolled into the study in our local institution. Based on the Kidney Disease Improving Global Outcomes (KDIGO) guidelines and recommendations, abdomen lateral X-ray was used to determine abdominal aortic calcification score (AACS) for each patient at enrollment.

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Podocytes play important roles in the progression of diabetic kidney disease (DKD) and these roles are closely associated with cytoskeletal actin dynamics. N-Methyl-d-aspartate receptors (NMDARs), which consist of two functional NR1 subunits and two regulatory NR2 subunits, are widely expressed in the brain but are also found in podocytes. Here, we found increased NR1 expression in two diabetic mouse models and in podocytes incubated in high glucose (HG).

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Aim: Early intervention in patients with chronic kidney disease (CKD) significantly improves the prognosis. The present widely used markers of renal function, such as serum creatinine (sCr), fail to reflect early renal damage and predict the progression of disease. The authors aimed to evaluate whether neutrophil gelatinase-associated lipocalin (NGAL), a novel specific biomarker of acute kidney injury, could predict the progression of CKD.

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