miRNA-211-5p inhibition enhances the protective effect of hucMSC-derived exosome in Aβ -induced SH-SY5Y cells by increasing NEP expression.

Exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs) could alleviate Alzheimer's disease (AD) defects. Additionally, engineered exosomes are more effective in treating diseases. In this study, we established an in vitro model of AD by treating SH-SY5Y cells with Aβ .

Sugammadex for reversing neuromuscular blockages after lung surgery: A systematic review and meta-analysis.

Background: This study determined whether sugammadex was associated with a lower risk of postoperative pulmonary complications and improved outcomes in lung surgeries.

Methods: A systematic literature search was conducted using PubMed, Embase, Web of Science, and the Cochrane Library from January 2000 to March 2022. The characteristics of lung surgeries using sugammadex treatment compared with control drugs and postoperative outcomes were retrieved.

Does surgical plethysmographic index-guided analgesia affect opioid requirement and extubation time? A systematic review and meta-analysis.

Purpose: This meta-analysis of all relevant clinical trials investigated surgical plethysmographic index (SPI)-guided analgesia's efficacy under general anesthesia for perioperative opioid requirement and emergence time after anesthesia.

Methods: PubMed, Embase, Web of Science, and Cochrane Library were searched up to January 2022 to identify clinical trials comparing SPI-guided and conventional clinical practice for patients who underwent general anesthesia. With the random-effects model, we compared intraoperative opioid consumption, emergence time, postoperative pain, analgesia requirement, and incidence of postoperative nausea and vomiting (PONV).

Music Intervention for Pain Control in the Pediatric Population: A Systematic Review and Meta-Analysis.

Music intervention (MI) has been applied as an effective adjunctive treatment for pain control in various clinical settings. However, no meta-analysis has yet been published on the analgesic effects of MI in infants and children. We performed a systematic review of PubMed, EMBASE, Web of Science, and Cochrane Library databases to identify randomized controlled trials (RCTs) with the keywords "pain" AND "music therapy" from inception to January 2022.

The Effect of Telehealth Services on Provider Productivity.

Background: Telehealth services historically have played a small role in the provision of health care in the United States. However during the coronavirus disease 2019 (COVID-19) pandemic, public and private insurers rapidly expanded access to telehealth in order to reduce exposure and avoid transmission. It is unknown whether telehealth will become a more regular substitute for in-person care beyond the pandemic.

[Expression of follicular helper T cells in peripheral blood of patients with hepatic echinococcosis].

Objective: To detect the expression of follicuLar helper T cells (Tfh) and interleukin-21 (IL-21) in the peripheral blood of patients with hepatic echinococcosis and healthy controls, so as to explore the associations of Tfh and IL-21 expression with the progression of hepatic echinococcosis.

Methods: Fifty cases of hepatic echinococcosis and healthy controls were collected from Qinghai Provincial People's Hospital, respectively. Flow cytometry was used to detect the expression of Tfh cells in the peripheral blood of hepatic echinococcosis patients and healthy controls, and enzyme-linked immunosorbent assay (ELISA) was used to detect serum IL-21 expression in hepatic echinococcosis patients and healthy controls.

Herpes zoster correlates with pyogenic liver abscesses in Taiwan.

Objective: The purpose of the paper was to explore the relationship between herpes zoster and pyogenic liver abscesses in Taiwan.

Methods: This was a nationwide cohort study. Using the database of the Taiwan National Health Insurance Program, there were 33049 subjects aged 20-84 years who were newly diagnosed with herpes zoster from 1998 to 2010 that were selected for our study, and they were our herpes zoster group.

Epidural cyst with cauda equina syndrome after epidural anesthesia.

A 40-year-old woman without remarkable medical history received epidural anesthesia for uterine cervix conization. Six hours after the operation, cauda equina syndrome occurred. Magnetic resonance imaging of the spine revealed epidural fluid accumulation around L5, as well as L4/5 herniated intervertebral disc found incidentally.

Evidence of increased DNA content of murine thymocytes caused by cocaine.

C57BL mice were injected intraperitoneally daily with 10 to 50 mg/kg of cocaine for five days. Four hours after the last injection, the thymuses were removed, and the effects on DNA and protein content of the surviving cells were measured. A dose-dependent increase in DNA content per cell, determined by UV spectrophotometric analysis, and a dose-dependent increase in protein content per cell, as measured using the Bio-Rad reagent, were observed.