Publications by authors named "Shen Lu"
Article Synopsis
- - Glucosylceramidase beta 1 (GBA1) mutations increase the risk of Parkinson's disease (PD), but many carriers don't develop symptoms; this study explores factors that may influence PD development in GBA1 carriers.
- - The research used a database with participants divided into non-manifesting GBA1 carriers, controls, and those with GBA1-associated PD, analyzing exposure to pesticides, smoking, and other factors in relation to PD risk and symptoms.
- - Findings indicated that pesticide exposure was linked to a higher risk of PD in GBA1 carriers, while smoking seemed to lower that risk; however, early-stage GBA1-associated PD had more severe symptoms than non-manifesting carriers,
Schizophrenia (SCZ) is a severe mental disorder affecting around 1% of individuals worldwide. The variability in response to antipsychotic drugs (APDs) among SCZ patients presents a significant challenge for clinicians in determining the most effective medication. In this study, we investigated the biological markers and established a predictive model for APD response based on a large-scale genome-wide association study using 3269 Chinese schizophrenia patients.
View Article and Find Full Text PDF() is a gram-negative, spiral-shaped bacterium that colonizes the human stomach, leading to various gastric diseases. The efficacy of traditional treatments, such as bismuth-based triple and quadruple therapies, has been reduced due to increasing antibiotic resistance and drug toxicity. As a result, the development of effective vaccines was proposed to control -induced infections; however, one of the primary challenges is the lack of potent adjuvants.
View Article and Find Full Text PDFEffects of Frontal-Midline Theta Neurofeedback with Different Training Directions on Goal-Directed Attentional Control.
Appl Psychophysiol Biofeedback
November 2024
As a significant component of executive function, goal-directed attentional control is crucial for cognitive processing and is closely linked to frontal-midline theta (FMT) rhythms. However, how up-regulation and down-regulation of FMT through neurofeedback training (NFT) impact goal-directed attention control remains unclear, especially for both short-term and long-lasting effects. Therefore, this study employed a single-blind sham-controlled between-subject design to answer this question.
View Article and Find Full Text PDFFamilial adult-onset neuronal intranuclear inclusion disease: A case report and literature review.
Medicine (Baltimore)
November 2024
Rationale: Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder with highly variable clinical manifestations, making diagnosis challenging. Recent advancements in genetic and pathological testing, such as the identification of GGC repeat expansions in the NOTCH2NLC gene, have improved diagnostic accuracy, but familial cases remain underreported.
Patient Concerns: This report details 3 cases of familial adult-onset NIID in 2 sisters and 1 brother.
Article Synopsis
- * Key influences on PCC competency included high empathy, low job burnout, humanistic nursing training, and strong personnel agency, contributing to 59.2% of the variance.
- * Recommendations include enhancing empathy, reducing burnout, providing more humanities training, and developing interpersonal skills to improve nurses' PCC capabilities.
Here, a combination of dopamine self-polymerization and epoxy modified SiO (M-SiO) grafting was proposed, with the purpose of increasing interfacial adhesion of UHMWPE fiber. Inspired by mussel adhesion, polydopamine (PDA) was deposited onto the surface of UHMWPE fiber to form a thin layer with amino and hydroxyl groups. M-SiO nanoparticles were then adhered to fiber surface via chemical reactions by a "two-step" or "one-step" technology.
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- The study examines the link between Myocardial Infarction (MI) and severe mental disorders (SMDs), highlighting the unclear genetic factors contributing to their shared risks and potential mortality.
- A combined genome-wide association study (GWAS) and exome-wide association study (EWAS) identified common genetic elements and pathways connecting MI and SMDs, leading to the discovery of 27 potential causal genes.
- The findings suggest that understanding the genetic overlap may deepen insights into the mechanisms behind both conditions and inform future treatments.
Article Synopsis
- The study investigates how to manage prolonged pleural air leaks after lung surgery by comparing conservative treatment to chest tube placement.
- It involved a review of 84 patients, with a focus on recovery metrics like hospital stay duration and pain levels.
- Results show that chest tube placement leads to shorter hospital stays and faster tube removal, although patients experienced slightly more pain with this method, indicating it may be beneficial for select patients.
Article Synopsis
- Continuous monitoring of drug molecules in living organisms can transform healthcare with tailored pharmacokinetic insights.
- Researchers developed an innovative in vivo photoelectrochemical biosensor using single Cu atoms for efficient detection of tetracycline molecules in mice.
- This biosensor shows potential for personalized medicine by providing real-time data, but findings are only validated for male mice, necessitating further research for broader applications.
Article Synopsis
- - Alzheimer’s disease (AD) leads to significant loss of specific types of neurons in the brain, particularly glutamatergic and cholinergic neurons, which are linked to cognitive decline in patients.
- - The study developed systems to differentiate patient-derived iPSCs into basal forebrain cholinergic neurons (BFCNs) to investigate their response to Aβ oligomers, finding that BFCNs secreted less Aβ peptide and were less sensitive to certain toxic effects compared to cortical neurons.
- - Distinct electrophysiological responses and neuropathological changes were observed between AD-BFCNs and cortical glutamatergic neurons, suggesting that different neuron types react differently to the pathological environment of AD, aiding in
Article Synopsis
- Photosynthetic organisms like cyanobacteria adjust their carbohydrate metabolism based on light conditions, switching between making and breaking down carbohydrates.
- A study on the cyanobacterium Synechocystis sp. PCC 6803 revealed two iso-enzymes of phosphofructokinase (PFK) that uniquely use ADP instead of ATP and have different regulatory mechanisms affecting their activity in light and darkness.
- This finding is significant as it shows a previously undocumented ADP dependence in the PFK-A enzyme family, suggesting a unique evolutionary adaptation in some cyanobacteria and a few related bacteria.
Background: Cancer-related fatigue (CRF) is a prevalent adverse effect experienced by cancer patients while receiving and after treatment, impacting as many as 90% of individuals. Although CRF is common, the genetic processes responsible for it and their influence on individual vulnerability are not well understood and are still being investigated.
Objective: The primary objective of this scoping review is to identify and assess genes linked to the vulnerability and severity of CRF.
Article Synopsis
- The study examines the relationship between thyroid hormone sensitivity, measured by the fT3/fT4 ratio, and the prognosis in individuals with metabolic syndrome (MetS).
- Data from the National Health and Nutrition Examination Survey (NHANES) (2007-2012) was analyzed, revealing that higher levels of free thyroxine (fT4) were linked to increased mortality risks, while higher free triiodothyronine (fT3) and the fT3/fT4 ratio had protective effects.
- The findings indicate that greater thyroid sensitivity, as reflected by the fT3/fT4 ratio, may lead to lower mortality risks in adults with MetS, highlighting its potential
Article Synopsis
- Individuals with schizophrenia (SCZ) show altered sleep patterns, particularly in NREM sleep, with group-level differences seen in EEG metrics like spindles and slow oscillations compared to controls.
- A study involving 103 SCZ patients and 68 controls confirmed these differences and revealed significant variability in sleep metrics among SCZ patients, suggesting individual differences beyond clinical factors are present.
- The research indicated that medication regimens, especially olanzapine, significantly contribute to this variability and highlighted exaggerated age-related effects on certain sleep metrics in SCZ patients, raising concerns about biological aging and potential medication side effects.
Article Synopsis
- Frontotemporal dementia (FTD) is a complex disorder with various genetic and clinical expressions, and this study focused on a large cohort from China to better understand its characteristics.
- Out of 248 patients studied, nearly 20% had identifiable genetic mutations, with the C9orf72 dynamic mutation being the most common.
- Elevated levels of certain plasma biomarkers (GFAP, α-syn, NfL, and p-tau181) were found in FTD patients, indicating their potential for improving diagnostic accuracy.
Article Synopsis
- The study evaluated the safety and effectiveness of administering the inactivated quadrivalent influenza vaccine (IIV4) and the 23-valent pneumococcal polysaccharide vaccine (PPSV23) together in adults aged 60 and older in China.
- Participants were split into two groups: one received both vaccines at the same time (C group) and the other received them separately (S group). Blood samples were tested for antibody levels after vaccination.
- Results showed that the immune response from the combined administration was comparable to the separate administration, with fewer adverse events reported in the C group, indicating that it is a safe option for older adults.
Article Synopsis
- Coxsackievirus group B3 (CVB3) is a major cause of viral myocarditis (VMC), and current treatments are lacking; this study reveals how CVB3 inhibits a key enzyme, argininosuccinate synthase 1 (ASS1), impacting the immune response and inflammation in the heart.* -
- The research demonstrates that CVB3 not only manipulates metabolic pathways by consuming citrulline to enhance ASS1 but also actively promotes inflammatory responses through macrophage activation, contributing to VMC progression.* -
- Supplementing with citrulline can counteract these effects by reducing ASS1 levels, improving macrophage polarization, and reducing the harmful impacts of CVB3,
Article Synopsis
- The study investigates the association between the TERT rs10069690 genetic variant and cancer risk, highlighting that telomerase activation is important in cancer development.
- A meta-analysis of 55 studies with over 334,000 cancer patients and 741,000 controls found a significant link between this variant and an increased risk of multiple cancer types, particularly in European and Asian groups.
- The findings suggest rs10069690 is a risk factor for solid tumors, including breast, ovarian, and gastric cancers, but showed a decreased risk for some other cancer types like hepatocellular carcinoma and prostate cancer.
Against the backdrop of escalating environmental pollution and resource depletion induced by traditional agricultural industry development, the imperative for agricultural efficiency and ecologically friendly practices has become pivotal for global agricultural sustainability. In the digital era, rural digitalization has substantially amplified agricultural production efficiency while notably reducing environmental pollution. This study is based on panel data from 1602 counties in China spanning from 2011 to 2020, measuring the levels of rural digitalization and agricultural green total factor productivity (AGTFP) across these counties, empirically examining their dynamic correlation.
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- A study aimed to understand the survival rates of female breast cancer patients with liver metastasis, specifically those classified as T1-2N0-1, and to create a tool for predicting their prognosis.
- The research analyzed data from 1,923 patients, identifying important factors like age, marital status, and specific biomarkers (ER, PR, HER2) that affect survival rates.
- A nomogram was developed based on these factors, showing a good prediction accuracy compared to standard AJCC staging, with a significant difference in outcomes between low-risk and high-risk patients.
Based on favorable outcomes and decreased propensity for lymph node and distant metastasis, multiple ground-glass nodules (GGNs) are now predominantly recognized as early-stage primary independent lung cancer. In this study, we discuss a case involving a patient with reoperative multifocal GGNs who was ultimately diagnosed with early multiple intrapulmonary metastases and multifocal primary lung cancers. This patient exhibited multisite epidermal growth factor receptor (EGFR) mutations, including the classical L858R, exon 19 deletion and the rare V834L variant.
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- Previous research highlights that individuals with Internet gaming disorder (IGD) have impaired inhibitory control and unique brain patterns, but the effects of excessive gaming without addiction (EUG) remain unclear.
- This study compared EUG gamers and non-gamers through EEG recordings and a Stroop task, finding no major differences in reaction time, accuracy, or P3 amplitude.
- Interestingly, EUG gamers showed quicker P3 latency and lower theta and alpha band power during resting state, suggesting they may actually have better inhibitory control and different brain activity than those with IGD.