Publications by authors named "Shen Ling"

While circular RNAs (circRNAs) exhibit lower abundance compared to corresponding linear RNAs, they demonstrate potent biological functions. Nevertheless, challenges arise from the low concentration and distinctive structural features of circRNAs, rendering existing methods operationally intricate and less sensitive. Here, we engineer an intelligent tetrahedral DNA framework (TDF) possessing precise spatial pattern-recognition properties with exceptional sensing speed and sensitivity for circRNAs.

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Epitranscriptomic chemical modifications of RNAs have emerged as potent regulatory mechanisms in the plant stress adaptation process. Currently, over 170 distinct chemical modifications have been identified in mRNAs, tRNAs, rRNAs, microRNAs (miRNAs), and long-noncoding RNAs (lncRNAs). The genetic and molecular studies have identified the genes responsible for adding and removing chemical modifications on RNA molecules, known as "writers" and "erasers," respectively.

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The design of a protective electron-rich surface is an ideal route to enhance the performance of catalysts. Due to the higher work function of NiB, facile-directed electron transport occurs from PtNi to NiB to enrich electron density on the surface of the NiB shell. This process increases hydrogen adsorption-desorption kinetics and mitigates Cl corrosion.

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Metabolic dysfunction is one of the key pathological events after ischemic stroke. Disruption of cerebral blood flow impairs oxygen and energy substrate delivery, leading to mitochondrial oxidative phosphorylation dysfunction and cellular bioenergetic stress. Investigating the effects of circSCMH1, a brain repair-related circular RNA, on metabolism may identify novel therapeutic targets for stroke treatment.

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The accelerated deterioration of carbonate stone artifacts under climate change has long been an urgent issue. Inspired by biomineralization, we developed carboxymethyl chitosan-diammonium hydrogen phosphate (CD) composite and investigated the conservation effectiveness of the CD composite compared to diammonium hydrogen phosphate (DAP) on limestone. The morphologies and microstructures were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FT-IR).

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Ischemic stroke is a high-mortality disease that urgently requires new therapeutic strategies. Insufficient cerebral blood supply can induce poly (ADP-ribose) polymerase (PARP) activation and mitochondrial dysfunction, leading to tissue damage and motor dysfunction. We demonstrate that the expression of TCDD inducible PARP (TIPARP) is elevated in ischemic stroke patients and mice.

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Chronic postsurgical pain (CPSP), with a high prevalence and rising epidemic of opioids crisis, is typically derived from acute postoperative pain. Our knowledge on the forming of chronic pain mostly derives from mechanistic studies of pain processing in the brain and spinal cord circuits, yet most pharmacological interventions targeting CNS came to be unhelpful in preventing CPSP. Revealing the peripheral mechanisms behind the transition from acute to chronic pain after surgery could shine a light on the novel analgesic regimens.

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Long noncoding small nucleolar RNA (LncRNA) host gene 16 (SNHG16) is associated with certain diseases, including cancers. However, its role and mechanism in () infection remain unclear. Here, we demonstrated that SNHG16 expression levels were suppressed in peripheral blood mononuclear cells (PBMCs) and CD14 monocytes of tuberculosis (TB) patients.

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Astrocytic processes minutely regulate neuronal activity via tripartite synaptic structures. The precision-tuning of the function of astrocytic processes is garnering increasing attention because of its significance in promoting brain repair following ischemic stroke. Microdomain calcium (Ca) transients in astrocytic processes are pivotal for the functional regulation of these processes.

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Article Synopsis
  • This study examines the growth and trends in the research on perioperative enteral nutrition (PEN) from 2014 to 2023, using data from the Web of Science database.! -
  • Key findings show an increase in annual publications, with the U.S. and Harvard University being the most prominent contributors, and the Journal of Parenteral and Enteral Nutrition leading in productivity.! -
  • The analysis highlights important research areas like enhanced recovery after surgery and gut microbiota, providing valuable insights for future research directions in PEN.!
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Piperacillin/tazobactam is a widely used anti-infective agent. However, prolonged use can lead to adverse drug reactions, primarily presenting as fever and various abnormal laboratory test results. Certain abnormal test outcomes may mislead clinical assessments.

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Background: Breast cancer has the highest incidence rate and causes the most fatalities among all female cancers worldwide. Triple-negative breast cancer (TNBC) is known for its strong invasiveness and higher rates of recurrence. In this research, we aimed to identify MIR4435-2HG as a promising long non-coding RNA (lncRNA) biomarker and therapeutic target for TNBC.

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Article Synopsis
  • * Researchers have developed mannose-modified mesoporous polydopamine nanosystems (Man-mPDA NPs) to target macrophages for delivering the anti-TB drug rifampicin, and to use photothermal therapy (PTT) for killing Mtb-infected macrophages.
  • * The Rif@Man-mPDA NPs not only enhance drug delivery and effective thermal treatment, but also boost the immune response in host cells, reducing Mtb loads and tissue damage in a mouse model, presenting a promising new approach for CTB treatment
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Major depressive disorder (MDD) is a prevalent mental disorder that significantly impacts social and psychological function, but no effective medication is currently available. Circular RNAs (circRNAs) have been reported to participate in the pathogenesis of MDD which are envisioned as promising therapeutic targets. However, nonviral-based delivery strategies targeting circRNA against MDD are not thoroughly investigated.

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Article Synopsis
  • Tuberculosis (TB) remains a major global health threat, and enhancing treatment effectiveness, especially against drug-resistant strains, is a significant challenge.
  • A new graphene oxide-based system (GO-PEI-MAN) has been designed to deliver antibiotics and autophagy inducers specifically to macrophages, improving the ability to kill the Mycobacterium tuberculosis bacteria.
  • This system showed promising results, as it effectively enhanced drug delivery and immune response, leading to better Mtb killing in infected macrophages and reduced bacterial levels in infected mice, without causing toxicity.
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In order to improve dispersibility, polymerization characteristics, chemical stability, and magnetic flocculation performance, magnetic FeO is often assembled with multifarious polymers to realize a functionalization process. Herein, a typical three-dimensional configuration of hyperbranched amino acid polymer (HAAP) was employed to assemble it with FeO, in which we obtained three-dimensional hyperbranched magnetic amino acid composites (FeO@HAAP). The characterization of the FeO@HAAP composites was analyzed, for instance, their size, morphology, structure, configuration, chemical composition, charged characteristics, and magnetic properties.

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Co-activation signal that induces/sustains pleiotropic effector functions of antigen-specific γδ T cells remains unknown. Here, Mycobacteria tuberculosis (Mtb) tuberculin administration during tuberculosis (TB) skin test resulted in rapid expression of co-activation signal molecules CD137 and CD107a by fast-acting Vγ2Vδ2 T cells in TB-resistant subjects (Resisters), but not patients with active TB. And, anti-CD137 agonistic antibody treatment experiments showed that CD137 signaling enabled Vγ2Vδ2 T cells to produce more effector cytokines and inhibit intracellular Mtb growth in macrophages (Mɸ).

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Article Synopsis
  • - The study focuses on developing efficient bifunctional electrocatalysts for oxygen evolution and reduction reactions in rechargeable Zn-air batteries, specifically using a CoNi@Fe─N─C catalyst.
  • - The catalyst utilizes a directional electron transfer pathway, where Co/Ni atoms bond with the Fe─N─C support, enhancing the overall catalytic performance through increased pyridinic nitrogen content.
  • - Results show that the CoNi@Fe─N─C catalyst achieves strong electrocatalytic activity, necessary for practical applications, and demonstrates durability in assembled zinc-air batteries, with performance comparable to high-end alternatives like Pt/C.
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  • * Researchers identified three key genes (McSTE24, McCYP305a1, and McJHEH) from the blister beetle Mylabris cichorii that are involved in cantharidin production, particularly during a specific developmental stage (20-25 days old).
  • * Gene expression suppression through RNA interference showed that these three genes significantly impact cantharidin biosynthesis in males, highlighting a sexual dimorphism in production, where females produce less cantharidin independently. *
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Coal spontaneous combustion (CSC) is disturbed by complex downhole conditions. However, current research by scholars mainly focuses on the impact of single conditional disturbances on CSC, which is difficult to comprehensively characterize the oxidation and spontaneous combustion characteristics of granular coal in a complex environment. For this reason, a temperature-programmed gas chromatographer (TP-GC) hyphenated instrument and a C600 high-precision microcalorimeter was used for analysis.

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Intercellular adhesion molecule 1 (ICAM1) is a cell surface adhesion glycoprotein in the immunoglobulin supergene family. It is associated with several epithelial tumorigenesis processes, as well as with inflammation. However, the function of ICAM1 in the prognosis of tumor immunity is still unclear.

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Heterologous expression of an terpenoid gene cluster derived from Gö66 in J1074 led to the discovery of three novel labdane diterpenoids featuring an unprecedented 6/6/5-fused tricyclic skeleton, designated as atralabdans A-C (-), along with a known compound, labdanmycin A. Compounds - were identified through extensive spectroscopic analysis, including NMR calculations with DP4+ probability analysis, and a comparative assessment of experimental and theoretical electronic circular dichroism (ECD) spectra. A plausible biosynthetic pathway for these compounds was proposed.

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Introduction: Postoperative ileus (POI) is a postoperative complication that can cause lingering recovery after colorectal resection and a heavy healthcare system burden. Acupuncture aims to prevent postoperative complications, reduce the duration of POI, help recovery and shorten hospital stays. We hypothesise that preoperative electroacupuncture (EA) can promote POI recovery under the enhanced recovery after surgery protocol after laparoscopic surgery in patients with POI.

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Designing electrocatalysts for seawater splitting remains challenging. A Ru-Co alloy supported by an N-doped carbon substrate catalyst has been designed using etching and a low-temperature treatment method. Studies show that the superior performance of this catalyst is related to the hollow-structured N-doped carbon frame and surface reconstruction of the Ru-Co alloy.

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