In vivo GABA detection by single-pulse editing with one shot.

Purpose: Two-shot γ-aminobutyric acid (GABA) difference editing techniques have been used widely to detect the GABA H4 resonance at 3.01 ppm. Here, we introduce a single-shot method for detecting the full GABA H2 resonance signal, which avoids contamination from the coedited M macromolecules.

Factors governing formation from methyl halogens and pseudohalogens.

The formation of following the double ionization of small organic compounds via a roaming mechanism, which involves the generation of H and subsequent proton abstraction, has recently garnered significant attention. Nonetheless, a cohesive model explaining trends in the yield of characterizing these unimolecular reactions is yet to be established. We report yield and femtosecond time-resolved measurements following the strong-field double ionization of CHX molecules, where X = OD, Cl, NCS, CN, SCN, and I.

Comprehensive analysis of heterogeneity and cell-cell interactions in Crohn's disease reveals novel location-specific insights.

Introduction: In Crohn's disease (CD), lesions are mainly distributed in a segmental manner, with the primary sites of involvement being the ileum and colon. Heterogeneity in colon and ileum results in location-specific clinical presentations and therapeutic responses. Mucosal healing tends to be more readily and quickly achieved in the colon than in the ileum, where lesions are more likely to develop into complex behaviors.

Mapping the knowledge landscape: A bibliometric analysis of exosome research in osteoarthritis (2004-2023).

Exosomes have emerged as a crucial focus in advancing the diagnosis and treatment of osteoarthritis (OA). However, there are limited bibliometric studies on this topic. This study aimed to delineate the literature landscape on exosomes in OA, identifying global research trends and key areas.

Selectivity promotion of Cu by manganese oxide in hydrogenative ring opening of furfural to pentanediols.

This work reports a targeted activation of C-O-C of furfural alcohol (FA) to produce pentanediols (PeDs) over MnO-modified Cu. Infrared spectroscopy revealed the strong interaction of the furan ring and C-O-C of FA with the catalyst surface in a preferred flat adsorption configuration, thus facilitating the activation and cleavage of C-O-C to form PeDs.

Macropinocytosis enhances foamy macrophage formation and cholesterol crystallization to activate NLRP3 inflammasome after spinal cord injury.

After spinal cord injury (SCI), phagocytes endocytose myelin debris to form foam cells, exacerbating the inflammatory response. It has been previously shown that macrophages become foam cells through the phagocytosis of myelin debris via receptor-dependent mechanisms after SCI. Blocking receptor-mediated endocytosis did not completely prevent foam cell formation, so we investigated receptor-independent endocytosis.

Case report: A rare case of renal epithelioid angiosarcoma.

Primary renal epithelioid angiosarcoma (EAS) is extremely rare and carries a poor prognosis. Herein, we present a case of renal EAS in an 81-year-old male patient who complained of hematuria for 1 year. A computerized tomography (CT) scan revealed an occupying lesion at the upper pole of the left kidney, with scattered calcifications, along with retroperitoneal lymph node metastasis and possible lung metastasis.

CGPDTA: An Explainable Transfer Learning-Based Predictor With Molecule Substructure Graph for Drug-Target Binding Affinity.

Identifying interactions between drugs and targets is crucial for drug discovery and development. Nevertheless, the determination of drug-target binding affinities (DTAs) through traditional experimental methods is a time-consuming process. Conventional approaches to predicting drug-target interactions (DTIs) frequently prove inadequate due to an insufficient representation of drugs and targets, resulting in ineffective feature capture and questionable interpretability of results.

A Record-High Cryogenic Magnetocaloric Effect Discovered in EuCl Compound.

Adiabatic demagnetization refrigeration (ADR) based on the magnetocaloric effect (MCE) is a promising technique to achieve cryogenic temperature. However, magnetic entropy change (Δ), the driving force of ADR, remains far below theoretical -Δ = ln(2 + 1)/ for most magnetic refrigerants. Here, we report giant MCE in orthorhombic EuCl, where a ferromagnetic ground state with excellent single-ion behavior of Eu and free spins has been demonstrated by combining calculations with Brillouin function analysis and magnetic measurements.

Revealing multi-level shortrange migration of electrons on full-spectrum response e-LDH/t-BiOCl/BiS and their essential role in the detoxification of Cr(VI) and refractory organic pollutants.

The toxic dyeing wastewater containing both carcinogenic Cr(VI) and refractory dyes poses serious threats to ecological safety and human health. Herein, a novel composite photocatalytic material e-LDH/t-BiOCl/BiS with an ultrathin sandwich structure constructed achieves removal rate constants of 0.044 and 0.

Nano-Silica-Based Double-Layer Antireflective Coatings with Mildew Resistance and Moisture Resistance for KDP Crystals.

Sol-gel nano-silica antireflective (AR) coatings with moisture resistance are widely used for optical elements, such as potassium dihydrogen phosphate (KDP) crystals, but their mildew resistance is often disregarded. This work reports a double-layer AR coating with moisture resistance and mildew resistance for KDP crystals. A polydimethylsiloxane-modified dense silica coating and a quaternary ammonium salt (QAS) modified nanoporous silica coating are selected as the bottom layer and top layer, which effectively serve as a moisture barrier and an antireflection layer, respectively.

Prognostic Prediction for Recurrent/Residual CIN in HSIL Patients After Conization: An Updated Retrospective Study Based on Ambulatory Surgery.

Background: There are currently few prognostic models for conization in patients with high-grade squamous intraepithelial lesion (HSIL) because it is a rapid procedure that typically collects less case information. The present study aimed to establish a rapid/accurate postoperative prognostic assessment model for these patients.

Methods: This study included 631 nonpregnant participants with HSIL confirmed by histopathology from January 2015 to January 2018.

CPIScore: A Deep Learning Approach for Rapid Scoring and Interpretation of Protein-Ligand Binding Interactions.

Protein-ligand binding affinity prediction is a crucial and challenging task in the field of drug discovery. However, traditional simulation-based computational approaches are often prohibitively time-consuming, limiting their practical utility. In this study, we introduce a novel deep learning method, CPIScore, which leverages the capabilities of Transformer and Graph Convolutional Networks (GCN) to enhance the prediction of protein-ligand binding affinity.

Boosted the thermal conductivity of liquid metal via bridging diamond particles with graphite.

The liquid metal (LM) composite is regarded as having potential and wide-ranging applications in electronic thermal management. Enhancing the thermal conductivity of LM is a crucial matter. Herein, a novel LM composite of eutectic gallium-indium (EGaIn)/diamond/graphite was developed.

Novel miRNA markers and their mechanism of esophageal squamous cell carcinoma (ESCC) based on TCGA.

MicroRNAs(miRNAs) are promising biomarkers for early esophageal squamous cell carcinoma (ESCC) detection and prognostic prediction. This study aimed to explore the potential biomarkers and molecular pathogenesis in the early diagnosis of ESCC. Firstly, 48 differentially expressed miRNAs (DEMs) and 1319 differentially expressed genes (DEGs) were identified between 94 ESCC tissues and 13 normal esophageal tissues in TCGA.

Preclinical study and phase 2 trial of neoadjuvant pyrotinib combined with chemotherapy in luminal/HER2-low breast cancer: PILHLE-001 study.

The prognosis of patients with luminal/human epidermal growth factor receptor 2 (HER2)-low early breast cancer (EBC) needs to be improved. This preclinical study and phase 2 trial (ChiCTR2100047233) aims to explore the efficacy and safety of pyrotinib (a pan-HER tyrosine kinase inhibitor) plus chemotherapy in this population. Our preclinical experiments indicate a synergistic anti-tumor effect of pyrotinib plus chemotherapy in luminal/HER2-low (immunochemistry [IHC] 2+/fluorescent in situ hybridization [FISH]-negative) breast cancer models.

Clinical features and predictive nomogram for fatigue sequelae in non-severe patients infected with SARS-CoV-2 Omicron variant in Shanghai, China.

Background: Patients with coronavirus disease 2019(COVID-2019) infections may still experience long-term effects, with fatigue being one of the most frequent ones. Clinical research on the long COVID in the Chinese population after infection is comparatively lacking.

Objective: To collect and analyze the long-term effects of non-severe COVID-19 infection patients and to develop a model for the prediction of fatigue symptoms.

Factors associated with mortality and functional outcome after decompressive craniectomy in malignant middle cerebral artery infarction.

Objective: Identifying the predictive factors of mortality and functional outcomes following decompressive craniectomy (DC) surgery in patients with malignant middle cerebral artery infarction (MMCAI) is essential for decision-making regarding conservative versus surgical treatment. This study aimed to assess the mortality and functional outcomes of MMCAI patients after DC surgery and to identify the predictive factors associated with mortality and functional outcomes.

Methods: A total of 76 patients with MMCAI who underwent surgical DC were included.

The molecular mechanism of PLD2-mediated regulation of apoptosis and cell edema in pancreatic cells via the Nrf2/NF-κB pathway.

This study aimed to elucidate the molecular mechanisms by which PLD2 controls apoptosis and edema in pancreatic cells via the Nrf2/NF-κB pathway. AR42J rat pancreatic cells were treated with 10 nM mitomycin to create an in vitro pancreatitis model (model group), with a control group receiving phosphate-buffered saline. Cells were transfected with a PLD2 overexpression plasmid using Lipofectamine 3000, forming the PLD2 overexpression group.

Viscoelastic synthetic antigen-presenting cells for augmenting the potency of cancer therapies.

The use of synthetic antigen-presenting cells to activate and expand engineered T cells for the treatment of cancers typically results in therapies that are suboptimal in effectiveness and durability. Here we describe a high-throughput microfluidic system for the fabrication of synthetic cells mimicking the viscoelastic and T-cell-activation properties of antigen-presenting cells. Compared with rigid or elastic microspheres, the synthetic viscoelastic T-cell-activating cells (SynVACs) led to substantial enhancements in the expansion of human CD8 T cells and to the suppression of the formation of regulatory T cells.