High-Throughput Screening and General Synthesis Strategy of Single-Atom Nanozymes for Oral Squamous Cell Carcinoma Therapy.

Single-atom nanozymes (SAzymes), with their superior enzyme-like catalytic activity, have emerged as promising candidates for oncology therapeutics. The well-defined structures of SAzymes make them well predictable by experiences and theoretical calculation. However, the effects of metal center species and coordination environments on enzyme-like activity are variable, and screening catalytic activity by artificial experiments is challenging.

Understanding the Dynamic Evolution of Active Sites among Single Atoms, Clusters, and Nanoparticles.

Catalysis remains a cornerstone of chemical research, with the active sites of catalysts being crucial for their functionality. Identifying active sites, particularly during the reaction process, is crucial for elucidating the relationship between a catalyst's structure and its catalytic property. However, the dynamic evolution of active sites within heterogeneous metal catalysts presents a substantial challenge for accurately pinpointing the real active sites.

Effects of typical plant growth regulator chlormequat chloride on alkaloidal compounds in Corydalis yanhusuo and molecular mechanisms.

The effects of chlormequat chloride, a typical plant growth regulator, on the medicinal herb Corydalis yanhusuo were investigated. A standardized field experiment was conducted to investigate the molecular mechanisms and variations in active compounds resulting from chlormequat chloride treatment. Samples of C.

The bidirectional relationship between intrinsic capacity and catastrophic health expenditure in China: A Longitudinal Study.

Background: Intrinsic capacity (IC), as a potential proxy for healthy ageing, guidance on framing the concept is limited. Furthermore, research on the relationship between IC and catastrophic health expenditure (CHE) is scarce.The current study aims to construct a validated IC framework using structural equation modelling (SEM) and examine such an association among older adults in China.

Establishing a peritoneal dialysis technique survival core outcome measure: A standardised outcomes in nephrology-peritoneal dialysis consensus workshop report.

Background: Technique survival, also reported with negative connotations as technique failure or transfer from peritoneal dialysis to haemodialysis, has been identified by patients, caregivers and health professionals as a critically important outcome to be reported in all trials. However, there is wide variation in how peritoneal dialysis technique survival is defined, measured and reported, leading to difficulty in comparing or consolidating results.

Methods: We conducted an online international consensus workshop to establish a core outcome measure of technique survival.

Mediating effects of physical activities and cognitive function on the relationship between dietary diversity and all-cause mortality in community-dwelling older adults.

Background: Although dietary diversity (DD) has been confirmed to be associated with multiple health outcomes and longevity in older people, the related mechanisms have not been elucidated. In this study, we explored the mediating roles of physical activities and cognitive function in the relationship between DD and all-cause mortality.

Methods: We recruited 34 068 community-dwelling older adults aged ≥60 years from the Chinese Longitudinal Healthy Longevity Study and followed them up until 2018.

Burden of non-communicable diseases due to population ageing in China: challenges to healthcare delivery and long term care services.

China has made substantial progress in healthcare delivery to reduce the burden of non-communicable diseases due to population ageing, although challenges and opportunities in long term care services have been under-recognised, argue

Upcycling of Polyamide Wastes to Tertiary Amines Using Mo Single Atoms and Rh Nanoparticles.

The pursuit of sustainable practices through the chemical recycling of polyamide wastes holds significant potential, particularly in enabling the recovery of a range of nitrogen-containing compounds. Herein, we report a novel strategy to upcycle polyamide wastes to tertiary amines with the assistance of H in acetic acid under mild conditions (e.g.

Eco-friendly production and probiotic purification of agarose degradation products: Oligosaccharides and 3,6-anhydro-L-galactose.

Algal biomass offers a solution to global resource scarcity, with agarose, a key component of Gelidium amansii, containing valuable products like oligosaccharides and 3,6-anhydro-L-galactose. However, current purification methods limit their commercial viability. In this study, we utilized gel filtration chromatography to purify agaro-oligosaccharides and neoagaro-oligosaccharides with varying degrees of polymerization, achieving a novel purification of odd-numbered neoagaro-oligosaccharides.

Measuring Social Functioning in Chronic Kidney Disease.

Social functioning is a key aspect of daily life and is important to patients living with chronic kidney disease (CKD) and their caregivers. Many patients with CKD experience debilitating symptoms and treatment burden that can diminish their social functioning and thereby overall social health, which is the aspect of a person's well-being relating to their interactions and connections with others. In patients with CKD, symptoms (e.

Variations in provider practices in remote patient monitoring on peritoneal dialysis in the USA and Canada.

Automation has allowed clinicians to program PD treatment parameters, all while obtaining extensive individual treatment data. This data populates in a centralized online platform shortly after PD treatment completion. Individual treatment data available to providers includes patients' vital signs, alarms, bypasses, prescribed PD treatment, actual treatment length, individual cycle fill volumes, ultrafiltration volumes, as well as fill, dwell, and drain times.

Carbon and Nutrient Limitations of Microbial Metabolism in Xingkai Lake, China: Abiotic and Biotic Drivers.

Microbial communities are crucial for water quality and biogeochemical cycling in freshwaters. Microbes secrete extracellular enzymes to decompose organic matter for their needs of nutrients and scarce elements. Yet, there is a lack of knowledge on microbial metabolic limitations in freshwaters, especially in lake sediments.

Highly efficient recycling of polyester wastes to diols using Ru and Mo dual-atom catalyst.

The chemical recycling of polyester wastes is of great significance for sustainable development, which also provides an opportunity to access various oxygen-containing chemicals, but generally suffers from low efficiency or separation difficulty. Herein, we report anatase TiO supported Ru and Mo dual-atom catalysts, which achieve transformation of various polyesters into corresponding diols in 100% selectivity via hydrolysis and subsequent hydrogenation in water under mild conditions (e.g.

Transient social-ecological dynamics reveal signals of decoupling in a highly disturbed Anthropocene landscape.

Understanding the transient dynamics of interlinked social-ecological systems (SES) is imperative for assessing sustainability in the Anthropocene. However, how to identify critical transitions in real-world SES remains a formidable challenge. In this study, we present an evolutionary framework to characterize these dynamics over an extended historical timeline.

Simultaneous Screening of 172 Veterinary Drugs by Modified QuEChERS-LC-MS/MS in TCM Galli Gigerii Endothelium Corneum.

An analytical method was developed for the screening of 172 veterinary drugs in traditional Chinese medicine Galli Gigerii Endothelium Corneum by high-performance liquid chromatography tandem mass spectrometry. The samples were pretreated by a modified QuEChERS method. A Zorbax Eclipse plus C18 column (1.

International variations in serum PTH and calcium levels and their mortality associations in peritoneal dialysis patients: Results from PDOPPS.

Background: Mineral bone disorder (MBD) in chronic kidney disease (CKD) is associated with high symptom burden, fractures, vascular calcification, cardiovascular disease and increased morbidity and mortality. CKD-MBD studies have been limited in peritoneal dialysis (PD) patients. Here, we describe calcium and parathyroid hormone (PTH) control, related treatments and mortality associations in PD patients.

Construction of an instrument to enable the assessment of the risk of falls in older outpatients: A quantitative methodological study.

Objectives: To develop an instrument to facilitate the risk assessment of falls in older outpatients.

Design: A quantitative methodological study using the cross-sectional data.

Methods: This study enrolled 1988 older participants who underwent comprehensive geriatric assessment (CGA) in an outpatient clinic from May 2020 to November 2022.

Combined associations of cognitive impairment and psychological resilience with all-cause mortality in community-dwelling older adults.

Background: Cognitive impairment and psychological resilience are closely related in older adults, but their combined effect on mortality has not been reported. Using a nationally representative sample from the Chinese Longitudinal Healthy Longevity Study, this study examined the interactions between cognitive impairment and psychological resilience and their associations with overall survival.

Methods: A total of 32,349 community-dwelling older adults (86.