The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis.

Emerging evidence demonstrates that cryptic translation from RNAs previously annotated as noncoding might generate microproteins with oncogenic functions. However, the importance and underlying mechanisms of these microproteins in alternative splicing-driven tumor progression have rarely been studied. Here, we show that the novel protein TPM3P9, encoded by the lncRNA tropomyosin 3 pseudogene 9, exhibits oncogenic activity in clear cell renal cell carcinoma (ccRCC) by enhancing oncogenic RNA splicing.

Design strategy and research progress of multifunctional nanoparticles in lung cancer therapy.

Introduction: Lung cancer is one of the cancer types with the highest mortality rate, exploring a more effective treatment modality that improves therapeutic efficacy while mitigating side effects is now an urgent requirement. Designing multifunctional nanoparticles can be used to overcome the limitations of drugs and conventional drug delivery systems. Nanotechnology has been widely researched, and through different needs, suitable nanocarriers can be selected to load anti-cancer drugs to improve the therapeutic effect.

Long-term stability of several endocrine disruptors in the first morning urine samples and their associations with lifestyle characteristics.

Parabens, triclosan (TCS), bisphenols, benzophenones, and phthalates are typical endocrine disruptors (EDs) with short half-lives in the human body. The concentration levels of those EDs in a spot urine sample are frequently used in exposure assessment studies, and the reproducibility of urinary levels of these nonpersistent EDs should be considered. In the present study, we consecutively collected 45-day first morning void (FMV) urine samples, as well as daily questionnaires, in six recruited participants and measured the urinary concentrations of six parabens, TCS, nine bisphenols, five benzophenones, and ten phthalate metabolites by using high-performance liquid chromatography-tandem mass spectrometry.

Polycyclic aromatic hydrocarbon exposure and DNA oxidative damage of workers in workshops of a petrochemical group.

The petrochemical industry has promoted the development of economy, while polycyclic aromatic hydrocarbons (PAHs) produced by the industry become the threat for environment and humans. Data on human occupational exposure in petrochemical industry are limited. In the present study, urinary hydroxylated PAH metabolites (OH-PAHs) and a biomarker of DNA oxidative damage (8-hydroxy-2'-deoxyguanosine (8-OHdG)) were measured in 546 workers of a petrochemical group in Northeast China, to investigate PAH exposure and related potential health risk.

Feminine Hygiene Products-A Neglected Source of Phthalate Exposure in Women.

Phthalates have been associated with reproductive toxicity and precocious puberty in females, but the occurrence of these toxicants in feminine hygiene products is rarely reported. In this study, eight phthalates were determined in 120 feminine hygiene products (56 feminine care products and 64 sanitary napkins) collected from China. Phthalates were found in 86% and 98% of feminine care products and sanitary napkins, respectively, with the total concentrations varying between not detectable and 813 μg/g (median: 0.

[Effect of transfusing blood components containing on infection in BALB/c mice].

Objective: To evaluate the effects of intravenous injection of different blood components containing on infection in mice.

Methods: Healthy mice were infected with , and then blood samples were collected from the mouse orbit to prepare whole blood, serum-free blood components and pure red blood cells containing . Twenty seven BALB/c mice were divided into three groups, including the whole blood group, the serum-free blood component group and the pure red blood cell group, of 9 mice in each group, and then, each group was divided into three subgroups, of 3 mice in each subgroup, which were injected with 100 μL of blood components containing at concentrations of 9.

Hydroxylated polycyclic aromatic hydrocarbons in surface soil in an emerging urban conurbation in South China.

To investigate the effects of human activity on contaminants in regional soil, hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) were measured in 187 surface soil samples of different land-use types collected from the Pearl River Delta (PRD), South China. The concentrations of ΣOH-PAH (sum of nine target analytes) ranged from 0.36 to 252ng/g (median: 5.

[Dynamics of routine blood tests in BALB/c mice with infection].

Objective: To understand the changes in body weight, spleen weight and complete blood cells in BALB/c mice infected with .

Methods: For the infection group, six weeks old BALB/c mice were injected intraperitoneally with a dose of 100 μL of infected blood (20% RBC infection rate, each mouse). For the determination of the progression of infection up to 28 days of the infection, the microscopic visualization of thin blood smears of tail blood stained with Giemsa staining was performed in the infection group.

Integrated Giant Magnetoresistance Technology for Approachable Weak Biomagnetic Signal Detections.

With the extensive applications of biomagnetic signals derived from active biological tissue in both clinical diagnoses and human-computer-interaction, there is an increasing need for approachable weak biomagnetic sensing technology. The inherent merits of giant magnetoresistance (GMR) and its high integration with multiple technologies makes it possible to detect weak biomagnetic signals with micron-sized, non-cooled and low-cost sensors, considering that the magnetic field intensity attenuates rapidly with distance. This paper focuses on the state-of-art in integrated GMR technology for approachable biomagnetic sensing from the perspective of discipline fusion between them.

The N-butyl alcohol extract from Hibiscus rosa-sinensis L. flowers enhances healing potential on rat excisional wounds.

Ethno-pharmacological Relevance: Hibiscus rosa-sinensis L. (HRS), a folk medicine named Zhujin in China, possess anti-tumor, antioxidant, antibacterial, low density lipoprotein oxidation prevention and macrophage death prevention effects. The leaves and red flowers of HRS have been traditionally used to treat with furuncle and ulceration.

Effects of reconstructed magnetic field from sparse noisy boundary measurements on localization of active neural source.

Localization of active neural source (ANS) from measurements on head surface is vital in magnetoencephalography. As neuron-generated magnetic fields are extremely weak, significant uncertainties caused by stochastic measurement interference complicate its localization. This paper presents a novel computational method based on reconstructed magnetic field from sparse noisy measurements for enhanced ANS localization by suppressing effects of unrelated noise.

Multi-motion robots control based on bioelectric signals from single-channel dry electrode.

This article presents a multi-motion control system to help severe disabled people operate an auxiliary appliance using neck-up bioelectric signals measured by a single-channel dry electrode on the forehead. The single-channel dry-electrode multi-motion control system exhibits several practical advantages over its conventional counterparts that use multi-channel wet-electrodes; among the challenges is an effective technique to extract bioelectric features for reliable implementation of multi degrees-of-freedom motion control. Using both time and frequency characteristics of the single-channel dry-electrode measurements, motion commands are derived from multiple feature signals associated with concentration demands and different eye-blink actions for use in a two-level control strategy that has been developed to control predefined multi degrees-of-freedom motion trajectories.

ABT-737 induces Bim expression via JNK signaling pathway and its effect on the radiation sensitivity of HeLa cells.

ABT-737 is a BH3 mimetic small molecule inhibitor that can effectively inhibit the activity of antiapoptotic Bcl-2 family proteins including Bcl2, Bcl-xL and Bcl-w, and further enhances the effect of apoptosis by activating the proapoptotic proteins (t-Bid, Bad, Bim). In this study, we demonstrate that ABT-737 improved the radiation sensitivity of cervical cancer HeLa cells and thereby provoked cell apoptosis. Our results show that ABT-737 inhibited HeLa cell proliferation and activated JNK and its downstream target c-Jun, which caused the up-regulation of Bim expression.

[Effect of signal transduction inhibitors on human endometrial carcinoma cells with differential PTEN gene expression].

Objective: To investigate the apoptotic and proliferation effects of signal transduction inhibitors on human endometrial carcinoma cells with different PTEN gene expression.

Methods: PTEN antisense oligonucleotide and pcDNA3.1/PTEN vector contained PTEN gene were transfected into endometrial carcinoma cells (HEC-1A and Ishikawa).

Effect of hepatitis B immunoglobulin on interruption of HBV intrauterine infection.

Aim: To evaluate the efficacy of hepatitis B immunoglobulin (HBIG) in interrupting hepatitis B virus (HBV) intrauterine infection during late pregnancy.

Methods: We allocated 112 HBsAg positive pregnant women into 2 groups randomly. Fifty seven cases in the HBIG group received 200 IU (unit) HBIG intramuscularly every 4 wk from the 28 wk of gestation to the time of delivery, while 55 cases in the control group received no special treatment.

[A new method for amplification and sequence analysis of the full-length of HBV genome].

Objectives: To develop a new method for amplifying and sequencing the full-length of HBV genome.

Methods: A pair of primers located at the nick region of HBV molecule and a thermostable polymerase with high fidelity and sensitivity were used. After cloning the PCR products into a plasmid, the sequences of HBV genome were analyzed.

Interruption of HBV intrauterine transmission: a clinical study.

Aim: To investigate the effect of hepatitis B virus (HBV) specific immunoglobin (HBIG) and lamivudine on HBV intrauterine transmission in HBsAg positive pregnant women.

Methods: Each subject in the HBIG group (56 cases) was given 200 IU HBIG intramuscularly (im.) every 4 weeks from 28-week (wk) of gestation, while each subject in the lamivudine group (43 cases) received 100 mg lamivudine orally (po.