Optical and Photocatalytic Properties of Br-Doped BiOCl Nanosheets with Rich Oxygen Vacancies and Dominating {001} Facets.

Crystal facet engineering and nonmetal doping are regarded as effective strategies for improving the separation of charge carriers and photocatalytic activity of semiconductor photocatalysts. In this paper, we developed a facial method for fabricating oxygen-deficient Br-doped BiOCl nanosheets with dominating {001} facets through a traditional hydrothermal reaction and explored the impact of the Br doping and specific facets on carrier separation and photocatalytic performance. The morphologies, structures, and optical and photocatalytic properties of the obtained products were characterized systematically.

A Nomogram Combining Neutrophil-to-Lymphocyte Ratio and D-Dimer Predicts Chemosensitivity of Oxaliplatin-Based First-Line Chemotherapy in Patients with Unresectable Advanced Gastric Cancer.

No effective peripheral blood predictors have been establoshed for first-line chemotherapy in patients with advanced gastric cancer. In this study, a nomogram combining the neutrophil-to-lymphocyte ratio/D-dimer with gender, number of metastases, and histological grade was established to predict progression-free survival in patients with unresectable advanced gastric cancer. We retrospectively collected baseline clinical characteristics and blood parameters from 153 patients diagnosed with advanced gastric cancer that underwent oxaliplatin-based first-line chemotherapy.

Chiral Supramolecular Hydrogel Loaded with Dimethyloxalyglycine to Accelerate Chronic Diabetic Wound Healing by Promoting Cell Proliferation and Angiogenesis.

Chronic refractory wounds are one of the most serious complications of diabetes, and the effects of common treatments are limited. Chiral hydrogel combined with dimethyloxalyglycine (DMOG) as a dressing is a promising strategy for the treatment of chronic wounds. In this research, we have developed a DMOG-loaded supramolecular chiral amino-acid-derivative hydrogel for wound dressings for full-thickness skin regeneration of chronic wounds.

N-methyladenosine (mA) methyltransferase METTL3 regulates sepsis-induced myocardial injury through IGF2BP1/HDAC4 dependent manner.

Recent studies have identified that N-methyladenosine (mA) extensively participates in the myocardial injury pathophysiological process. However, the role of mA on sepsis-induced myocardial injury is still unclear. Here, we investigated the functions and mechanism of mA methyltransferase METTL3 for septic myocardial injury.

Essential role of IL-17 in acute exacerbation of pulmonary fibrosis induced by non-typeable .

Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) has a poor prognosis and lacks effective therapy. Animal models that mimic AE-IPF can greatly accelerate investigation of its pathogenesis and development of effective therapy. However, there are few reports of animal models of AE-IPF caused by bacteria.

Air or soil temperature matters the responses of alpine plants in biomass accumulation to climate warming.

Climate change has substantially affected plant phenology and growth on the Qinghai-Tibetan Plateau (QTP), while it remains unclear how plant phenology and growth impact the plant biomass under climate change. We used long-term data (from 1997 to 2017) for four plants, Stipa purpurea, Artemisia scoparia, Kobresia humilis and Astragalus laxmannii in the alpine meadow to examine the relationships among multiple climate factors, vegetative growth, reproductive growth, intrinsic growth rate and biomass. The order of returning to green determines the growth strategies of different plants, the earliest plants to green (p < 0.

A General Map of Transcriptional Expression of Virulence, Metabolism, and Biofilm Formation Adaptive Changes of When Exposed to Different Antimicrobials.

Biofilm formation of is the major cause of implant-associated infections (IAIs). Antimicrobial treatment is one of the most effective therapeutic options for infections. However, it can also lead to adaptive transcriptomic changes due to extreme selective pressure, which may increase the risk of antimicrobial resistance.

The Crosstalk Between Immune Infiltration, Circulating Tumor Cells, and Metastasis in Pancreatic Cancer: Identification of HMGB3 From a Multiple Omics Analysis.

Metastasis is the major cause of death in patients with pancreatic ductal adenocarcinoma (PDAC), and circulating tumor cells (CTCs) play an important role in the development of metastasis. However, few studies have uncovered the metastasis mechanism of PDAC based on CTCs. In this study, the existing bulk RNA-sequencing (bulk RNA-seq) and single-cell sequencing (scRNA-seq) data for CTCs in pancreatic cancer were obtained from the Gene Expression Omnibus (GEO) database.

Sappanwood-derived polyphenolic antidote of amyloidal toxins achieved detoxification via inhibition/reversion of amyloidal fibrillation.

The formidable virulence of methicillin-resistant staphylococcus aureus (MRSA) have thrown great challenges to biomedicine, which mainly derives from their autocrine phenol-soluble modulins (PSMs) toxins, especially the most toxic member termed phenol-soluble modulins α3 (PSMα3). PSMα3 cytotoxicity is attributed to its amyloidal fibrillation and subsequent formation of cross-α sheet fibrils. Inspired by the multiple biological activity of Sappanwood, herein, we adopted brazilin, a natural polyphenolic compound originated from Caesalpinia sappan, as a potential antidote of PSMα3 toxins, and attempted to prove that the regulation of PSMα3 fibrillation was an effective alexipharmic way for MRSA infections.

Combining Clinicopathology, IVIM-DWI and Texture Parameters for a Nomogram to Predict Treatment Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Patients.

Objectives: This study aimed to create a nomogram for the risk prediction of neoadjuvant chemoradiotherapy (nCRT) resistance in locally advanced rectal cancer (LARC).

Methods: Clinical data in this retrospective study were collected from a total of 135 LARC patients admitted to our hospital from June 2016 to December 2020. After screening by inclusion and exclusion criteria, 62 patients were included in the study.

Intermittent Sampled-Data Control for Local Stabilization of Neural Networks Subject to Actuator Saturation: A Work-Interval-Dependent Functional Approach.

This article is concerned with the local stabilization of neural networks (NNs) under intermittent sampled-data control (ISC) subject to actuator saturation. The issue is presented for two reasons: 1) the control input and the network bandwidth are always limited in practical engineering applications and 2) the existing analysis methods cannot handle the effect of the saturation nonlinearity and the ISC simultaneously. To overcome these difficulties, a work-interval-dependent Lyapunov functional is developed for the resulting closed-loop system, which is piecewise-defined, time-dependent, and also continuous.

The Temporal Impact of Prosthesis Implantation and Semi-Quantitative Criteria on the Diagnostic Efficacy of Triple-Phase Bone Scanning for Periprosthetic Joint Infection.

Objective: To evaluate the diagnostic efficacy of triple-phase bone scanning and the temporal impact of prosthesis implantation on the diagnostic efficacy of triple-phase bone scanning for periprosthetic joint infection (PJI).

Methods: Patients who were admitted to our hospital for joint pain and dysfunction after total joint arthroplasty between 2014 and 2020 were retrospectively included. Triple-phase bone scanning was performed, and the blood pool images were evaluated to obtain the semi-quantitative criteria.

MiR-186-5p Downregulates NAMPT and Functions as a Potential Therapeutic Target for Sepsis-Induced Coagulation Disorders.

Purpose: Present study is aimed to explore the role of miR-186-5p in sepsis-induced coagulation disorders and molecular mechanisms.

Methods: Thirty-four sepsis patients and 34 respiratory infection/pneumonia patients were selected in the present study. Polymicrobial sepsis model was created by cecal ligation and puncture (CLP).

Phyllosphere bacterial and fungal communities vary with host species identity, plant traits and seasonality in a subtropical forest.

Background: Phyllosphere microbes play important roles in host plant performance and fitness. Recent studies have suggested that tropical and temperate forests harbor diverse phyllosphere bacterial and fungal communities and their assembly is driven by host species identity and plant traits. However, no study has yet examined how seasonality (e.

An auto-photoacoustic melanin-based drug delivery nano-platform for self-monitoring of acute kidney injury therapy via a triple-collaborative strategy.

Rhabdomyolysis-induced acute kidney injury (AKI) is closely related to toxic reactive oxygen species (ROS), apoptosis, and inflammation. Excessive activation of poly (ADP-ribose) polymerase-l (PARP-1) by ROS can cause mitochondrial dysfunction and release of the proapoptotic protein AIF, which triggers an intrinsic PARP-1-dependent cell death program. Considering these characteristics of rhabdomyolysis-induced AKI, we developed a targeting nanodrug delivery platform by loading PJ34 and coupling anti-GPR97 with melanin nanoparticles (GMP nanoparticles) that could realize photoacoustic self-monitoring and triple-collaborative treatment (antioxidant, antiapoptotic, and anti-inflammatory).

Natural antisense RNA Foxk1-AS promotes myogenic differentiation by inhibiting Foxk1 activity.

Background: Natural antisense RNAs are RNA molecules that are transcribed from the opposite strand of either protein-coding or non-protein coding genes and have the ability to regulate the expression of their sense gene or several related genes. However, the roles of natural antisense RNAs in the maintenance and myogenesis of muscle stem cells remain largely unexamined.

Methods: We analysed myoblast differentiation and regeneration by overexpression and knockdown of Foxk1-AS using lentivirus and adeno-associated virus infection in C2C12 cells and damaged muscle tissues.

First Indirect Drive Experiment Using a Six-Cylinder-Port Hohlraum.

The new hohlraum experimental platform and the quasi-3D simulation model are developed to enable the study of the indirect drive experiment using the six-cylinder-port hohlraum for the first time. It is also the first implosion experiment for the six laser-entrance-hole hohlraum to effectively use all the laser beams of the laser facility that is primarily designed for the cylindrical hohlraum. The experiments performed at the 100 kJ Laser Facility produce a peak hohlraum radiation temperature of ∼222  eV for ∼80  kJ and 2 ns square laser pulse.

The Cytochrome P450 2C19 Polymorphism Associated with Major Adverse Cardiovascular Events Risk in Kazak Patients Undergoing Percutaneous Coronary Intervention and Receiving Clopidogrel.

Background: Clopidogrel activity is influenced by cytochrome P450 (CYP450). CYP2C19 polymorphisms vary by ethnicity and region.

Objective: The aim of the study is to assess the effect of genetic polymorphisms in CYP2C19*2 and *3 and clinical and demographic factors on major adverse cardiovascular events (MACE) in Kazak patients following percutaneous coronary intervention (PCI).

Efficient classification of Escherichia coli and Shigella using FT-IR spectroscopy and multivariate analysis.

Accurate and effective discrimination of E. coli and Shigella is an important clinical issue, and there are many limitations in traditional methods of analysis. FT-IR shows great potential in the classification of bacteria with high specificity and low cost.

Multifunctional TiCT MXene-Based Composite Coatings with Superhydrophobic Anti-icing and Photothermal Deicing Properties.

Although advances in industrial products have brought convenience to our lives, severe weather has increased the safety risks to industrial facilities. Considerable efforts have been made to develop high-performance superhydrophobic anti-icing coatings. Nevertheless, designing a functional coating with both anti-icing properties and self-deicing remains a major challenge.

Wheel-Running Exercise Protects Ovariectomized Mice from Bone Loss via IFN--Mediated Suppression of the NF-B and MAPK Pathways.

Physical exercise is recommended as a preventative approach for osteoporosis; however, the effect of physical exercise on bone mass remains controversial. Additionally, the immune regulation of physical exercise on bone mass remains unclear. To determine whether wheel-running (WR) exercise contributes to improving bone mineral density (BMD) and investigate the involved immune mechanism, ovariectomized (OVX) and sham-operated mice were treated with 8 weeks of WR exercise.

A nomogram for predicting post-hepatectomy liver failure in patients with hepatocellular carcinoma based on spleen-volume-to-platelet ratio.

Background And Objectives: Post-hepatectomy liver failure (PHLF) is one of the most serious complications after hepatectomy in patients with hepatocellular carcinoma (HCC), and has an association with high morbidity and mortality. This study aimed to explore the risk factors of PHLF and to establish and validate a nomogram to predict PHLF.

Methods: We retrospectively analyzed 971 HCC patients undergoing major liver resection at the Eastern Hepatobiliary Surgery Hospital between 2011 and 2016, and established a nomogram based on multivariate analyses for predicting PHLF.

N Addition Overwhelmed the Effects of P Addition on the Soil C, N, and P Cycling Genes in Alpine Meadow of the Qinghai-Tibetan Plateau.

Although human activities have greatly increased nitrogen (N) and phosphorus (P) inputs to the alpine grassland ecosystems, how soil microbial functional genes involved in nutrient cycling respond to N and P input remains unknown. Based on a fertilization experiment established in an alpine meadow of the Qinghai-Tibetan Plateau, we investigated the response of the abundance of soil carbon (C), N, and P cycling genes to N and P addition and evaluated soil and plant factors related to the observed effects. Our results indicated that the abundance of C, N, and P cycling genes were hardly affected by N addition, while P addition significantly increased most of them, suggesting that the availability of P plays a more important role for soil microorganisms than N in this alpine meadow ecosystem.

Multistability analysis of delayed recurrent neural networks with a class of piecewise nonlinear activation functions.

This paper studies the multistability of delayed recurrent neural networks (DRNNs) with a class of piecewise nonlinear activation functions. The coexistence as well as the stability of multiple equilibrium points (EPs) of DRNNs are proved. With the Brouwer's fixed point theorem as well as the Lagrange mean value theorem, it is obtained that under some conditions, the n-neuron DRNNs with the proposed activation function can have at least 5 EPs and 3 of them are locally stable.