Publications by authors named "Shen Feixia"
This study aimed to comprehensively examine the association of gallstones, cholecystectomy, and cancer risk. Multivariable logistic regressions were performed to estimate the observational associations of gallstones and cholecystectomy with cancer risk, using data from a nationwide cohort involving 239 799 participants. General and gender-specific two-sample Mendelian randomization (MR) analysis was further conducted to assess the causalities of the observed associations.
View Article and Find Full Text PDFBackground: Resistance exercise leads to improved muscle function and metabolic homeostasis. Yet how circadian rhythm impacts exercise outcomes and its molecular transduction remains elusive.
Methods: Human volunteers were subjected to 4 weeks of resistance training protocols at different times of day to assess training outcomes and their associations with myokine irisin.
Article Synopsis
- The study examines how education impacts the prevalence of cardiovascular-kidney-metabolic (CKM) syndrome in middle-aged and older Chinese individuals, highlighting significant gender differences.
- Using data from a large population-based study, researchers found that low educational attainment increased the likelihood of moderate and high CKM syndrome, particularly among women.
- Results suggest that poor health behaviors, influenced by education, significantly affect CKM syndrome risks, emphasizing the need for interventions that address social determinants of health.
Article Synopsis
- Scientists studied how things like education, lifestyle, and health can affect death rates in older adults in China.
- They found that 17 factors were linked to a lot of the deaths, showing that low education and high blood pressure were some of the biggest reasons people died from different causes.
- The study suggested that understanding these risks can help create better health programs to keep people healthier and reduce deaths in China.
Article Synopsis
- Emerging studies suggest a link between medium-chain fatty acids (MCFAs) in the diet and glucose regulation, but the specific role of serum MCFAs in diabetes risk, especially concerning genetic factors, needs further exploration.
- A nested case-control study analyzed baseline serum MCFAs from 1,707 individuals with type 2 diabetes (T2DM) and matched healthy controls, examining both MCFAs' overall effects and their interactions with genetic risk scores based on T2DM-linked genetic variants.
- Results indicated that higher levels of octanoic and nonanoic acids were associated with lower diabetes risk, particularly in physically inactive individuals and those with high genetic risk, suggesting a complex interplay between these fatty acids and genetic predisposition in diabetes
Article Synopsis
- - The study investigates the association between the triglyceride glucose (TyG) index and breast cancer risk in Chinese women, using data from a large sample of 142,184 participants aged 40 or older.
- - Results indicate that women in the highest quartile of the TyG index have a 61% increased risk of prevalent breast cancer compared to those in the lowest quartile, with certain demographics showing even stronger associations.
- - The findings suggest that the TyG index may be a useful marker for assessing breast cancer risk, especially among women without insulin resistance or metabolic issues.
Article Synopsis
- Long-chain free fatty acids (FFAs) have a potential link to diabetes risk, particularly in populations that have normal blood sugar levels, which requires further exploration.
- The study used a comprehensive approach to measure 53 types of FFAs in a cohort of 1,707 individuals who developed diabetes and 1,707 matched controls, employing various statistical models to assess risk associations.
- Findings indicated that odd-chain and specific even-chain FFAs were inversely associated with diabetes risk, with odds ratios suggesting that higher levels of certain saturated, monounsaturated, and polyunsaturated fatty acids could lower the risk of developing diabetes.
Aims: To assess the excess risk of cardiovascular disease (CVD) associated with different criteria for metabolic health, and the interplay of body size, insulin sensitivity and metabolic health with CVD risk.
Materials And Methods: We conducted a prospective study involving 115 638 participants from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. Metabolic health was defined using three different definitions: (1) insulin sensitivity defined by homeostatic model assessment of insulin resistance index; (2) absence of metabolic syndrome according to the National Cholesterol Education Program Adult Treatment Panel III criteria; and (3) simultaneous absence of metabolic abnormalities (diabetes, hypertension, dyslipidaemia).
Background/aims: : Low educational attainment is a well-established risk factor for nonalcoholic fatty liver disease (NAFLD) in developed areas. However, the association between educational attainment and the risk of NAFLD is less clear in China.
Methods: : A cross-sectional study including over 200,000 Chinese adults across mainland China was conducted.
Article Synopsis
- Research shows a U-shaped relationship between sleep duration and chronic kidney disease (CKD), indicating that both insufficient and excessive sleep can negatively affect kidney health.
- A study involving over 100,000 participants found that replacing 1 hour of excessive sleep with physical activities like walking or moderate exercise significantly reduces CKD prevalence, with leisure activities being more effective than occupational ones.
- Long sleepers, especially those with diabetes, benefit more from reallocating time to physical activity, highlighting the need to optimize sleep patterns and overall behavioral activities for better kidney health.
Background: The association between weight change during early adulthood and cardiometabolic diseases remains uncertain in Chinese population. Whether the association varies with comprehensive cardiovascular health (CVH) in midlife assessed by "Life's Essential 8" has not been characterized. We aim to examine the associations of early adulthood weight change and midlife "Life's Essential 8" CVH status with cardiometabolic outcomes in a Chinese cohort.
View Article and Find Full Text PDFImportance: Spouses share common socioeconomic, environmental, and lifestyle factors, and multiple studies have found that spousal diabetes status was associated with diabetes prevalence. But the association of spousal diabetes status and ideal cardiovascular health metrics (ICVHMs) assessed by the American Heart Association's Life's Essential 8 measures with incident diabetes has not been comprehensively characterized, especially in large-scale cohort studies.
Objective: To explore the association of spousal diabetes status and cardiovascular health metrics with risk of incident diabetes in Chinese adults.
Prediabetes and its pathophysiology remain important issues. We aimed to examine the cluster characteristics of prediabetes and explore their associations with developing diabetes and its complications based on 12 variables representing body fat, glycemic measures, pancreatic β cell function, insulin resistance, blood lipids, and liver enzymes. A total of 55,777 individuals with prediabetes from the China Cardiometabolic Disease and Cancer Cohort (4C) were classified at baseline into six clusters.
View Article and Find Full Text PDFAim: We aimed to examine risks of major cardiovascular events (MACEs), renal outcomes, and all-cause mortality in type 2 diabetes mellitus (T2DM) patients with different diabetic kidney disease (DKD) subtypes.
Methods: A total of 36,509 participants with T2DM recruited from 20 community sites across mainland China were followed up during 2011-2016. DKD subtypes were categorized based on albuminuria (urinary albumin-to-creatinine ratio, UACR ≥ 30 mg/g) and reduced estimated glomerular filtration rate (eGFR < 60 ml/min/1.
Background: High blood pressure (BP) is highly prevalent in patients with chronic kidney disease. However, the thresholds to initiate BP-lowering treatment in this population are unclear. We aimed to examine the associations between BP levels and clinical outcomes and provide evidence on potential thresholds to initiate BP-lowering therapy in people with chronic kidney disease.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess how whole fresh fruit intake affects the risk of developing type 2 diabetes (T2D) in individuals with varying glucose regulation, focusing on a large group of non-diabetic participants aged 40 and older in China.
- Over a follow-up period of 3.8 years, researchers found a significant inverse relationship between fruit consumption and diabetes risk; specifically, each additional 100 grams of fruit consumed daily corresponded to a 2.8% reduction in diabetes risk.
- Results indicated that this protective effect was most pronounced in individuals with normal glucose tolerance, while no significant association was observed in those with prediabetes.
Background: Evidence regarding the impact of education on diabetes risk is scarce in developing countries. We aimed to explore the association between education and diabetes within a large population in China and to identify the possible mediators between them.
Methods: Information on educational level and lifestyle factors was collected through questionnaires.
Background: Lack of physical activity and excessive sitting time contributed to ectopic fat accumulation, especially in the liver. Previous studies have illustrated the harm of sedentary behaviour and the benefits of physical activity on fatty liver disease. We aimed to explore the association between the behaviour patterns and the risk of metabolic dysfunction-associated fatty liver disease (MAFLD) using isotemporal substitution model to examine the effect of replacing one behaviour to another while keeping the total time and other behaviours fixed among Chinese middle-aged and elderly population.
View Article and Find Full Text PDFBackground: National investigations of age-specific modifiable risk profiles for diabetes are crucial to promote personalised strategies for the prevention and control of diabetes, particularly in countries such as China, which is experiencing both a diabetes epidemic and a rapidly ageing population. We aimed to examine the associations of 12 potentially modifiable socioeconomic, lifestyle, and metabolic risk factors with diabetes in a nationwide prospective cohort of Chinese adults across four age groups.
Methods: We analysed data from the China Cardiometabolic Disease and Cancer Cohort Study, a nationwide, population-based, cohort study done between Jan 1, 2011, and Dec 31, 2016.
Examining the Linear Association Between Blood Pressure Levels and Cardiovascular Diseases in the Absence of Major Risk Factors in China.
Circ Cardiovasc Qual Outcomes
September 2022
Article Synopsis
- The study investigates the relationship between blood pressure (systolic and diastolic) and cardiovascular disease (CVD) specifically in individuals without major cardiovascular risk factors.
- A large cohort of 36,042 participants was analyzed, focusing on those with optimal glycemic and lipid profiles, over a follow-up period to assess the development of CVD.
- Results showed a significant linear increase in CVD risk for higher blood pressure levels, with specific hazard ratios indicating increased risk associated with certain systolic (110-139 mm Hg) and diastolic (80-89 mm Hg) blood pressure ranges compared to lower levels.
Although previous studies suggest that amino acids (AAs) and microbiota-related metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain unclear among normoglycemic populations. We test 28 serum AAs and 22 MRMs in 3,414 subjects with incident diabetes and matched normoglycemic controls from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. In fully adjusted logistic regression models, per SD increment of branched-chain AAs, aromatic AAs, asparagine, alanine, glutamic acid, homoserine, 2-aminoadipic acid, histidine, methionine, and proline are positively associated with incident T2DM.
View Article and Find Full Text PDFBackgrounds: Whether longitudinal changes in metabolic status influence the effect of kidney stones on cardiovascular disease (CVD) remains unclarified. We investigated the modification effect of status changes in metabolic syndrome (MetS) in the association of kidney stones with risk of incident CVD events.
Methods: We performed a prospective association and interaction study in a nationwide cohort including 129,172 participants aged ≥ 40 years without CVDs at baseline and followed up for an average of 3.
Aim: To determine the effect of decade-based body weight gain from 20 to 50 years of age on later life diabetes risk.
Methods: 35,611 non-diabetic participants aged ≥ 50 years from a well-defined nationwide cohort were followed up for average of 3.6 years, with cardiovascular diseases and cancers at baseline were excluded.
Objective: To investigate whether the association between insulin resistance and cardiovascular disease (CVD) differs by glucose tolerance status.
Research Design And Methods: We analyzed a nationwide sample of 111,576 adults without CVD at baseline, using data from the China Cardiometabolic Disease and Cancer Cohort Study. Insulin resistance was estimated by sex-specific HOMA of insulin resistance (HOMA-IR) quartiles for participants with normal glucose tolerance, prediabetes, or diabetes, separately, and by 1 SD of HOMA-IR for the overall study participants.