Origin of Nonlinear Circular Photocurrent in 2D Semiconductor MoS_{2}.

Nonlinear photogalvanic effects in two-dimensional materials, particularly the nonlinear circular photocurrents (NCPs) that belong to the helicity-dependent spin photocurrents, have sparked enormous research interest. Although notable progress has been witnessed, the underling origin of NCPs remains elusive. Here, we present systematic photocurrent characteristics, symmetry analysis and theoretical calculations to uncover the physical origin of NCPs in MoS_{2}, a prototypical 2D semiconductor.

Accuracy of Large Language Models for Literature Screening in Thoracic Surgery: Diagnostic Study.

Background: Systematic reviews and meta-analyses rely on labor-intensive literature screening. While machine learning offers potential automation, its accuracy remains suboptimal. This raises the question of whether emerging large language models (LLMs) can provide a more accurate and efficient approach.

DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma.

Aims: Emerging resistance to Lenvatinib, which is used as a first-line agent for the treatment of advanced hepatocellular carcinoma (HCC), is still a concern. The aim of this study was to determine core factors of Lenvatinib resistance (LR) and their underlying molecular mechanisms.

Methods: CRISPR screening in HCC cells was conducted, which identified E3 ubiquitin ligase deltex 2 (DTX2) as a core LR-related gene.

Effect of microbe-derived antioxidants on intestinal oxidative stress, NLRP3 inflammasome, morphologic structure, and growth performance in weanling piglets.

Weaning stress induces pigs oxidative stress, which decreases growth performance, causes intestinal damage, and increases diarrhea and death in piglets. Microbe-derived antioxidants (MA) have an antioxidant and immune-modulatory role, but the impacts of MA on growth performance, intestinal oxidative stress, structure and function, and inflammatory response of weaned piglets are unclear. To elucidate whether MA can modulate intestinal oxidative stress, inflammatory response, and barrier function impairment and the possible mechanisms of its modulation, a total of 60 DLY (a crossbreed of Duroc, Landrance, and Yorkshire) piglets were randomly selected from 6 litters, with 10 piglets from each litter.

Population Pharmacokinetic/Pharmacodynamic and Exposure-Response Modeling of Garadacimab in Healthy Volunteers and Patients With Hereditary Angioedema.

Hereditary angioedema (HAE) is a rare genetic disease that manifests as recurrent, unpredictable, and potentially life-threatening attacks of angioedema. Garadacimab is a first-in-class, fully human, monoclonal antibody targeting activated factor XII (FXIIa) that is under clinical development for the long-term prophylaxis of HAE attacks. We developed population pharmacokinetic (PK)/pharmacodynamic (PD)/exposure-response (ER) models using pooled data across clinical studies to quantify the relationship between garadacimab concentration and the relative risk of HAE attacks and to support the rationale for 200 mg once-monthly dosing.

17.68% Efficiency Nonhalogenated Solvent-Processed Organic Solar Cell Modules Driven by Seed Crystal Strategy.

Organic solar cells now surpass 20% efficiency in small-area devices, but the use of chloroform as a solvent poses industrial scalability challenges because of its limited ability of uniform film formation and toxicity. High-boiling, non-halogenated solvents are being studied as alternatives, but their low solubility and slow evaporation complicate crystallization process. Here, the study introduces a seed crystal strategy by incorporating oligo (ethylene glycol)-modified small-molecule donors to optimize the nucleation and crystallization.

A fast and efficient virtual screening and identification strategy for helix peptide binders based on finDr webserver: A case study of bovine serum albumin (BSA).

Peptides offer unique advantages, including strong specificity, rapid action, and low side effects, making them a prominent focus in the development of new drugs and functional materials. However, the rapid and efficient screening and identification of high-affinity peptides for specific targets remains a significant challenge. In this study, we successfully screened 12-helix candidate peptides using bovine serum albumin (BSA) as the target protein, employing the computer-aided peptide virtual screening webserver finDr.

A Comprehensive Review of Advances in Molecular Mechanisms and Targeted Therapies for the Specific Type of Cystic Lung Cancer.

Background And Objective: Cystic lung cancer (CLC) presents diagnostic and treatment challenges due to its complex imaging features and unclear molecular mechanisms. Although surgery and standard chemotherapy are frequently used, there is limited information on targeted therapy and other precision treatments. It is crucial to comprehensively understand the molecular mechanisms and explore precision treatments based on targeted therapy.

The neuroprotective and behavioral improvement effects of glial fibrillary acidic protein (GFAP) molecules on tic disorder: Regulation of the 5-HT system by yohimbine.

Tic disorder is a class of nervous system diseases characterized by involuntary muscle contraction, and its pathogenesis is complex. This study aimed to investigate the mechanism of action of GFAP in tic disorder and its potential influence on neuroprotection and behavior improvement. The expression level of GFAP in brain tissues of each group was detected by immunohistochemistry, and the changes of tic behavior were evaluated by behavioral tests.

Robot-assisted vesicovaginal fistula repair with "Rainbow-shaped" peritoneal flap: a single-center experience.

Purpose: Vesicovaginal fistula (VVF) refers to an abnormal communication between the bladder and vagina, leading to uncontrolled leakage of urine from the vagina. This study aimed to assess the efficacy and safety of robot-assisted laparoscopic VVF repair with a "rainbow-shaped" peritoneal flap.

Methods: A retrospective analysis was conducted on 15 patients who underwent robot-assisted VVF repair from July 2021 to March 2023 in Peking University First Hospital.

Interlayer Parallel Connection of Multiple Helmholtz Resonators for Optional Broadband Low Frequency Sound Absorption.

The Helmholtz resonance acoustic metamaterial is an effective sound absorber in the field of noise reduction, especially in the low-frequency domain. To overcome the conflict between the number of Helmholtz resonators and the volume of the rear cavity for each chamber with a given front area of single-layer metamaterial, a novel acoustic metamaterial of interlayer parallel connection of multiple Helmholtz resonators (IPC-MHR) is proposed in this study. The developed IPC-MHR consists of several layers, and the Helmholtz resonators among different layers are connected in parallel.

An evaluation of a five-year program for newborn congenital heart disease screening in Jiangsu Province, 2019-2023.

Background: Since 2019, Jiangsu province has implemented newborn screening for congenital heart disease (CHD). As of 2023, 591 hospitals (584 public or private midwifery institutions, 7 specialized hospitals for children) in Jiangsu province conduct CHD screening, including 132 with diagnostic capabilities and 21 with treatment facilities, ensuring comprehensive coverage of 13 prefecture-level cities, 95 counties (19 counties, 21 county-level cities, 55 districts) in Jiangsu Province. This study aims to examine the implementation of the newborn CHD screening program within Jiangsu Province's healthcare systems using real-world clinical data and to assess its effectiveness in patient care systematically.

Phylosymbiosis and Parallel Geographical Patterns in the Gut Microbiota of Desert-Dwelling Amphibians and Reptiles.

Variation patterns in gut microbial diversity among host species and populations offer valuable insights into the mechanisms underlying environment-host-microbiome interactions. However, the extent to which host phylogeny and geography drive these variation patterns in animal gut microbiota remains an open question. Amphibians and reptiles are important models to address this issue.

Integrative analysis of genes provides insights into the molecular and immune characteristics of mitochondria-related genes in atherosclerosis.

Atherosclerosis is a chronic inflammatory disease characterized by lipid accumulation in arterial walls. The role of the interplay between mitochondrial dysfunction and immune inflammation in atherosclerosis is still unclear. This study aimed to investigate the molecular characteristics and immune landscape of mitochondrial hub genes involved in atherosclerosis.

Direct probing of energy gaps and bandwidth in gate-tunable flat band graphene systems.

Moiré systems featuring flat electronic bands exhibit a vast landscape of emergent exotic quantum states, making them one of the resourceful platforms in condensed matter physics. Tuning these systems via twist angle and the electric field greatly enhances our comprehension of their strongly correlated ground states. Here, we report a technique to investigate the nuanced intricacies of band structures in dual-gated multilayer graphene systems.

An elbow passive exoskeleton with controllable assistance: Design and experimental.

A passive exoskeleton is a wearable robotic device that is worn on the exterior of the user's body to provide physical support and facilitate movement. Existing elbow passive exoskeletons have limitations in their assistance capabilities and range of applications. In this paper, we propose a controllable elbow passive exoskeleton (CEPE) to address these limitations.

Adaptive Divergence and Functional Convergence: The Evolution of Pulmonary Gene Expression in Amphibians of the Qingzang Plateau.

The Qingzang Plateau, with its harsh environmental conditions-low oxygen, high ultraviolet radiation and significant temperature fluctuations-demands specialised adaptations for survival. While genetic adaptations have been extensively studied, gene expression's role in amphibian adaptation to high elevations remains understudied. This study analysed pulmonary gene expression in 119 amphibians across the plateau to explore how genetic and environmental factors shape expression evolution.

Reassessing the Role of Low PSA in Prognosis Across Grades of Prostate Cancer: A Cohort Study.

Background: Prior studies have concentrated exclusively on how different prostate-specific antigen (PSA) levels affect the prognosis of high-grade prostate cancer (PCa), often overlooking the prognosis of low-grade PCa.

Methods: The present cohort study included individuals diagnosed with PCa from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2021. The all-cause mortality (ACM) and prostate cancer-specific mortality (PCSM) for each treatment group was calculated stratified by the four PSA levels (≤ 4.

Could less be enough: sublobar resection vs lobectomy for clinical stage IA non-small cell lung cancer patients with visceral pleural invasion or spread through air spaces.

Background: While recent randomized controlled trials have demonstrated that sublobar resection (SLR) is non-inferior to lobectomy, the comparative efficacy of these procedures remains uncertain for early-stage non-small cell lung cancer (NSCLC; ≤3 cm) exhibiting invasive features postoperatively, such as visceral pleural invasion (VPI) or spread through air spaces (STAS).

Materials And Methods: To identify eligible studies, a comprehensive search of PubMed, Embase, MEDLINE, the Cochrane Library, and Web of Science was conducted through 25 July 2024. Studies were screened according to predefined criteria in accordance with PRISMA guidelines.

A robust reduction in near-surface wind speed after volcanic eruptions: Implications for wind energy generation.

Near-surface wind speed (NSWS), a determinant of wind energy, is influenced by both natural and anthropogenic factors. However, the specific impacts of volcanic eruptions on NSWS, remain unexplored. Our simulations spanning the last millennium reveal a consistent 2-year global NSWS reduction following 10 major historical eruptions.

Robot-Assisted Radical Prostatectomy Using the KangDuo Surgical Robot-1500: A Prospective, Multicenter, Single-Arm Clinical Study.

The KangDuo Surgical Robot-1500 (KD-SR-1500) is a newly developed surgical robot. We aim to evaluate the feasibility and efficiency of the KD-SR-1500 system for robot-assisted radical prostatectomy (RARP). This prospective, multicenter, single-arm clinical study was conducted among 18-75-year-old patients with suspected T1-2N0M0 prostate cancer scheduled for RARP.

A brain-computer interface system for lower-limb exoskeletons based on motor imagery and stacked ensemble approach.

Existing lower limb exoskeletons (LLEs) have demonstrated a lack of sufficient patient involvement during rehabilitation training. To address this issue and better incorporate the patient's motion intentions, this paper proposes an online brain-computer interface (BCI) system for LLE based motor imagery and stacked ensemble. The establishment of this online BCI system enables a comprehensive closed-loop control process, which includes the collection and decoding of brain signals, robotic control, and real-time feedback mechanisms.

Separation of Three Polar Compounds with Similar Polarities from Swertia mussotii by a Combination of Two Counter-Current Chromatography Modes.

Separation of polar compounds especially with similar polarities is challenging. In the present study, three polar compounds with similar polarities, including gentiopicroside, sweroside and mangiferin, have been successfully separated from Swertia mussotii by a combination of two counter-current chromatography modes. With the selected solvent system of ethyl acetate/n-butanol/water (8/2/10, v/v), a continuous injection mode was firstly employed.