[The content of dynorphin, Met-enk-Arg6-Phe7 and substance P (1-11) in the brain of mice with different levels of ethanol consumption].

The dynorphin A (1-17), Met-enkephalin-Arg6-Phe7 and substance P levels were determined by RIA following Sep-Pak separation in the striatum, hippocampus and spinal cord of three strains of mice (C57Bl10/D1, A/Sn, A. CA). The C57Bl10/D1 mice had high consumption of 10% ethanol at free choice schedule, whereas the A/Sn and A.

[Des-1-tyrosine-gamma-endorphin: an assessment of its neuroleptic properties and effect on dopamine synthesis].

The neuropeptide des-1-tyrosine-gamma-endorphine (DTGE) has been shown to facilitate, similarly to neuroleptics, the extinction of pole-jumping avoidance behavior, to enhance the grasping reflex, and to produce catalepsy. In in vitro experiments, DTGE (10(-4) M) did not change the activity of solubilized rat brain striatal tyrosine hydroxylase. However at the concentration of 10(-4) M and 10(-6) M DTGE has been found to accelerate tyrosine hydroxylation in the striatal synaptosomes.