Publications by authors named "Shelly J Roberston"
Article Synopsis
- Trim7 is an E3 ubiquitin ligase that can influence host-viral interactions, showing both pro-viral and anti-viral roles in cell culture by targeting viral proteins for degradation.
- In a study involving two mouse lines lacking Trim7, researchers found no significant changes in viral load or tissue spread of murine norovirus (MNV) during infection, indicating that Trim7 may not play a crucial role in MNV infection in vivo.
- The investigation also showed that removing innate immune responses like STING and STAT1 did not uncover any regulatory function of Trim7 on MNV replication, suggesting that classifying Trim7 as a broad-spectrum antiviral may be misleading.
