Immunologic response to vaccine challenge in pregnant PTPN22 R620W carriers and non-carriers.

Objectives: Influenza infection is a significant cause of respiratory morbidity among pregnant women. Seasonal influenza vaccination engages innate immune receptors to promote protective immunity. A coding polymorphism (R620W) in PTPN22 imparts elevated risk for human infection and autoimmune disease, predisposes to diminished innate immune responses, and associates with reduced immunization responses.

Cervical Ectopic Pregnancy: Persistence Despite a Serologically Negative β-hCG. A Case Report.

Background: Cervical pregnancy is a rare type of ectopic pregnancy that can be associated with significant hemorrhage and loss of fertility. Given its rarity, most effective treatment protocols are not well established.

Case: A 33-year-old primigravid woman at 11 weeks' gestation presented to our institution with a cervical ectopic pregnancy with an initial β-hCG of 114,080 IU/L.