Publications by authors named "Shelly Dimri"
Mechanisms Regulating Mitochondrial Transfer in Human Corneal Epithelial Cells.
Invest Ophthalmol Vis Sci
November 2024
Purpose: The intraepithelial corneal nerves (ICNs) innervating the cornea are essential to corneal epithelial cell homeostasis. Rho-associated kinase (ROCK) inhibitors (RIs) have been reported to play roles in neuron survival after injury and in mitochondrial transfer between corneal epithelial cells. In this study, the mechanisms human corneal limbal epithelial (HCLE) cells use to control intercellular mitochondrial transfer are assessed.
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- The study investigates the role of rho kinase (ROCK) inhibitors in promoting the health of corneal nerves and their potential effect on nerve regeneration after injury.
- Researchers analyzed integrin and extracellular matrix expression in mouse neurons and explored how RI treatment influences neurite growth both in lab cultures and in live mice following injuries.
- Results showed that specific integrins were present on neuron growth structures, and RI treatment enhanced nerve growth in vitro and improved sensory nerve recovery in vivo after injury.
HIV-exposed seronegative individuals (HESIs) are a small fraction of persons who are multiply exposed to human immunodeficiency virus (HIV), but do not exhibit serological or clinical evidence of HIV infection. In other words, they are groups of people maintaining an uninfected status for a long time, even after being exposed to HIV several times. The long-term non-progressors (LTNPs), on the other hand, are a group of HIV-infected individuals (approx.
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