Rheological Properties, Dissolution Kinetics, and Ocular Pharmacokinetics of Loteprednol Etabonate (Submicron) Ophthalmic Gel 0.38.

To evaluate rheological properties, dissolution, and ocular pharmacokinetics of loteprednol etabonate (LE) (submicron) ophthalmic gel 0.38%. The viscosity of the LE gel 0.

Prolonged exposure to loteprednol etabonate in human tear fluid and rabbit ocular tissues following topical ocular administration of Lotemax gel, 0.5%.

Purpose: A new gel formulation containing loteprednol etabonate (LE), a C-20 ester corticosteroid used to treat ocular inflammation, was developed to provide increased retention on the ocular surface for improved drug delivery to intraocular tissues. This investigation evaluated concentrations of LE in tear fluid following topical instillation of LE gel to humans and the ocular and systemic pharmacokinetics of LE following administration to rabbits.

Methods: LE ophthalmic gel 0.

The use of the African green monkey as a preclinical model for ocular pharmacokinetic studies.

Purpose: This investigation evaluated the ocular and systemic pharmacokinetics of besifloxacin in African green monkeys compared with cynomolgus monkeys following topical ocular dosing.

Methods: A suspension formulation containing 0.6% besifloxacin was administered to African green and cynomolgus monkeys.