J Cardiothorac Vasc Anesth
February 2022
Objectives: The Coronavirus Disease 2019 (COVID-19) pandemic has been associated with cases of refractory acute respiratory distress syndrome (ARDS) sometimes requiring support with extracorporeal membrane oxygenation (ECMO). Bivalirudin can be used for anticoagulation in patients on ECMO support, but its efficacy and safety in patients with COVID-19 is unknown. The authors set out to compare the pharmacologic characteristics and dosing requirements of bivalirudin in patients requiring ECMO support for ARDS due to COVID-19 versus ARDS from other etiologies.
View Article and Find Full Text PDFJ Burn Care Res
October 2018
Hypothermia is a dangerous adverse effect that occurs in burn patients. Hypothermia leads to decreased renal blood flow and may decrease renal clearance of medications. Few human studies examine the effect of hypothermia on drug clearance and no known studies examine its effect on vancomycin clearance in burn patients.
View Article and Find Full Text PDFCancer Epidemiol Biomarkers Prev
July 2004
Vegetable consumption is associated with a reduced risk of colorectal cancer, which is the second most common cancer after lung/breast cancer within Europe. Some putative protective phytochemicals are found in higher amounts in young sprouts than in mature plants. The effect of an extract of mixed cruciferous and legume sprouts on DNA damage induced by H(2)O(2) was measured in HT29 cells using single cell microgelelectrophoresis (comet).
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