Publications by authors named "Shelley L Taylor"
Quantitative bioluminescence tomography using spectral derivative data.
Biomed Opt Express
September 2018
Article Synopsis
- Bioluminescence imaging (BLI) is an optical technique that measures light emitted from biological activity, often used in studies to track disease progression and develop treatments, particularly in cancer research.
- The goal of bioluminescence tomography (BLT) is to create accurate maps of light source distribution within the body, which requires overcoming challenges in light propagation modeling and detector optics.
- A new method introduced in this study utilizes the spectral derivative of BLI images to significantly reduce reconstruction errors, improving the accuracy of source intensity mapping from 49% to 4%.
Bioluminescence imaging is a noninvasive technique whereby surface weighted images of luminescent probes within animals are used to characterize cell count and function. Traditionally, data are collected over the entire emission spectrum of the source using no filters and are used to evaluate cell count/function over the entire spectrum. Alternatively, multispectral data over several wavelengths can be incorporated to perform tomographic reconstruction of source location and intensity.
View Article and Find Full Text PDFWe investigate the response to temperature of a well-known colloid-polymer mixture. At room temperature the gas-liquid critical value of the second virial coefficient of the effective pairwise colloid-colloid interaction for the Asakura-Oosawa model predicts the onset of gelation observed experimentally with remarkable accuracy. Upon cooling the system the effective attraction between colloids induced by polymer depletion is reduced, because the polymer radius of gyration decreases as the θ-temperature is approached.
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