Processing impairments in OCD: it is more than inhibition!

The study aimed to address a significant gap in the literature on inhibition impairments in OCD, by concurrently studying facilitation and inhibition processes and the effect of threat on these twin mechanisms. Participants were 20 persons with symptomatic OCD, 11 with remitted OCD, 20 with panic disorder and 20 normal control participants. Participants were required to respond to words that were either neutral or personally threatening, which during an immediately preceding trail, were responded to as targets (facilitation) or inhibited as non-targets (inhibition).

Executive functions in obsessive-compulsive disorder: state or trait deficits?

Objective: Despite the neuropsychology literature providing reliable evidence of impaired executive functions in obsessive-compulsive disorder (OCD), to date it has not been determined whether these deficits are trait-related (independent of symptomatology) or state-dependent (dependent on symptomatology). The current research examines the executive functions in OCD in a comprehensive manner and, for the first time, assesses the stability of these deficits over the developmental course of the disorder.

Method: Using a cross-sectional design, Study 1 examined the executive functions (set shifting, inhibition, planning, verbal fluency and working memory) in 60 subjects (20 actively Symptomatic OCD, 20 Remitted OCD and 20 Panic Disorder).

Response inhibition deficits in obsessive-compulsive disorder.

Difficulty inhibiting irrelevant information may play a central role in the aetiology of obsessive-compulsive disorder (OCD). The aim of the present study was to determine whether OCD subjects (n=20) exhibit deficits in behavioural and cognitive inhibition compared with a clinical control group diagnosed with panic disorder (n=20). All subjects were administered a Go/Nogo task (a measure of behavioural inhibition) and a Stroop test (a measure of cognitive inhibition).