Bhlhe40 limits early IL-10 production from CD4 T cells during 17X infection.

The cytokine IL-10 suppresses T-cell-mediated immunity, which is required to control infection with . Consequently, IL-10 can delay the time needed to resolve this infection, leading to a higher parasite burden. While the pathways that lead to IL-10 production by CD4 T cells are well defined, much less is known about the mediators that suppress the expression of this potent anti-inflammatory cytokine.