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Publications by authors named "Shelby Umland"

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Synopsis of recent research by authors named "Shelby Umland"

  • Recent research by Shelby Umland has focused on the development of potent TNF-α converting enzyme (TACE) inhibitors, specifically through the design of various hydantoin-based compounds that exhibit sub-nanomolar potency and favorable pharmacokinetic profiles.
  • Umland's work has addressed formulation challenges of lead compounds by exploring prodrug approaches, ultimately aiming to enhance their therapeutic viability for treating inflammatory diseases.
  • Additionally, Umland has contributed to the pharmacological characterization of various receptors, including the α2C-adrenoceptor and the role of ADAM family enzymes in immunological responses, demonstrating a broad interest in medicinal chemistry and receptor biology.

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