Publications by authors named "Shelby Chastain-Potts"
The emergence of a novel coronavirus, namely, SARS-CoV-2, necessitated the use of rapid, accurate diagnostics to quickly diagnose COVID-19. This need has increased with the emergence of new variants and continued waves of COVID-19 cases. The ID NOW COVID-19 assay is a rapid nucleic acid amplification test (NAAT) that is used by hospitals, urgent care facilities, medical clinics, and public health laboratories for rapid molecular SARS-CoV-2 testing at the point of care.
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- General anesthetics can harm brain development in young animals and humans, leading to cell death and lasting cognitive problems.
- The greatest risk occurs during intense brain development, particularly in areas like the subiculum, which affects learning and memory processes.
- In a study on rats and mice exposed to sevoflurane, researchers found that early anesthesia exposure resulted in changes to neuron structure and gene expression, affecting dendritic complexity and increasing spine density without altering the neuron's main body.
Large body of animal work and emerging clinical findings have suggested that early exposure to anesthetics may result in increased risk of learning disabilities and behavioral impairments. Recent studies have begun to investigate anesthesia-induced epigenetic modifications to elucidate their role in behavioral and neurodevelopmental abnormalities. Here we examine sevoflurane-induced transgenerational modifications of subicular neuronal DNA methylation and expression of immediate early genes (IEGs), arc and junB, crucial to synaptic plasticity and normal neuronal development.
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