Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab.

Background: IL-22 is potentially a pathogenic cytokine in patients with atopic dermatitis (AD), but the molecular effects of IL-22 antagonism have not been defined in human subjects.

Objective: We sought to evaluate the cellular and molecular effects of IL-22 blockade in tissues from patients with moderate-to-severe AD.

Methods: We assessed lesional and nonlesional skin from 59 patients with moderate-to-severe AD treated with anti-IL-22 (fezakinumab) versus placebo (2:1) using transcriptomic and immunohistochemistry analyses.

Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double-blind, phase 2a trial.

Background: Interleukin 22 promotes epidermal hyperplasia and inhibits skin barrier function.

Objective: Evaluate interleukin 22 blockade in adults with moderate-to-severe atopic dermatitis (AD).

Methods: We performed a randomized, double-blind, placebo-controlled trial with intravenous fezakinumab monotherapy every 2 weeks for 10 weeks, with follow-up assessments until 20 weeks.

Disseminated superficial actinic porokeratosis treated with ingenol mebutate gel 0.05.

Disseminated superficial actinic porokeratosis (DSAP) is a chronic condition characterized by numerous atrophic papules and patches with a distinctive peripheral keratotic ridge, typically found on sun-exposed areas. Treatment of DSAP is warranted not only for cosmetic and symptomatic benefits but also to prevent malignant transformation. Successful treatment of DSAP often is difficult and frequently requires the use of multiple modalities.

Relationship between severity of the local skin reactions and the rate of local skin reaction resolution in patients treated with ingenol mebutate gel.

Background: Ingenol mebutate gel is a topical field treatment for actinic keratosis (AK). The treatment elicits application-site reactions in most patients. This analysis evaluated the relationship between the severity of reactions and the speed of their resolution.

Reduced degree of irritation during a second cycle of ingenol mebutate gel 0.015% for the treatment of actinic keratosis.

Ingenol mebutate gel is a topical field treatment of actinic keratosis (AK). One of several proposed mechanisms of action for ingenol mebutate is induction of cell death in proliferating keratinocytes, suggesting a preferential action on AKs rather than healthy skin. Local skin reactions (LSRs) during 2 sequential 4-week cycles of AK treatment with ingenol mebutate gel 0.

Evaluating the Efficacy of Photodynamic Therapy with 20% Aminolevulinic Acid and Microdermabrasion as a Combination Treatment Regimen for Acne Scarring: A Split-face, Randomized, Double-blind Pilot Study.

Acne scarring is a consequence of abnormal resolution of wound healing after damage that occurs in the sebaceous follicle during acne inflammation. No trial to date has evaluated the efficacy of the combination of microdermabrasion and photodynamic therapy for acne scarring. This single-center, double-blinded pilot study enrolled subjects with moderate-to-severe acne scarring who were randomly assigned in a blinded fashion to use aminolevulinic acid and vehicle in a split-face fashion after full-face treatment with microdermabrasion.

Postoperative preferences in cutaneous surgery: a patient-centered investigation from an academic dermatologic surgery practice.

Background: Little is known about postoperative preferences regarding dermatologic surgery.

Objective: To determine patient preferences for postoperative follow-up after dermatologic surgery, desired follow-up interval, reasons for desired follow-up or lack thereof, and factors that may be associated with these preferences.

Materials And Methods: Patients who underwent Mohs micrographic surgery or excision within 24 months of Mohs micrographic surgery or excision were retrospectively surveyed regarding their postoperative follow-up preferences.

Separate- versus same-day preoperative consultation in dermatologic surgery: a patient-centered investigation in an academic practice.

Background: Little is known about patient preferences for preoperative consultation in dermatologic surgery.

Objective: To determine patient preferences for separate- versus same-day preoperative consultation and factors that may be associated with these preferences.

Methods And Materials: Patients who underwent Mohs micrographic surgery (MMS) or excision at our institution within 24 months were retrospectively surveyed regarding their preferences for a separate- or same-day preoperative consultation.