Publications by authors named "Sheku Koroma"
Background/objectives: Studies on uveitis in Sierra Leone were conducted prior to the Ebola Virus Disease epidemic of 2013-16, which was associated with uveitis in 20% of survivors. They did not include imaging or investigation of tuberculosis and used laboratory services outside the country. We performed a cross-sectional study on patients presenting with uveitis to establish their clinical characteristics and identify the impact of in-country laboratory diagnoses.
View Article and Find Full Text PDFBackground/objectives: Studies on uveitis in Sierra Leone were conducted prior to the Ebola Virus Disease epidemic of 2013-16, which was associated with uveitis in 20% of survivors. They did not include imaging or investigation of tuberculosis and used laboratory services outside the country. We performed a cross-sectional study on patients presenting with uveitis to establish their clinical characteristics and identify the impact of in-country laboratory diagnoses.
View Article and Find Full Text PDFThis study aimed to investigate the serological characteristics of Ebola virus (EBOV) infection during the late phase of the Ebola outbreak in Sierra Leone. In total, 877 blood samples from 694 suspected Ebola virus disease (EVD) cases assessed from March to December 2015, were analyzed via real-time reverse transcription polymerase chain reaction (RT-PCR) for viral RNA and enzyme-linked immunosorbent assay (ELISA) and Luminex to detect antibodies against EBOV. Viral load and EBOV-specific IgM/IgG titers displayed a declining trend during March to December 2015.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed data from 285 patients with confirmed Ebola virus disease (EVD) treated at Jui Government Hospital in Sierra Leone during the 2014-2015 outbreak, focusing on recovery and mortality rates.
- Out of the 285 patients, 146 recovered, leading to an overall survival rate of 51.23%, with very young children (under 6 years) having the lowest survival at 37.50%.
- Key factors that predicted poor outcomes included high blood viral load, confusion, abdominal pain, vomiting, and conjunctivitis, with most deaths occurring within the first week of hospitalization.
Article Synopsis
- A Chinese medical team treated 693 suspected Ebola patients in Sierra Leone from October 2014 to March 2015, confirming 288 cases of Ebola virus disease (EVD).
- A study of these 288 patients found that 98 died, 36 recovered, and 154 were lost to follow-up, with common symptoms including fever, fatigue, and diarrhea.
- Key factors linked to higher mortality included older age (particularly over 40) and a high viral load, with correlations identified between these factors and shorter survival times.
Background: The Ebola virus causes an acute, serious illness which is often fatal if untreated. However, factors affecting the survival of the disease remain unclear. Here, we investigated the prognostic factors of Ebola virus disease (EVD) through various statistical models.
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