[Parallel pharmacological correction of myocardial dysfunction, cognitive and psychopathological disordres in patients with congestive heart failure].

Was examined 92 patients with congestive heart failure III-IV FC with fraction of emission left ventricle < 45% against coronary artery disease. Patients of control group received basic therapy (according to recommendations of the Ukrainian society of cardiology), the 1 group--in addition received a preparation of Vazonat within 15 days intravenously in a dose of 1000 mg a day further are out-patient within 1 month on 250 mg 3 times per os; the 2 group--under the same scheme a preparation of Vazonat and a day tranquilizer of Adapto in a dose of 500 mg twice a day throughout all term of supervision. It is established that addition of Vazonat to basic treatment leads to additional effect concerning improvement of indicators cardio-hemodynamic, to improvement congestive functions.

[The effect of antioxidants and antihypoxants on the myoglobin content in patients with acute myocardial infarct].

A study of the content of myoglobin in the blood serum in 112 patients suffering of acute myocardial infarction showed the relationship between the reduction of this index and the kind of employed therapy (alpha-tocopherol, cytochrom-C, pyracetam). It was established inclusion of alpha-tocopherol in the treatment produced a most pronounced effect on normalization of the increased content of myoglobin.

[Cytochrome-C in the treatment of patients with acute myocardial infarct].

Sixty-eight patients with acute macrofocal myocardial infarction were subdivided in two groups depending on the kind of treatment: routine (nitrates, beta-blocking agents, calcium antagonists) and cytochrom-C. It was found that cytochrom-C produced a positive effect on the indices of myoglobin and cardiac fractions of lactatedehydrogenase-1 and lactatedehydrogenase-2. It is shown that inclusion of cytochrom-C during the first hours of treatment of patients with macrofocal myocardial infarction resulted in an improvement of tissue breathing and amelioration of the peri-infarction zone state.

[The effect of alpha-tocopherol on the hemodynamic indices of myocardial infarct patients].

Observation of groups of patients receiving traditional treatment and alpha-tocopherol indicates that inclusion of this agent in the treatment of patients suffering of myocardial infarction produced a favourable effect on normalization of the reduced stroke volume of the heart and increased peripheral resistance almost in the middle of the acute and beginning of the subacute periods.