Impact of resistant starch type 3 on fecal microbiota and stool frequency in Thai adults with chronic constipation randomized clinical trial.

Constipation poses a significant health concern affecting individuals of varying ages and geographic locations worldwide. While the impacts of numerous probiotics on constipation are well-characterized, there has been limited assessment of the potential prebiotic effects of resistant starches. We therefore conducted a randomized, double-blind and placebo-controlled, clinical trial of resistant starch type 3 (RS-3) in Thai adults with self-reported chronic constipation.

Novel intranasal phage-CaEDTA-ceftazidime/avibactam triple combination therapy demonstrates remarkable efficacy in treating Pseudomonas aeruginosa lung infection.

Given the rise of multidrug-resistant (MDR) Pseudomonas aeruginosa infections, alternative treatments are needed. Anti-pseudomonal phage therapy shows promise, but its clinical application is limited due to the development of resistance and a lack of biofilm penetration. Recently, adjuvants like CaEDTA have shown the ability to enhance the effectiveness of combined antimicrobial agents.

High prevalence of mgrB-mediated colistin resistance among carbapenem-resistant Klebsiella pneumoniae is associated with biofilm formation, and can be overcome by colistin-EDTA combination therapy.

The global prevalence of colistin-resistant Klebsiella pneumoniae (ColRkp) facilitated by chromosomal and plasmid-mediated Ara4N or PEtN-remodeled LPS alterations has steadily increased with increased colistin usage for treating carbapenem-resistant K. pneumoniae (CRkp). Our study demonstrated the rising trend of ColRkp showing extensively and pandrug-resistant characteristics among CRkp, with a prevalence of 28.

Novel colistin-EDTA combination for successful eradication of colistin-resistant Klebsiella pneumoniae catheter-related biofilm infections.

Development of an effective therapy to overcome colistin resistance in Klebsiella pneumoniae, a common pathogen causing catheter-related biofilm infections in vascular catheters, has become a serious therapeutic challenge that must be addressed urgently. Although colistin and EDTA have successful roles for eradicating biofilms, no in vitro and in vivo studies have investigated their efficacy in catheter-related biofilm infections of colistin-resistant K. pneumoniae.

Multidrug-resistant Neisseria gonorrhoeae infection in heterosexual men with reduced susceptibility to ceftriaxone, first report in Thailand.

The global rapid emergence of azithromycin/ceftriaxone resistant Neisseria gonorrhoeae threatens current recommend azithromycin/ceftriaxone dual therapy for gonorrhea to ensure effective treatment. Here, we identified the first two N. gonorrhoeae isolates with decreased ceftriaxone susceptibility in Thailand.

Interethnic differences in the prevalence of main cardiovascular pharmacogenetic biomarkers.

The aim of this study was to determine the prevalence of , , , , and genes polymorphisms among residents of the Volga region (Chuvash and Mari) and northern Caucasus (Kabardins and Ossetians). The study involved 845 apparently healthy volunteers of both sexes of the four different ethnic groups living in the Russian Federation: 238 from the Chuvash ethnic group, 206 Mari, 157 Kabardins and 244 Ossetians. Significant differences were identified in allele frequency of , , , , and genes polymorphisms between the Chuvash and Kabardins, Chuvash and Ossetians, Mari and Kabardians, Mari and Ossetians.

Recognition of 3'-end L1, Alu, processed pseudogenes, and mRNA stem-loops in the human genome using sequence-based and structure-based machine-learning models.

The role of 3'-end stem-loops in retrotransposition was experimentally demonstrated for transposons of various species, where LINE-SINE retrotransposons share the same 3'-end sequences, containing a stem-loop. We have discovered that 62-68% of processed pseduogenes and mRNAs also have 3'-end stem-loops. We investigated the properties of 3'-end stem-loops of human L1s, Alus, processed pseudogenes and mRNAs that do not share the same sequences, but all have 3'-end stem-loops.

[REACTIVITY AND RESISTANCE OF THE SPINAL STRUCTURES WHEN PERFORMING INSTRUMENTAL CORRECTION OF SPINAL DEFORMITIES].

The aim of the study was the electroneuromyographic evaluation of the spinal cord pyramidal structures reactivity and resistance in response to the impact of intraoperative factors associated with the application of technologies instrumental correction of spinal deformities of various etiologies and degrees of severity, realized with the help of submersible transpedicular fixation systems. Before treatment and 4-31 (9.6 ± 0.

Effect of Uranium and Thorium Radionuclides on Biochemical Characteristics of Duschekia fruticosa in "Soil-Plant" System.

The biochemical characteristics of Duschekiafruticosa, grown for a long time under a variety of exposure doses of natural background radiation (up to 150 μR/h) was studied. Uranium was found to make the dominant contribution to the y-background exposure doses. The pH-values and the content of organic matter in soils within the surveyed territory remained unchanged.

[ENMG-assessment of efficiency of temporal epidural electroneurostimulation in combined with robotic kinesotherapy in the treatment of patients with spinal cord injury consequences].

The goal of this study was to ENMG-assess effectiveness of the short combined neurorehabilitation course (temporal epidural stimulation of the spinal cord combined with a robotic kinesotherapy) in the restorative treatment of patients with traumatic spinal cord disease. Before and after completion of the combined instrumental neurorehabilitation (course duration--2-3 weeks) were tested 75 patients with spinal cord injury consequences. The authors used global and stimulation (H-reflex, M-response) electromyography methods.

[Efficacy of motor control at patients with cerebral hemiparesis in rehabilitation conditions with application of transosseous distraction cranio-osteosynthesis].

To study influence of transosseous distraction cranio-osteosynthesis on functional state of neuromotor system at patients with hemispheric stroke consequences, severe craniocerebral trauma analyzed dynamics of electroneuromyography index--cerebrospinal index, obtained by testing of extremities muscles at 28 persons in residual disease period. Data analysis obtained in control period testify to positive cerebrospinal index dynamics is maximum evident in long-term post-operative period and on leads from upper paretic limb. Thus, electrophysiologically identified increase of motor control efficacy of paretic limbs muscles at patients with cerebral alteration consequences in treatment by transosseous distraction cranio-osteosynthesis.

[Neurophysiological correlates of pyramidal insufficiency of ischemic and traumatic genesis in conditions of distraction osteosynthesis application].

Analyzed main trends in variations of quantitative electroneuromyographic characteristics at patients with stroke and severe craniocerebral trauma consequences in the treatment process using transosseous distraction osteosynthesis. Studied specific features of central nervous system reaction on present surgical treatment at patients depending on age, etiology and severity of initial brain structures damage. Formulated notions about staging and mechanisms of reactive change in the brain-cortex under the influence of rehabilitation by transosseous distraction osteosynthesis at patients of noted nosological groups.

[Micropulse 577 nm laser trabeculoplasty--a prospective pilot study].

Purpose: To evaluate the efficacy of micropulse 577 nm laser trabeculoplasty.

Material And Methods: Prospective clinical trial designed for 30 patients diagnosed with open angle glaucoma. The micropulse 577 nm laser trabeculoplasty was performed in one eye of each patient in the lower half of trabecular meshwork.

[Voluntary control of lengthened and intact limbs muscles tension under different force load ranges].

The data are presented which supporting the hypothesis of the presence of isometric force load zone, within which the subjects tested organize the voluntary muscle tension controlling with maximal accuracy and minimal specific power expenses, estimated indirectly, by the ratio of the surface electromyogram (EMG) area (integral of EMG) to force moment impulse. The asymmetries of the integral values of visual-and-motor tracking have been analyzed as well using isometric control organs in 23 patients at the age of 15-35 years (6 - males and 17 - females) in different periods after surgical elimination of lower limb length discrepancies. Poorly marked zone of minimization of integral discrete visual-and-motor tracking estimates, manifesting itself within 25-35% of the maximal force of the muscle group tested (foot dorsal flexors) has been noted in tested healthy subjects (26 normal males at the age of 19-39 years) and orthopedic patients (intact limb).

[The functional status of the cerebral cortex after replacement of skull base bone defects].

The functional status of the cerebral cortex was evaluated by EEG before and different periods after prolonged cranial osteoplasty made by the type of replacement of skull base bone defects in patients with dyscirculatory encephalopathies of various genesis. Seven patients aged 20 to 50 years undergone repair of skull base bone defects (both posttraumatic and simulated) by the procedures developed at the Russian Research Center "VTO" were examined. The bioelectrical activity of the brain was recorded and analyzed on a PEGASUS digital 16-channel EEG system (EMS, Austria) by using the Fourie prompt conversion test (spectral analysis) and amplitude-frequency mapping.