Publications by authors named "Sheila Sharifi"
Mohs micrographic surgery (MMS) is a highly effective treatment for skin cancers, such as squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), especially in cosmetically sensitive areas. Despite its high cure rates, the procedure's impact on psychosocial outcomes, influenced by demographic, clinical, psychological, and social factors, necessitates careful consideration. This review aims to identify and synthesize the predictors of psychosocial outcomes following MMS, thereby informing patient management strategies.
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- Facioscapulohumeral dystrophy (FSHD) is caused by the contraction of D4Z4 repeats on chromosome 4q, affecting gene regulation due to mutations that serve as disease modifiers.
- The condition is characterized by disruption of heterochromatin and abnormal expression of the DUX4 transcription factor, but understanding this process has been complicated by genetic variability in patient muscle cells.
- This study developed isogenic cell lines to show how mutations influence D4Z4 heterochromatin differently, stabilizing DUX4 activation and revealing how it contributes to FSHD through downstream targets.