The Effects of Thymoquinone Loaded in Alginate Scaffold on Bone Regeneration in Rabbit Mandible Defect.

Background: Thymoquinone (TQ) has some beneficial roles in bone repair. Local administration of the drugs by loading them into a scaffold leads to releasing higher concentrations of a drug in the appropriate position. This study was conducted to evaluate the effects of the local administration of TQ loaded in an alginate scaffold on bone regeneration in rabbit mandibular defect.

Clinical evaluation of marginal fit of uncemented CAD-CAM monolithic zirconia three-unit restorations in anterior areas, using scannable and conventional polyvinyl siloxane impression materials.

Background: The accuracy of impression techniques determines the marginal fit of fixed prostheses. Marginal accuracy plays a main role in the success and failure of treatments. This in-vivo study evaluated the marginal fit of anterior three-unit monolithic zirconia fixed partial dentures (FPDs) using conventional and scannable polyvinyl siloxane impression materials.

Evaluation of the Possible Synergic Regenerative Effects of Platelet-Rich Plasma and Hydroxyapatite/Zirconia in the Rabbit Mandible Defect Model.

Background: Platelet-rich plasma (PRP) and bioceramics such as hydroxyapatite (HA) and zirconium oxide (ZrO) are used to reconstruct mandibular defects. We sought to determine the synergistic effects of HA/ZrO and PRP and compare their osteogenic activity.

Methods: ZrO scaffolds were constructed by the slurry method and were then coated with HA and impregnated by PRP/heparan sulfate (HS).