Precut Post-Laser In Situ Keratomileusis / Photorefractive Keratectomy Donor Corneas for Use in Endothelial Keratoplasty: Potential Impact of Postcut Morphology on Visual Outcomes.

Purpose: To evaluate the accuracy, complication rates, cut quality, and degree of induced hyperopic shift of eye bank-prepared post-laser in situ keratomileusis (LASIK)/photorefractive keratectomy (PRK) donor corneas compared to those of non-post-LASIK/PRK donor corneas.

Methods: The cut accuracy and failure rates of all post-LASIK/PRK donor cornea tissue processed for use in Descemet stripping automated endothelial keratoplasty (DSAEK) from January 2012 through December 2016 were compared to control cornea donor tissue. Corneas were analyzed for regularity and morphology of cut using anterior segment optical coherence tomography images.

Overview of Systemic Candida Infections in Hospital Settings and Report of Candida After DMEK Successfully Treated With Antifungals and Partial Graft Excision.

Purpose: To report novel surgical and medical management of intraocular and corneal infection with Candida glabrata that manifested 3 months after Descemet membrane endothelial keratoplasty (DMEK) and to review demographic reasons for increasing fungal contamination of donor tissue.

Methods: Demographics, donor rim cultures, diagnostic tests, management, clinical course, outcomes, and donor mate outcomes are reported for a fungal infection after DMEK.

Results: The fungal infection was treated for 3 weeks with a combination of intracameral and intracorneal voriconazole and intracameral and topical amphotericin B (off-label use).

Systemic Fungal Infections in Donors for Corneal Transplantation.

Purpose: To determine the prevalence of postkeratoplasty fungal infection when corneal tissue from donors with a recent medical history of oral thrush or respiratory, urine, wound, sputum, bronchial, tracheal, or throat culture positive for fungus is identified before recovery and after decontamination of the corneal tissue with 5% povidone-iodine flush to the donors' eyes during recovery.

Methods: This is a prospective analysis of corneas from 42 donors with a documented medical history of fungus or positive fungal culture, which were recovered between January 2010 and November 2010. Standard aseptic swab of the donors' corneas before and after application of 5% povidone-iodine solution was performed.

Amaurosis fugax due to pleomorphic sarcoma in the left atrium.

Purpose: This report describes a case of amaurosis fugax due to a rare primary cardiac sarcoma.

Observations: A patient who was recently diagnosed with left atrial pleomorphic sarcoma presented with a chief complaint of multiple episodes of intermittent vision loss in the right eye during the course of radiation therapy.

Conclusions And Importance: The authors postulate emboli from the left atrial sarcoma entered systemic circulation and subsequently caused brief episodes of transient occlusion to retinal, ophthalmic and/or ciliary arteries leading to momentary retinal hypoxia.

The presentation and clinical significance of sinonasal respiratory epithelial adenomatoid hamartoma (REAH).

Background: Sinonasal respiratory epithelial adenomatoid hamartoma (REAH) is a benign glandular proliferation with ciliated epithelium. Little is known about REAH, with only a few published case reports appearing since its original description in 1995. Classically described as an isolated polypoid lesion arising from the nasal septum, more recent descriptions also suggest that REAH can occur among nasal polyps.

Exploring the clinical value and implications of routine pathological examination of septoplasty specimens.

Objectives/hypothesis: During septoplasty, otherwise normal cartilage and bone are removed and routinely submitted for pathologic examination. According to the College of American Pathologists, however, the examination of bone and cartilage from septoplasty and rhinoplasty may be left to the pathologist's discretion. We explored the processing of tissues removed during septoplasty, examining the clinical value and implications of current practices.

Management of radiation maculopathy.

Radiation maculopathy is a delayed onset complication of radiation exposure. Various host and radiation parameters determine the risk of developing radiation maculopathy, which may be progressive. Total radiation dose delivered to the macula is the most important modifiable factor.

Eicosanoid signaling and vascular dysfunction: methylmercury-induced phospholipase D activation in vascular endothelial cells.

Mercury, especially methylmercury (MeHg), is implicated in the etiology of cardiovascular diseases. Earlier, we have reported that MeHg induces phospholipase D (PLD) activation through oxidative stress and thiol-redox alteration. Hence, we investigated the mechanism of the MeHg-induced PLD activation through the upstream regulation by phospholipase A2 (PLA2) and lipid oxygenases such as cyclooxygenase (COX) and lipoxygenase (LOX) in the bovine pulmonary artery endothelial cells (BPAECs).