Publications by authors named "Sheila Oliveira"
Article Synopsis
- The study aimed to assess disease activity, muscle strength, and functional abilities in newly diagnosed juvenile dermatomyositis (JDM) patients over a 2-year period.
- A total of 96 JDM patients were evaluated at diagnosis and at 6, 12, 18, and 24 months using various clinical assessment tools, showing significant improvements in some areas, particularly in the first 6 months.
- Despite overall improvement in disease activity scores, some measures like childhood myositis and disability indices showed no significant progress, indicating ongoing functional impairment.
Article Synopsis
- Streptococcus pneumoniae is a harmful bacterium that causes over one million deaths each year and often infects people, especially young kids, without showing symptoms at first.
- It can become dangerous when conditions change, like during a viral infection, allowing it to cause serious illness.
- The study focused on understanding how a special transporter, PotABCD, helps the bacteria form biofilms, which are protective layers that keep them alive; more polyamines (a type of chemical) in their environment made it easier for the bacteria to form these biofilms, especially in complex settings.
Article Synopsis
- The study aimed to investigate if patients with systemic juvenile idiopathic arthritis (sJIA) have a higher occurrence of rare genetic variants associated with hemophagocytic lymphohistiocytosis (HLH) compared to controls.
- Researchers performed targeted sequencing on key HLH-related genes in sJIA patients and compared results against a large control group, finding significant associations with rare variants, particularly in the STXBP2 and UNC13D genes.
- The results suggest that rare HLH variants may play a role in the development of sJIA, with distinct patterns observed in patients with and without macrophage activation syndrome (MAS), indicating a complex genetic influence on the condition.
Objective: To evaluate whether there is an enrichment of rare variants in familial hemophagocytic lymphohistiocytosis (HLH) genes and systemic juvenile idiopathic arthritis (sJIA) with or without macrophage activation syndrome (MAS).
Methods: Targeted sequencing of HLH genes (, , , , , ) was performed in sJIA subjects from an established cohort. Sequence data from control subjects were obtained (dbGaP:phs000280.
Prevalence of psychological and mental health symptoms among nursing professionals during the COVID-19 pandemic in the Americas: Systematic review and meta-analysis.
Int J Ment Health Nurs
June 2024
To assess the prevalence of mental health symptoms in nursing professionals during the COVID-19 pandemic on the American continent. A systematic review and meta-analysis of observational studies that estimated the prevalence of mental health symptoms in nursing professionals during the COVID-19 pandemic was performed through bibliographic database searches. A three-level meta-analysis model was used with the inverse variance method, tau was estimated via restricted maximum likelihood and logistic transformation, and heterogeneity was presented as tau and I.
View Article and Find Full Text PDFDespite the implementation of conjugate vaccines in several countries, S. pneumoniae continues to pose a great burden worldwide, causing around 1 million annual deaths. Pneumococcal proteins have long been investigated as serotype-independent vaccines against this pathogen, with promising results.
View Article and Find Full Text PDFCachaça is a Brazilian beverage obtained from the fermentation of sugarcane juice (sugarcane spirit) and is considered one of the most consumed alcoholic beverages in the world with a strong economic impact on the northeastern Brazil, more specifically in the Brejo. This microregion produces sugarcane spirits with high quality associated to edaphoclimatic conditions. In this sense, analysis for sample authentication and quality control that uses solvent-free, environmentally friendly, rapid and non-destructive methods is advantageous for cachaça producers and production chain.
View Article and Find Full Text PDFObjective: (1) A remote intervention with a positive impact on reducing anxiety and alcohol use. (2) Nursing as a protagonist of preventive care in mental health (3) A low-cost intervention that covers several population groups. (4) Telenursing in mental health as a care strategy during COVID-19.
View Article and Find Full Text PDFBackground: Surgical glue has been used in several body tissues, including perineal repair, and can benefit women.
Objectives: To evaluate the effectiveness of n-butyl-2-cyanoacrylate surgical glue compared to the polyglactin 910 suture in repairing first- and second-degree perineal tears and episiotomy in vaginal births.
Design: A parallel randomised controlled open trial.
IMPACTO-MR: a Brazilian nationwide platform study to assess infections and multidrug resistance in intensive care units.
Rev Bras Ter Intensiva
March 2023
Objective: To describe the IMPACTO-MR, a Brazilian nationwide intensive care unit platform study focused on the impact of health care-associated infections due to multidrug-resistant bacteria.
Methods: We described the IMPACTO-MR platform, its development, criteria for intensive care unit selection, characterization of core data collection, objectives, and future research projects to be held within the platform.
Results: The core data were collected using the Epimed Monitor System® and consisted of demographic data, comorbidity data, functional status, clinical scores, admission diagnosis and secondary diagnoses, laboratory, clinical, and microbiological data, and organ support during intensive care unit stay, among others.
Sociodemographic and clinical variables as determinants of mortality and survival in patients with acute ST-elevation myocardial infarction in the Eastern Amazon.
J Public Health Res
January 2023
Background: The aim of this study was to analyze the influence of sociodemographic and clinical variables as determinants of mortality and survival in patients with ST-segment elevation acute myocardial infarction in the Eastern Amazon.
Design And Methods: This observational, longitudinal, and retrospective study was conducted at the Gaspar Vianna Clinical Hospital Foundation in patients hospitalized from January 2017 to June 2020. Patients were divided into two groups: those who survived (G1) ( = 646) and those who died (G2) ( = 37).
Background: Rheumatic diseases are associated with an increase in overall risks of tuberculosis (TB). The aim of this study was to evaluate the frequency of TB and the frequency of latent TB infection (LTBI), in clinical practice, for juvenile idiopathic arthritis (JIA) patients from high and low risk of TB incidence endemic countries.
Methods: This is an international, multicenter, cross-sectional, observational study of data collection from Brazil and Registry of Portugal at REUMA.
Article Synopsis
- * Antimicrobial peptides (AMPs) like indolicidin, produced by the immune system, show bactericidal effects against various bacteria, but their effectiveness can be compromised by the pneumococcal capsule.
- * Research found that different pneumococcal serotypes showed varying resistance to indolicidin based on the capsule's characteristics, suggesting that polysaccharide-based vaccines might enhance the effectiveness of AMPs in fighting pneumonia.
In March 2020, physical distancing and quarantine measures were implemented in Brazil, which may have affected the physical and mental health of the population. This cross-sectional study used a convenience sample and telephone-based interviews to identify anxiety symptoms and alcohol use patterns among 1,264 Brazilian primary health care (PHC) patients during the COVID-19 pandemic. The State-Trait Anxiety Inventory-State 6 and Alcohol Use Disorders Identification Test (AUDIT-C) questionnaires were used to assess anxiety symptoms and alcohol use patterns, respectively.
View Article and Find Full Text PDFObjective: The aim of this work was to provide evidence of validity and reliability for 4 parent/child-reported outcome measures included in the Outcome Measures in Rheumatology juvenile idiopathic arthritis core domain set: the evaluation of the child's pain and level of disease activity, the assessment of morning stiffness duration, and an active joint count for proxy/self-assessment.
Methods: Patients were included in the multinational study Epidemiology Treatment and Outcome of Childhood Arthritis. Criterion validity was assessed by examining the correlation of the 4 tested measures with physician measures and the clinical Juvenile Arthritis Disease Activity Score in 10 joints (cJADAS10) in the whole sample and after grouping patients by International League of Associations for Rheumatology (ILAR) category, geographic area, and education level.
Strategies Adopted by Addiction Facilities during the Coronavirus Pandemic to Support Treatment for Individuals in Recovery or Struggling with a Substance Use Disorder: A Scoping Review.
Int J Environ Res Public Health
November 2021
This review aimed to identify and synthesize strategies and actions adopted by addiction facilities to support and maintain treatment during the coronavirus disease 2019 (COVID-19) pandemic. A scoping review was conducted using the following information sources: Virtual Health Library, SCOPUS, Web of Science, PubMed, CINAHL, and Latin American and Caribbean Health Science Literature. From a total of 971 articles, 28 studies were included.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to identify risk factors for Inflammatory Bowel Disease (IBD) in children with Juvenile Idiopathic Arthritis (JIA) by analyzing data from the Pharmachild register and comparing characteristics of patients with and without IBD.
- - Out of 8,942 JIA patients, only 48 (0.54%) developed IBD, with notable differences in demographics such as being predominantly male, older at diagnosis, more likely to have a family history of autoimmune conditions, and more often associated with enthesitis-related arthritis.
- - Key predictors for developing IBD included having enthesitis-related arthritis and a family history of autoimmune disease, while certain therapies like etanercept were linked to significantly higher rates
Background: Resilience is a dynamic process influenced by life circumstances. This study evaluated the association between resilience and anxiety, depressive symptoms, and quality of life (QoL) of mothers of children with congenital Zika syndrome (CZS).
Method: This was a cross-sectional study including 31 mothers of children with CZS assisted in rehabilitation centers in Sergipe state, Northeast Brazil, an endemic area for Zika virus (ZIKV).
Safety and immunogenicity of the quadrivalent human papillomavirus vaccine in patients with juvenile dermatomyositis: a real-world multicentre study.
Pediatr Rheumatol Online J
November 2020
Background: Concerns about the safety and efficacy of vaccines in patients with autoimmune diseases (AID) have led to contradictions and low vaccination coverage in this population, who are at a higher risk of infections, including by human papillomavirus (HPV). Although HPV vaccines have been recommended for immunocompromised patients, there is still a lack of data to support its use for AID patients, such as juvenile dermatomyositis (JDM) patients. The aim of this study was to assess the safety and immunogenicity of the quadrivalent HPV (qHPV) vaccine in a cohort of JDM patients.
View Article and Find Full Text PDFObjective: To assess childhood-onset systemic lupus erythematosus-related antiphospholipid syndrome(cSLE-APS) in a large Brazilian population.
Methods: A retrospective observational cohort study was carried-out in 27 Pediatric Rheumatology university centers, including 1519 cSLE patients.
Results: cSLE-APS was observed in 67/1519 (4%) and was diagnosed at disease onset in 39/67 (58%).