Background: Xanthine oxidase inhibitors (XOI), classified as purine-like (allopurinol and oxypurinol) and non-purine (febuxostat and topiroxostat) XOI, present antioxidant properties by reducing the production of reactive oxygen species derived from purine metabolism. Oxidative stress is an important factor related to endothelial dysfunction and ischemia-reperfusion injury, and may be implicated in the pathogenesis of heart failure, hypertension, and ischemic heart disease. However, there is contradictory evidence regarding the possible cardiovascular (CV) protective effect exerted by XOI.
View Article and Find Full Text PDFAims And Objectives: To determine the reliability and internal consistency of a questionnaire that was designed to assess weight cycling.
Background: A large part of the obese population attempt to lose weight. Of those who had lost at least 10% of their initial weight, 33·5% regained weight.