Exploring the conformations of nitric oxide synthase with fluorescence.

Multi-domain oxidoreductases are a family of enzymes that catalyze oxidation-reduction reactions through a series of electron transfers. Efficient electron transfer requires a sequence of protein conformations that position electron donor and acceptor domains in close proximity to each other so that electron transfer can occur efficiently. An example is mammalian nitric oxide synthase (NOS), which consists of an N-terminal oxygenase domain containing heme and a C-terminal reductase domain containing NADPH/FAD and FMN subdomains.

Decisions and delays within stroke patients' route to the hospital: a qualitative study.

Study Objective: We examine acute stroke patients' decisions and delays en route to the hospital after onset of symptoms.

Methods: This was a qualitative study carried out in the West Midlands, United Kingdom. Semistructured interviews were conducted with 30 patients (6 accompanied by partners).

Protocol for an observation and implementation study investigating optimisation of the management of stroke and transient ischaemic attack (TIA).

Introduction: Patients benefit from early and intensive treatment in both acute ischaemic stroke and transient ischaemic attack. Recent audits of acute stroke/transient ischaemic attack care suggest that although standards have improved, current services still fall short of optimal care. The aim of this study is to establish a database of patients accessing stroke services.

Congratulations on conference success.

On behalf of the RCN Ethics Forum, I would like to congratulate the Isle of Man Branch on the success of its recent three-day conference on the value of nursing.