Comparison of periapical parallel radiography with cbct with different field of views (FOV) for the detection of periapical lesions.

Background: Chronic apical periodontitis (AP) may influence the outcome of root canal treatment. Thus, it is important to diagnose AP using the best method available. This research was done to compare the diagnostic accuracy of parallel periapical radiography (PR) and different field of views (FOVs) of cone-beam computed tomography (CBCT).

Fibroblast growth factor receptor 1 gene (FGFR1) amplification in non-small cell lung cancer (NSCLC) by real-time PCR.

Background: Comprehensive molecular assessment of cancers could open up new horizons for novel therapies. Fibroblast growth factor receptor 1 (FGFR1) gene amplification has been previously demonstrated in non-small cell lung cancer (NSCLC) patients. The current study aimed to evaluate the prevalence of FGFR1 gene amplification and its association with clinical and demographic data in a group of NSCLC patients.

The enhancement of teacher immunity in a professional development course: Contributions from supervisory observation and the observer.

Classroom observation has been reported to be stressful for language teachers since it can disrupt the equilibrium and push the teachers towards maladaptive language teacher immunity. The present study is an attempt to shed light on the way classroom observation and a professional development (PD) course on classroom observation contribute to language teacher immunity development through self-organization lens. To this end, the researchers in the current study designed an explanatory sequential mixed method study and 13 novice language teachers were invited to fill language teacher immunity scale before and after a professional development course.

Activation of muscle amine functional groups using eutectic mixture to enhance tissue adhesiveness of injectable, conductive and therapeutic granular hydrogel for diabetic ulcer regeneration.

Herein, Polydopamine-modified microgels and microgels incorporated with superficial epoxy groups were synthesized and applied as precursors for the fabrication of four granular hydrogels. To enhance the tissue adhesiveness, a ternary deep eutectic solvent was synthesized to activate the muscle amine functional groups facilitating the formation of robust NC bonds at ambient conditions. At a certain shear rate of 10 s, hydrogel DMG displayed a viscosity of 9×10 Pa/s, representing the highest complex viscosity among the tested hydrogels primarily driven by quinone groups in PDA which enhanced reversible interactions, thereby increasing particle cohesion.

First report of fesavirus 4 detection from cats in Japan.

Fesaviruses, picorna-like RNA viruses, were discovered in 2014 in feces from cats in an animal shelter in the United States but have not since been reported elsewhere. In this study, we collected cat fecal samples from 20 adult cats from an animal shelter in Tokyo, Japan, and examined them for viral pathogens. Next generation sequencing (NGS) was performed to detect both RNA and DNA virus sequences.

Impact of sarcopenia on clinical outcomes in pediatric chronic liver disease post-liver transplantation: prevalence and implications.

Aim: The purpose of this retrospective single-center study was to determine the frequency of sarcopenia and its association with mortality and other morbidities in children with chronic liver disease who had undergone liver transplantation.

Background: Sarcopenia, a muscle-wasting syndrome, is common in patients with advanced liver disease and is associated with increased morbidity and mortality. While sarcopenia in adults has been extensively studied, there is little information in this regard about children and adolescents with chronic liver diseases.

Prognostic significance of ASXL1 mutations in acute myeloid leukemia: A systematic review and meta-analysis.

Background: Although genetic mutations in additional sex-combs-like 1 (ASXL1) are prevalent in acute myeloid leukemia (AML), their exact impact on the AML prognosis remains uncertain. Hence, the present article was carried out to explore the prognostic importance of ASXL1 mutations in AML.

Methods: We thoroughly searched electronic scientific databases to find eligible papers.

A bi-functional nanofibrous composite membrane for wound healing applications.

Various wound dressings have been developed so far for wound healing, but most of them are ineffective in properly reestablishing the skin's structure, which increases infection risks and dehydration. Electrospun membranes are particularly interesting for wound dressing applications because they mimic the extracellular matrix of healthy skin. In this study, a potential wound healing platform capable of inducing synergistic antibacterial and antioxidation activities was developed by incorporating bio-active rosmarinic acid-hydroxyapatite hybrid (HAP-RA) with different contents (0.

Comparison of Antimicrobial Effects of 445 and 970 nm Diode Laser Irradiation with Photodynamic Therapy and Triple Antibiotic Paste on in the Root Canal: an Study.

Colonization of residual organisms in the root canal are major causes of root canal treatment failure. Therefore, the effective removal of organisms during root canal cleaning stages is of great importance. In this study, we aimed to investigate and compare the antimicrobial effects of several methods including high power laser irradiation, photodynamic therapy and triple antibiotic paste (TAP) on in the root canal.

Protein C and S activities in COVID-19: A systematic review and meta-analysis.

COVID-19 has been associated with alterations in coagulation. Recent reports have shown that protein C and S activities are altered in COVID-19. This may affect the complications and outcome of the disease.

Myeloid sarcoma in brain and optic nerve presented as a relapse of acute myeloid leukemia: A case report.

Myeloid sarcoma (MS) is a rare extramedullary infiltration of acute myeloid leukemia (AML). We present a case of 19-year-old male with AML-M2 who relapse with AML sarcoma in brain and optic nerve. MS as AML extramedullary relapse had a poor prognosis.

Peptide Acylation in Aliphatic Polyesters: a Review of Mechanisms and Inhibition Strategies.

Biodegradable polyesters are widely employed in the development of controlled release systems for peptide drugs. However, one of the challenges in developing a polyester-based delivery system for peptides is the acylation reaction between peptides and polymers. Peptide acylation is an important factor that affects formulation stability and can occur during storage, in vitro release, and after drug administration.

Asymptomatic Urinary Tract Infection Treatment in Adults Admitted to Inpatient Psychiatry: A Retrospective COHORT study.

Treatment of asymptomatic bacteriuria remains prevalent despite recommendations against treatment in most patient populations. Rates of asymptomatic treatment of urinary tract infection (UTI) has not been thoroughly evaluated within the inpatient psychiatry population. The objective of this study is to describe the rate of antibiotic use for the treatment of asymptomatic UTI in psychiatric inpatients and investigate factors contributing to overuse.

Force attenuation performance in sandwich structures with STF and M-STF encapsulation.

In this study, we investigate the role of adding shear thickening fluids (STFs) and multi-functional shear thickening fluids (M-STFs) to the core of a sandwich-structured composite made of aluminum facesheets and XPS foam cores with different geometries on force attenuation performance. Six different core designs were machined, and all designs had the same space for adding STFs and M-STFs. STF with 40 wt% SiO in PEG 400 was selected and fabricated.

Thermodynamics, Environmental and Sustainability Impacts of a Turbofan Engine Under Different Design Conditions Considering Variable Needs in the Aviation Industry.

In this study, thermodynamic analysis is implemented to the kerosene-fuelled high by-pass turbofan (HBP-TF) engine to assess entropy, exergy, environmental, and sustainability metrics for different design variables such as pressure ratio of high-pressure compressor (HPC-PR) ranging from 7.5 to 8.5 and turbine inlet temperature (TIT) varying from 1400 to 1525 K considering variable needs in the aviation industry.

A high loading nanocarrier for the 5-fluorouracil anticancer drug based on chloromethylated graphene.

In the present work, we report a facile and simple strategy to functionalize graphene with the chloromethyl (CHCl) functional group as a nanoplatform for effectual loading of the 5-fluorouracil (5-FU) anticancer drug. To achieve the highest loading capacity, hydrochloric acid concentration, the quantity of paraformaldehyde, ultrasonic treatment time, and stirring duration were all carefully optimized. The results revealed that the optimum conditions for functionalizing graphene were obtained at 70 mL of hydrochloric acid, 700 mg of paraformaldehyde, and times of 35 min and 2 h of ultrasonication and stirring.

Electrospun nylon 6/hyaluronic acid/chitosan bioactive nanofibrous composite as a potential antibacterial wound dressing.

Hyaluronic acid (HA) and chitosan (CS), as natural biomaterials, display excellent biocompatibility and stimulate the growth and proliferation of fibroblasts. Furthermore, nylon 6 (N6) is a low-cost polymer with good compatibility with human tissues and high mechanical stability. In this study, HA and CS were applied to modify N6 nanofibrous mat (N6/HA/CS) for potential wound dressing.

Evaluation of the expression of LC3-II and BECLIN1 genes of autophagy pathway in patients with hematological malignancies.

Background: Autophagy is a pathway for the degradation of cytoplasmic components, which plays an essential role in various cellular and physiological processes, including cell renewal and survival, and immune responses. While recent studies have shown that they can play a role in cancer treatment, the precise mechanisms of autophagy in leukemogenesis are not fully understood. We have assessed the expression levels of LC3 and BECLIN1 as two crucial autophagy mediators in patients with leukemia.

Deep-learned generation of renal dual-energy CT from a single-energy scan.

Aim: To investigate the role of the deep-learning (DL) method in the generation of dual-energy computed tomography (DECT) images from single-energy images for precise diagnosis of kidney stone type.

Materials And Methods: DECT of 23 patients was acquired, and the stone types were investigated based on the DECT software suggestions. The data were divided into two paired groups:120 kVp input and 80 kVp target and 120 kVp input and 135 kVp targets, p2p-UNet-GAN was exploited to generate the different energy images based on the common CT protocols.

Contemporaneous SARS-CoV-2-Neutralizing Antibodies Mediated by N-glycan Shields.

Mutations and the glycosylation of epitopes can convert immunogenic epitopes into non-immunogenic ones via natural selection or evolutionary pressure, thereby decreasing their sensitivity to neutralizing antibodies. Based on Thomas Francis's theory, memory B and T cells induced during primary infections or vaccination will freeze the new mutated epitopes specific to naïve B and T cells from the repertoire. On this basis, some researchers argue that the current vaccines derived from the previous strains of the SARS-CoV-2 virus do not increase immunity and may also prevent the immune response against new epitopes.

Design of experiments approach for the development of a validated method to determine the exenatide content in poly(lactide-co-glycolide) microspheres.

Due to the lack of pharmacopeia guidelines for injectable microspheres based on poly (D, L-lactide-co-glycolide) (PLGA), an internal method validation is a critical prerequisite for quality assurance. One of the essential issues of developing peptide-based drugs loaded PLGA microspheres is the precise determination of the amount of peptide drug entrapped in the microspheres. The aim of this study is the development and optimization of a method for measuring the drug content loading of PLGA microspheres using exenatide as a model peptide drug.

Recent progress in the intranasal PLGA-based drug delivery for neurodegenerative diseases treatment.

One of the most challenging problems of the current treatments of neurodegenerative diseases is related to the permeation and access of most therapeutic agents to the central nervous system (CNS), prevented by the blood-brain barrier (BBB). Recently, intranasal (IN) delivery has opened new prospects because it directly delivers drugs for neurological diseases into the brain via the olfactory route. Recently, PLGA-based nanocarriers have attracted a lot of interest for IN delivery of drugs.

The correlation between humoral immune responses and severity of clinical symptoms in COVID-19 patients.

The SARS-CoV-2 pandemic persists with global repercussions. Initial COVID-19 symptoms encompass pneumonia, fever, myalgia, and fatigue. The human immune system produces IgM and IgG antibodies in response to SARS-CoV-2.

Evaluation of the effect of direct sinus lift surgery on maxillary sinus volume by Mimics software.

Introduction: Sinus lift surgery allows sufficient volume of bone to be created in the posterior part of the maxilla. The aim of this study was to investigate the changes in maxillary sinus volume after a sinus lift and the rate of increase in ridge height at the site of the graft.

Methods: Eleven patients were chosen for sinus lift from among those who were referred to the radiology department for implant placement in the posterior region of the maxilla and whose bone height at the posterior of the maxilla was less than 4 mm on the cone-beam computed tomography (CBCT) image.