Publications by authors named "Sheikh R"

Trade unions and corporate social responsibility (CSR) are important institutional mechanisms through which corporations undertake responsibility for their for-profit as well as not-for-profit actions. This study explores the roles of trade unions, management, and shareholders in influencing environmental, social, and governance (ESG) controversies and CSR reporting. Drawing on instrumental stakeholder theory, we argue that while management and shareholders typically focus on governance, profitability, and operational efficiency, trade unions act as critical relational stakeholders advocating for employee welfare and social sustainability.

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Introduction: Lower urinary tract symptoms (LUTS) significantly impact men's quality of life and can cause bothersome symptoms, which often interfere with daily functioning and contribute to psychological distress. While pharmacological and surgical treatments are effective, they can have side effects, and not all men require or desire these interventions. The aim of this study is to assess the impact of self-management interventions on symptom severity.

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Background: Anterior segment ischaemia (ASI) is a rare but feared complication associated with strabismus surgery, arising from damage of the anterior ciliary arteries that run along the extraocular rectus muscles. It has been reported that the risk of ASI following strabismus surgery increases when the vertical rectus muscles are involved. The aim of the present study was to monitor anterior segment perfusion in real time during inferior rectus muscle surgery.

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Purpose: There is a need for a simple, non-invasive, and easily accessible 3D imaging technique for the anophthalmic socket to create imaging data for future 3D printing of prostheses. This study aimed to investigate the feasibility of using a novel handheld tomographic ultrasound for 3D mapping of the anophthalmic socket.

Methods: Ten anophthalmic sockets were scanned using a tomographic ultrasound system and the results were compared to CT scanned impression molds from the same sockets.

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Background: Temporomandibular disorders (TMD) are a diverse set of musculoskeletal and neuromuscular problems involving the temporomandibular joint complex and surrounding muscles 1. TMD prevalence has varied from one location to the next, with estimates ranging from 6 to 68 % in various types Objectives were to compare the efficacy of NSAIDs with intra-articular injection of corticosteroids in patients suffering from temporomandibular disorders (TMD) due to disc displacement without reduction in terms of mean pain score and mean mouth opening. This Randomized control trial was conducted at the Oral & Maxillofacial Surgery Department, PMC Dental institute, Faisalabad Medical University, Faisalabad, Pakistan, from 6th April 2018 to 6th April 2019.

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To describe the phenotype of a novel form of autosomal dominant episodic nystagmus and to identify the potential genetic aetiology. We identified several individuals in a large Swedish family affected by episodic nystagmus. In total, 39 family members from five generations were invited to participate in the study, of which 17 were included (12 affected and 5 unaffected).

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Background: Telemedicine holds immense potential to revolutionise healthcare delivery, particularly in resource-limited settings and for patients with chronic diseases. Despite proven benefits and policy reforms, the use of telemedicine remains low due to several patient, technology, and system-level barriers. Assisted telemedicine employs trained health professionals to connect patients with physicians, which can improve access and scope of telemedicine.

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Background: Presence of positive biopsy margins in melanoma can provoke anxiety over potential disease progression from delays to surgical excision, but their impact on outcomes is unknown. We aimed to compare the presence of residual melanoma in the surgical excision specimen and survival between patients with negative, microscopically positive, and macroscopically positive biopsy margins.

Methods: Patients with cutaneous melanoma who underwent surgical excision over a 13-year period were included.

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Article Synopsis
  • The study investigates how thaw time during cryosurgery for actinic keratosis is influenced by local anesthetics, specifically the presence of adrenaline.
  • Twelve patients were monitored using IR thermography to assess temperature changes during the procedure with and without adrenaline.
  • Results showed that using anesthetics with adrenaline led to a longer thaw time, suggesting different freezing times may be necessary for effective treatment, warranting further research for clinical recommendations.
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  • Moderate physical activity (MPA) combined with conventional physical therapy (CPT) significantly improves pain, range of motion, and disability in patients suffering from diabetic adhesive capsulitis compared to those receiving only CPT.
  • A randomized control trial involving 44 patients showed that those who engaged in MPA exhibited larger improvements in their disability scores, as well as pain and mobility measures, within six weeks of treatment.
  • The findings suggest that incorporating MPA into standard treatments for diabetic adhesive capsulitis could enhance patient outcomes and overall quality of life.
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  • - Axial spondyloarthritis, or ankylosing spondylitis, is a chronic inflammatory condition primarily affecting the spine but can also involve peripheral joints, and it is one of several disorders classified as spondyloarthropathies.
  • - The condition is linked to specific genetic markers, particularly the HLA-B27 gene, and involves various inflammatory factors like tumor necrosis factor (TNF), along with the influence of non-HLA genes.
  • - Recent studies suggest that gut microbiota and dysbiosis may contribute to the development of axial spondyloarthritis, highlighting the potential for future research into gut health in the context of this disease.
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Herbs have been used as medicines since antiquity, and it has been discovered that the human body responds well to herbal remedies. Research on the effect of butin was conducted in the current study in the alloxan-induced diabetic rat paradigm. A total of 30 Wistar rats were randomly assigned into the following groups (n = 6): I-Normal; II-Alloxan-induced (50 mg/kg); III-Alloxan + butin 25 mg/kg; IV-Alloxan + butin 50 mg/kg; V-Butin per se 50 mg/kg.

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Background/aims: It is unclear whether a reduction in tear secretion contributes to the discomfort experienced by those with prosthetic eyes. Tear secretion has hitherto only been measured with the Schirmer test which may be affected by the pooling of tears behind the prosthesis. In this study, direct imaging of the lacrimal gland has been performed to measure tear secretion in anophthalmic sockets.

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  • Researchers created bioresorbable lithiated nanoparticles (LiCP) around 20 nm in size for improving bone repair and regeneration.
  • These nanoparticles were shown to be safe for stem cells at high concentrations and significantly boosted key markers for bone and blood vessel formation.
  • In animal tests, LiCP led to better bone formation compared to both a control group and non-lithiated nanoparticles, highlighting their potential for future medical treatments in bone and vascular tissue engineering.
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Cardiovascular diseases (CVD) cause significant global morbidity, mortality and public health burden annually. CVD alters richness, diversity, and composition of Gut microbiota along with RAS and histopathological differences. Present study explores Metformin role in mitigating doxorubicin induced cardiovascular toxicity/remodeling.

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Background: Clinical endocrinology has observed emerging endocrine complications following COVID-19 vaccination, amidst successful reductions in COVID-19 hospitalizations and deaths. The Pfizer-BioNTech and Moderna mRNA vaccines have demonstrated efficacy. Reports indicate a potential association between SARS-CoV-2 vaccination and diabetes, exploring interactions with ACE-2 receptors and molecular mimicry.

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Background: Gliomas are the most frequent, heterogeneous group of tumors arising from glial cells, characterized by difficult monitoring, poor prognosis, and fatality. Tissue biopsy is an established procedure for tumor cell sampling that aids diagnosis, tumor grading, and prediction of prognosis.

Materials And Methods: We studied and compared the levels of liquid biopsy markers in patients with different grades of glioma.

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Background: Methamphetamine (MA) is well recognized as a psychostimulant that can cause neurotoxicity and neurodegeneration, which is associated with cognitive decline, has been confirmed experimentally.

Objective: The research aimed to investigate the neuroprotective properties of europinidin (Eu) in rodents affected by methamphetamine (MA)-induced cognitive impairments and hippocampal alterations. This was achieved by inhibiting lipid peroxidation and pro-inflammatory markers.

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BAP1-Tumor Predisposition Syndrome (TPDS) is caused by germline variants in BAP1 and predisposes to solid tumors. After observation of a radiologically malignant-appearing splenic mass with benign pathology in a patient with BAP1-TPDS, we sought to retrospectively characterize splenic lesions in individuals with BAP1-TPDS seen at a comprehensive cancer center. A dedicated radiology review for splenic abnormalities was performed.

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Objective: Malvidin is a natural, biologically active polyphenol found in several fruits. It exhibits several therapeutic benefits; however, limited studies are available on its effects on neurodegenerative clinical conditions, including Parkinson's disease. The study aimed to investigate the therapeutic properties of malvidin on rotenone-triggered Parkinson's disease in an animal model.

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The growing requirement for real-time monitoring of health factors such as heart rate, temperature, and blood glucose levels has resulted in an increase in demand for electrochemical sensors. This study focuses on enzyme-free glucose sensors based on 2D-MoS nanostructures explored by simple hydrothermal route. The 2D-MoS nanostructures were characterized by powder X-ray diffraction, energy-dispersive X-ray spectroscopy, scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, and XPS techniques and were immobilized at GCE to obtain MoS-GCE interface.

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 Conflicting evidence regarding the laparoscopic versus open cholecystectomy outcomes in scientific literature impacts the medical decision-making for patients with gallbladder disease. This study aimed to compare a range of primary and secondary outcomes between patients receiving laparoscopic cholecystectomy and those with open intervention.  Articles published from 1993 to 2023 were explored by utilizing advanced filters of PubMed Central/Medline, Web of Science, CINAHL, JSTOR, Cochrane Library, Scopus, and EBSCO.

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