Publications by authors named "Sheikh Jalal"
Article Synopsis
- On March 22, 2023, the FDA approved rezafungin (Rezzayo) for treating candidemia and invasive candidiasis in adults lacking alternative treatments.
- Rezafungin is an echinocandin that allows for weekly dosing, potentially reducing the need for central venous catheters by enabling outpatient treatment.
- The approval was based on a phase 3 study showing rezafungin's effectiveness compared to other echinocandins, with identified safety concerns from animal studies being consistent with the safety profiles of existing approved drugs.
An elevated hepatic venous pressure gradient (HVPG) has been associated with risk of variceal bleeding, and outcome and survival after variceal bleeding. In this pilot study, we measured HVPG in 40 patients with liver cirrhosis and studied its relationship with etiology of liver disease, esophageal variceal size, history of variceal bleeding or ascites, biochemical liver tests and Child-Pugh class. There was no procedurerelated complication.
View Article and Find Full Text PDFObjective: Published observations about cardiovascular alterations in normotensive individuals genetically predisposed to develop essential hypertension are conflicting. We tested the hypothesis that abnormalities in left ventricular mass and/or functions may be present in normotensive children of hypertensive parents.
Methods: One hundred normotensive offsprings (6 to 18 year age) of hypertensive parents (OHP) and an equal number of age- and sex-matched normotensive offsprings of normotensive parents (ONP) were studied with 2-dimensionally guided M-mode and Doppler echocardiography for left ventricular (LV) dimensions, mass, and systolic and diastolic functions.