Gold nanoparticle conjugated PLGA-PEG-SA-PEG-PLGA multiblock copolymer nanoparticles: synthesis, characterization, in vivo release of rifampicin.

A series of succinate linearly linked PLGA-PEG-SA-PEG-PLGA multiblock copolymers were synthesized using direct melt polycondensation and characterized using inherent viscosity, gel permeation chromatography (GPC), FTIR and H-NMR spectroscopy techniques. Gold nanoparticles (AuNPs) were synthesized using an as-synthesized citrate-PEG (CPEG) hybrid dendron, which acts as a reducing agent as well as a stabilizing agent. The CPEG capped AuNPs were characterized using UV-visible spectroscopy and TEM analysis.

Suppression of atrial natriuretic peptide/natriuretic peptide receptor-A-mediated signaling upregulates angiotensin-II-induced collagen synthesis in adult cardiac fibroblasts.

Cardiac hormone atrial natriuretic peptide (ANP) and its receptor natriuretic peptide receptor-A (NPR-A) system acts as an intrinsic negative regulator of abnormal extracellular matrix (ECM) remodeling in the heart. However, the underlying mechanism by which ANP/NPR-A system opposes the ECM remodeling in the diseased heart is not well understood. Here, we investigated the anti-fibrotic mechanism of ANP/NPR-A in fibrotic agonist Angiotensin- II (ANG II)-treated adult cardiac fibroblast (CF) cells.