Publications by authors named "Shehzad A Huda"
Pathophysiology
June 2019
Article Synopsis
- - The study investigates how metabolic stress (like low glucose and low oxygen) affects the expression of endothelial cell adhesion molecules (ECAMs) during necrotizing enterocolitis (NEC), a serious gut condition in neonates caused by inflammation.
- - Using intestinal microvascular endothelial cells, researchers found that inflammation from the cytokine TNF-α, when combined with conditions of hypoxia and aglycemia, significantly increased the surface expression of several ECAMs, including ICAM-1, VCAM-1, and E-selectin.
- - The findings suggest that changes in energy metabolism can impact inflammatory processes by regulating ECAM mobilization, highlighting a potential mechanism involved in the pathology of NEC.
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