Inflammation and caspase activation in long-term renal ischemia/reperfusion injury and immunosuppression in rats.

Background: We have previously shown the long-term influence of renal ischemia/reperfusion (I/R) injury and immunosuppression on fibrotic genes and apoptosis in a rat model. For the first time, we have now investigated the effects of I/R and immunosuppression on inflammation and caspase activation.

Methods: I/R injury was induced in the right kidney and the left was removed.